Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells

Advances in Enzyme Regulation

Volumn 37, Issue , 1997, Pages 59-76

  Jansen, Gerrit ^a   Mauritz, Robert M ^a   Assaraf, Yehuda G ^b   Sprecher, Hannah ^b   Drori, Stavit ^b   Kathmann, Ietje ^a   Westerhof, G Robbin ^a   Priest, David G ^c   Bunni, Marlene ^c   Pinedo, Herbert M ^a   Schornagel, Jan H ^d   Peters, Godefridus J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; 5-METHYLTETRAHYDROFOLATE; ADENOSINE; CARRIER PROTEIN; DRUG DERIVATIVE; ENZYME INHIBITOR; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLIC ACID DERIVATIVE; FOLINIC ACID; METHOTREXATE; REDUCED FOLATE CARRIER; S ADENOSYLMETHIONINE; TETRAHYDROFOLIC ACID DERIVATIVE; THYMIDYLATE SYNTHASE; TOMUDEX;

CANCER CELL CULTURE; CANCER RESISTANCE; CELL CULTURE; CELL DIVISION; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG RESISTANCE; DRUG TRANSPORT; DRUG UPTAKE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KINETICS; LEUKEMIA CELL; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ADENOSINE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL DIVISION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; LEUCOVORIN; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; S-ADENOSYLMETHIONINE; TETRAHYDROFOLATES; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0030866782     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(96)00012-X     Document Type: Conference Paper

References (39)

1. 1. F. M. SIROTNAK, Obligate genetic expression in tumor cells of a fetal membrane property mediating 'folate' transport: biological significance and implications for improved therapy of human cancer, Cancer Res. 45, 3992-4000 (1985).
2. 2. I. D. GOLDMAN and L. H. MATHERLY, The cellular pharmacology of Methotrexate, Pharmac. Ther. 28, 77-102 (1985).
3. 3. L. H. MATHERLY, Mechanisms of receptor-mediated folate and antifolate membrane transport in cancer chemotherapy, pp. 453-524 in Drug Transport in Antimicrobial and Anticancer Chemotherapy (N. H. GEORGOPAPADAKOU, ed.). Marcel Dekker, NY (1995).
4. 4. G. J. PETERS and S. P. ACKLAND, New antimetabolites in preclinical and clinical development, Exp. Opin. Invest. Drugs 5, 637-679 (1996).
5. 5. G. B. HENDERSON, J. M. TSJUI and H. P. KUMAR, Characterization of the individual transport routes that mediate the influx and efflux of Methotrexate in CCRF-CEM human lymphoblastic cells, Cancer Res. 46, 1633-1638 (1986).
6. 6. G. R. WESTERHOF, J. H. SCHORNAGEL, I. KATHMANN, A. L. JACKMAN, A. ROSOWSKY, R. A. FORSCH, J. B. HYNES, F. T. BOYLE, G. J. PETERS, H. M. PINEDO and G. JANSEN, Carrier-and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular structure and biological activity, Mol. Pharmacol. 48, 459-471 (1995).
7. 7. F. M. HUENNEKENS, T. H. DUFFY and K. S. VITOLS, Folic acid metabolism and its disruption by pharmacologic agents, NCI Monographs 5, 1-8 (1987).
8. 8. I. D. GOLDMAN, A model system for the study of heteroexchange diffusion: Methotrexatefolate interactions in L1210 and Ehrlich ascites tumor cells, Biochim. Biophys. Acta 233, 624-633 (1971).
9. 9. G. J. PETERS and G. JANSEN, Resistance to antimetabolites, pp. 543-585 in Principles of Antineoplastic Drug Development and Pharmacology (R. L. SCHILSKY, G. A. MILANO and M. J. RATAIN, eds.). Marcel Dekker, NY (1996).
10. 10. A. L. JACKMAN and A. H. CALVERT, Folate-based thymidylate synthase inhibitors as anticancer drugs, Ann. Oncol. 6, 871-881 (1995).
11. 11. J. R. BERTINO, Ode to Methotrexate, J. Clin. Oncol. 11, 5-14 (1993).
12. 12. K. H. DIXON, B. C. LANPHER, J. CHIU, K. KELLEY and K. H. COWAN, A novel cDNA restores reduced folate carrier activity and Methotrexate sensitivity to transport deficient cells, J. Biol. Chem. 269, 17-20 (1994).
13. 13. F. M. R. WILLIAMS, R. C. MURRAY, T. M. UNDERHILL and W. F. FLINTOFF, Isolation of a hamster cDNA clone encoding for a function involved in Methotrexate uptake, J. Biol. Chem. 269, 5810-5816 (1994).
14. 14. P. D. PRASAD, S. RAMAMOORTHY, F. H. LEIBACH and V. GANAPATHY, Molecular cloning of the human placental folate receptor, Biochem. Biophys. Res. Commun. 206, 681-687 (1995).
15. 15. F. M. R. WILLIAMS and W. F. FLINTOFF, Isolation of a human cDNA that complements a mutant hamster cell defective in Methotrexate uptake, J. Biol. Chem. 270, 2987-2992 (1995).
16. 16. S. C. WONG, S. A. PROEFKE, A. BUSHAN and L. H. MATHERLY, Isolation of human cDNAs that restore Methotrexate sensitivity and reduced folate carrier activity in Methotrexate transport-defective Chinese hamster ovary cells, J. Biol. Chem. 270, 17468-17475 (1995).
17. 17. J. A. MOSCOW, M. GONG, R. HE, M. K. SGAGIAS, K. H. DIXON, S. L. ANZICK, P. S. MELTZER and K. H. COWAN, Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, Methotrexate-resistant human breast cancer cells, Cancer Res. 55, 3790-3794 (1995).
18. 18. K. E. BRIGLE, M. J. SPINELLA, E. E. SIERRA and I. D. GOLDMAN, Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line, J. Biol. Chem. 270, 22974-22979 (1995).
19. 19. L. H. MATHERLY, C. A. CZAJKOWSKI and S. M. ANGELES, Identification of a highly glycosylated Methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and Methotrexate transport, Cancer Res. 51, 3420-3426 (1991).
20. 20. J. H. FREISHEIM, M. RATNAM, T. P. MCALINDEN, K. M. R. PRASAD, F. E. WILLIAMS, G. R. WESTERHOF, J. H. SCHORNAGEL and G. JANSEN, Molecular events in the membrane transport of Methotrexate in human CCRF-CEM leukemia cell lines, Advan. Enzyme Regul. 32, 17-31 (1992).
21. 21. G. JANSEN, G. R. WESTERHOF, M. J. A. JARMUSZEWSKI, I. KATHMANN, G. RIJKSEN and J. H. SCHORNAGEL, Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier, J. Biol. Chem. 265, 18272-18277 (1990).
22. 22. A. ROSOWSKY, H. LAZARUS, G. C. YUAN, W. R. BELTZ, L. MANGINI, H. T. ABELSON, E. J. MODEST and E. FREI III, Effects of Methotrexate esters and other lipophylic antifolates on Methotrexate-resistant human leukemic lymphoblasts, Biochem. Pharmacol. 29, 648-652 (1980).
23. 23. L. H. MATHERLY, S. M. ANGELES and J. J. MCGUIRE, Determinants of disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and Methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport, Biochem. Pharmacol. 46, 2185-2195 (1993).
24. 24. J. C. YALOWICH and T. I. KALMAN, Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro, Biochem. Pharmacol. 34, 2319-2324 (1985).
25. 25. D. G. PRIEST, J. C. SCHMITZ, M. A. BUNNI and R. K. STUART, Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously, J. Natl. Cancer Inst. 83, 1806-1812 (1991).
26. 26. M. A. BUNNI, F. M. SIROTNAK, G. M. OTTER and D. G. PRIEST, Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of Methotrexate-pretreated mice, Cancer Chemother. Pharmacol. 34, 455-458 (1994).
27. 27. M. G. COLLIS and S. M. O. HOURANI, Adenosine receptor subtypes, Trends Pharm. Sci. 4, 360-366 (1993).
28. 28. J. BARANKIEWICZ and A. COHEN, Evidence for distinct catabolic pathways of adenine ribonucleotides and deoxyribonucleotides in human T lymphoblastoid cells, J. Biol. Chem. 259, 15178-15181 (1984).
29. 29. R. T. BORCHARDT, S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents, J. Med Chem. 223, 347-356 (1980).
30. 30. P. M. UELAND, Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase, Pharmacol. Rev. 34, 223-253 (1982).
31. 31. S. J. JAMES, B. J. MILLER, L. J. MCGARRITY and S. M. MORRIS, The effect of folic and/or methionine deficiency on deoxyribonucleotide pools and cell cycle distribution in mitogen-stimulated rat lymphocytes, Cell Prolif. 27, 395-406 (1994).
32. 32. I. P. POGRIBNY, A. G. BASNAKIAN, B. J. MILLER, N. G. LOPATINA, L. A. POIRIER and S. J. JAMES, Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats, Cancer Res. 55, 1894-1901 (1995).
33. 33. A. BIRD, The essentials of DNA methylation, Cell 70, 5-8 (1992).
34. 34. P. A. JONES, DNA methylation errors and cancer, Cancer Res. 56, 2463-2467 (1996).
35. 35. H. SPRECHER, G. JANSEN, S. DRORI, J. H. SCHORNAGEL, G. J. PETERS and Y. G. ASSARAF, Reduced folate carrier (RFC) gene amplification and overexpression of altered transcripts in human leukemia CEM-7A cells, Proc. Am. Assoc. Cancer Res. 37, 381 (1996).
36. 36. A. L. JACKMAN, G. A. TAYLOR, W. GIBSON, R. KIMBELL, M. BROWN, H. A. CALVERT, I. R. JUDSON and L. R. HUGHES, ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical studies, Cancer Res. 51, 5579-5586 (1991).
37. 37. D. S. DUCH, S. BANKS, I. K. DEV, S. H. DICKERSON, R. FERONE, L. S. HEATH, J. HUMPHREYS, V. KNICK, W. PENDERGAST, S. SINGER, G. K. SMITH, K. WATERS and H. R. WILSON, Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase, Cancer Res. 53, 810-818 (1993).
38. 38. M. H. HANLON and R. FERONE, In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase, Cancer Res. 56, 3301-3306 (1996).
39. 39. L. CHEN, H. QI, J. KORENBERG, T. A. GARROW, Y. J. CHOI and B. SHANE, Purification and properties of human cytosolic folylpoly-γ-glutamate synthetase and organization, localization, and differential splicing of its gene, J. Biol. Chem. 271, 13077-13087 (1996).