메뉴 건너뛰기




Volumn 39, Issue 4, 1997, Pages 163-174

Mitoxantrone in the treatment of acute myelogenous leukemia: A review

Author keywords

Acute myelogenous leukemia; Chemotherapy; Intercalating agents; Mitoxantrone

Indexed keywords

CYTARABINE; DAUNORUBICIN; ETOPOSIDE; IDARUBICIN; MITOXANTRONE;

EID: 0030866571     PISSN: 12693286     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00282-997-0163-8     Document Type: Review
Times cited : (42)

References (102)
  • 1
    • 0021822511 scopus 로고
    • Pharmacology of mitoxantrone: Mode of action and pharmacokinetics
    • Alberts DS, Peng YM, Bowden GT (1985) Pharmacology of mitoxantrone: Mode of action and pharmacokinetics. Invest New Drugs 3: 101-108
    • (1985) Invest New Drugs , vol.3 , pp. 101-108
    • Alberts, D.S.1    Peng, Y.M.2    Bowden, G.T.3
  • 2
    • 0025760557 scopus 로고
    • Mitoxantrone, etoposide and intermediate-dose cytarabine: An effective and tolerable regimen for the treatment of refractory acute myeloid leukemia
    • Amadori S, Arcese W, Isacchi G, et al. (1991) Mitoxantrone, etoposide and intermediate-dose cytarabine: an effective and tolerable regimen for the treatment of refractory acute myeloid leukemia. J Clin Oncol 9: 1210-1214
    • (1991) J Clin Oncol , vol.9 , pp. 1210-1214
    • Amadori, S.1    Arcese, W.2    Isacchi, G.3
  • 3
    • 0025182187 scopus 로고
    • Treatment of relapsed and refractory acute myeloid leukemia with diaziquone and mitoxantrone: A CALGB phase I study
    • Amrein PC, Davis RB, Mayer RJ, et al. (1990) Treatment of relapsed and refractory acute myeloid leukemia with diaziquone and mitoxantrone: A CALGB phase I study. Am J Hematol 35: 80-83
    • (1990) Am J Hematol , vol.35 , pp. 80-83
    • Amrein, P.C.1    Davis, R.B.2    Mayer, R.J.3
  • 4
    • 0020539187 scopus 로고
    • Phase I trial of mitoxantrone by 24-hour continuous infusion
    • Anderson KC, Garnick MB, Meshad MW, et al. (1983) Phase I trial of mitoxantrone by 24-hour continuous infusion. Cancer Treat Rep 67: 435-438
    • (1983) Cancer Treat Rep , vol.67 , pp. 435-438
    • Anderson, K.C.1    Garnick, M.B.2    Meshad, M.W.3
  • 5
    • 0025814591 scopus 로고
    • Intensive sequential chemotherapy with mitoxantrone and continuous infusion etoposide and cytarabine for resistant or relapsing acute myelogenous leukemia
    • Archimbaud E, Leblond V, Michallet M, et al. (1991) Intensive sequential chemotherapy with mitoxantrone and continuous infusion etoposide and cytarabine for resistant or relapsing acute myelogenous leukemia. Blood 77: 1894-1900
    • (1991) Blood , vol.77 , pp. 1894-1900
    • Archimbaud, E.1    Leblond, V.2    Michallet, M.3
  • 6
    • 0028801482 scopus 로고
    • Timed sequential chemotherapy for previously treated patients with acute myeloid leukemia: Long-term follow-up of the etoposide, mitoxantrone, and cytarabine- 86 trial
    • Archimbaud E, Thomas X, Leblond V, et al. (1995) Timed sequential chemotherapy for previously treated patients with acute myeloid leukemia: long-term follow-up of the etoposide, mitoxantrone, and cytarabine- 86 trial. J Clin Oncol 13: 11-18
    • (1995) J Clin Oncol , vol.13 , pp. 11-18
    • Archimbaud, E.1    Thomas, X.2    Leblond, V.3
  • 7
    • 13344270921 scopus 로고    scopus 로고
    • Timed sequential chemotherapy for advanced acute myeloid leukemia
    • Archimbaud E, Leblond V, Fenaux P, et al. (1996) Timed sequential chemotherapy for advanced acute myeloid leukemia. Hematol Cell Ther 38: 161-167
    • (1996) Hematol Cell Ther , vol.38 , pp. 161-167
    • Archimbaud, E.1    Leblond, V.2    Fenaux, P.3
  • 8
    • 0010621629 scopus 로고    scopus 로고
    • A randomized comparison of idarubicin vs mitoxantrone, in association to VP-16 and cytarabine for induction/consolidation therapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia (AML)
    • Archimbaud E, Jehn U, Thomas X, et al. (1996) A randomized comparison of idarubicin vs mitoxantrone, in association to VP-16 and cytarabine for induction/consolidation therapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia (AML). Br J Haematol 93 [Suppl 2]: 133-134
    • (1996) Br J Haematol , vol.93 , Issue.2 SUPPL. , pp. 133-134
    • Archimbaud, E.1    Jehn, U.2    Thomas, X.3
  • 9
    • 0022003318 scopus 로고
    • Phase I-II of mitoxantrone in acute leukemia
    • Arlin ZA, Silver R, Cassileth P, et al. (1985) Phase I-II of mitoxantrone in acute leukemia. Cancer Treat Rep 69: 61-64
    • (1985) Cancer Treat Rep , vol.69 , pp. 61-64
    • Arlin, Z.A.1    Silver, R.2    Cassileth, P.3
  • 10
    • 0025275742 scopus 로고
    • Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL)
    • Arlin Z, Case DC, Moore J, et al. (1990) Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL). Leukemia 4: 177-183
    • (1990) Leukemia , vol.4 , pp. 177-183
    • Arlin, Z.1    Case, D.C.2    Moore, J.3
  • 11
    • 0028966166 scopus 로고
    • Rationale for the use of mitoxantrone in the older patient: Cardiac toxicity
    • Benjamin RS (1995) Rationale for the use of mitoxantrone in the older patient: cardiac toxicity. Semin Oncol 22 [Suppl 1]: 11-13
    • (1995) Semin Oncol , vol.22 , Issue.1 SUPPL. , pp. 11-13
    • Benjamin, R.S.1
  • 12
    • 0025376417 scopus 로고
    • Mitoxantrone for refractory and relapsed acute leukemia
    • Bezwoda WR, Bernasconi C, Hutchinson RM, et al. (1990) Mitoxantrone for refractory and relapsed acute leukemia. Cancer: 418-422
    • (1990) Cancer , pp. 418-422
    • Bezwoda, W.R.1    Bernasconi, C.2    Hutchinson, R.M.3
  • 13
    • 11944275668 scopus 로고
    • Etoposide in acute nonlymphocytic leukemia
    • Bishop JF, Lowenthal LM, Joshua D, et al. (1990) Etoposide in acute nonlymphocytic leukemia. Blood 75: 27-32
    • (1990) Blood , vol.75 , pp. 27-32
    • Bishop, J.F.1    Lowenthal, L.M.2    Joshua, D.3
  • 14
    • 9044228414 scopus 로고    scopus 로고
    • A randomized study of high-dose cytarabine induction in acute myeloid leukemia
    • Bishop JF, Matthews JP, Young GA, et al. (1996) A randomized study of high-dose cytarabine induction in acute myeloid leukemia. Blood 87: 1710-1717
    • (1996) Blood , vol.87 , pp. 1710-1717
    • Bishop, J.F.1    Matthews, J.P.2    Young, G.A.3
  • 15
    • 0025008597 scopus 로고
    • Mitoxantrone, etoposide and cytarabine in the treatment of acute nonlymphocytic leukemia
    • Björkholm M, Björnsdottir J, Stenke L, et al. (1990) Mitoxantrone, etoposide and cytarabine in the treatment of acute nonlymphocytic leukemia. Oncology 47: 112-114
    • (1990) Oncology , vol.47 , pp. 112-114
    • Björkholm, M.1    Björnsdottir, J.2    Stenke, L.3
  • 16
    • 0029036960 scopus 로고
    • Mitoxantrone, etoposide and ara-C versus doxorubicin-DNA, ara-C, thioguanine, vincristine and prednisolone in the treatment of patients with acute myelocytic leukemia. A randomized comparison
    • Bjorkholm M, Liliemark J, Gahrton G, et al. (1995) Mitoxantrone, etoposide and ara-C versus doxorubicin-DNA, ara-C, thioguanine, vincristine and prednisolone in the treatment of patients with acute myelocytic leukemia. A randomized comparison. Eur J Haematol 55: 19-23
    • (1995) Eur J Haematol , vol.55 , pp. 19-23
    • Bjorkholm, M.1    Liliemark, J.2    Gahrton, G.3
  • 17
    • 0029966676 scopus 로고    scopus 로고
    • Therapy of untreated acute myeloid leukemia in the elderly: Remission-induction using a non-cytarabine-containing regimen of mitoxantrone plus etoposide
    • Bow EJ, Sutherland JA, Kilpatrick MG, et al. (1996) Therapy of untreated acute myeloid leukemia in the elderly: remission-induction using a non-cytarabine-containing regimen of mitoxantrone plus etoposide. J Clin Oncol 14: 1345-1352
    • (1996) J Clin Oncol , vol.14 , pp. 1345-1352
    • Bow, E.J.1    Sutherland, J.A.2    Kilpatrick, M.G.3
  • 18
    • 0023260839 scopus 로고
    • Treatment of acute myeloid leukemia with intermediate-dose cytosine arabinoside and mitoxantrone
    • Brito-Babapulle F, Catovsky D, Newland AC, et al. (1987) Treatment of acute myeloid leukemia with intermediate-dose cytosine arabinoside and mitoxantrone. Semin Oncol 14 [Suppl 1]: 51-52
    • (1987) Semin Oncol , vol.14 , Issue.1 SUPPL. , pp. 51-52
    • Brito-Babapulle, F.1    Catovsky, D.2    Newland, A.C.3
  • 19
    • 0001593390 scopus 로고    scopus 로고
    • Allo and auto BMT reduce relapse risk in AML in CR1 but do not significantly improve overall survival: Results of the MRC AML10 trial
    • Burnett AK, Goldstone AH, Stevens R, et al. (1996) Allo and auto BMT reduce relapse risk in AML in CR1 but do not significantly improve overall survival: results of the MRC AML10 trial. Br J Haematol 93 [Suppl 2]: 313a
    • (1996) Br J Haematol , vol.93 , Issue.2 SUPPL.
    • Burnett, A.K.1    Goldstone, A.H.2    Stevens, R.3
  • 20
    • 0016599208 scopus 로고
    • Comparative study of cytosine arabinoside therapy alone and combined with thioguanine, mercaptopurine or daunorubicin in acute myelocytic leukemia
    • Carey RW, Ribas-Mundo M, Ellison RR, et al. (1975) Comparative study of cytosine arabinoside therapy alone and combined with thioguanine, mercaptopurine or daunorubicin in acute myelocytic leukemia. Cancer 36: 1560-1566
    • (1975) Cancer , vol.36 , pp. 1560-1566
    • Carey, R.W.1    Ribas-Mundo, M.2    Ellison, R.R.3
  • 21
    • 0004682129 scopus 로고    scopus 로고
    • Sequential induction or double induction chemotherapy increase didease free survival compared to "3 + 7" chemotherapy in less than 50 years adults with acute myeloid leukemia (AML)
    • Castaigne S, Archimbaud E, Bordessoule D, et al. (1996) Sequential induction or double induction chemotherapy increase didease free survival compared to "3 + 7" chemotherapy in less than 50 years adults with acute myeloid leukemia (AML). Blood 88 [Suppl 1]: 291a
    • (1996) Blood , vol.88 , Issue.1 SUPPL.
    • Castaigne, S.1    Archimbaud, E.2    Bordessoule, D.3
  • 22
    • 0023111893 scopus 로고
    • Cross-resistance of menogaril and mitoxantrone in a subline of P388 leukemia resistant to doxorubicin
    • Chandrasekaran B, Dimling J, Capizzi RL (1987) Cross-resistance of menogaril and mitoxantrone in a subline of P388 leukemia resistant to doxorubicin. Cancer Treat Rep 71: 195-196
    • (1987) Cancer Treat Rep , vol.71 , pp. 195-196
    • Chandrasekaran, B.1    Dimling, J.2    Capizzi, R.L.3
  • 24
    • 0021744523 scopus 로고
    • Clinical safety and tolerance of mitoxantrone
    • Crossley RJ (1984) Clinical safety and tolerance of mitoxantrone. Semin Oncol 11 [Suppl 1]: 54-58
    • (1984) Semin Oncol , vol.11 , Issue.1 SUPPL. , pp. 54-58
    • Crossley, R.J.1
  • 25
    • 0028009840 scopus 로고
    • Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine
    • Daenen S, Löwenberg B, Sonneveld P, et al. (1994) Efficacy of etoposide and mitoxantrone in patients with acute myelogenous leukemia refractory to standard induction therapy and intermediate-dose cytarabine with amsidine. Leukemia 8: 6-10
    • (1994) Leukemia , vol.8 , pp. 6-10
    • Daenen, S.1    Löwenberg, B.2    Sonneveld, P.3
  • 26
    • 0008708573 scopus 로고
    • Biochemical pharmacology and tumor bioiogy of mitoxantrone and ametantrone
    • Lown JW (ed) Elsevier, Amsterdam
    • Durr FE (1988) Biochemical pharmacology and tumor bioiogy of mitoxantrone and ametantrone. In: Lown JW (ed) Anthracycline and anthracenedione-based anticancer agents. Elsevier, Amsterdam, pp. 163-171
    • (1988) Anthracycline and Anthracenedione-based Anticancer Agents , pp. 163-171
    • Durr, F.E.1
  • 27
    • 4243320788 scopus 로고
    • Mitoxantrone (mitox) and cytosine arabinoside (ara-C) in acute nonlymphocytic leukemia (ANLL) and blast crisis of chronic myelogenous leukemia (CML-B)
    • Dutcher JP, Wiernik PH, Strauman JJ, et al. (1985) Mitoxantrone (mitox) and cytosine arabinoside (ara-C) in acute nonlymphocytic leukemia (ANLL) and blast crisis of chronic myelogenous leukemia (CML-B). Proc Am Soc Clin Oncol 4: 170a
    • (1985) Proc Am Soc Clin Oncol , vol.4
    • Dutcher, J.P.1    Wiernik, P.H.2    Strauman, J.J.3
  • 28
  • 29
    • 0025061187 scopus 로고
    • Combination of mitoxantrone and etoposide in patients aged over 60 years with untreated acute myelogenous leukemia
    • Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Springer, Berlin Heidelberg New York
    • Ehninger G, Fackler-Schwalbe E, Freund M, et al. (1990) Combination of mitoxantrone and etoposide in patients aged over 60 years with untreated acute myelogenous leukemia. In: Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Haematology and blood transfusion. Acute leukemias II, prognostic factors and treatment strategies, vol. 33. Springer, Berlin Heidelberg New York, pp. 316-317
    • (1990) Haematology and Blood Transfusion. Acute Leukemias II, Prognostic Factors and Treatment Strategies , vol.33 , pp. 316-317
    • Ehninger, G.1    Fackler-Schwalbe, E.2    Freund, M.3
  • 30
    • 0019409273 scopus 로고
    • Phase I-II study of dihydroxyanthracenedione (DHAD) in acute leukemia (AL)
    • Estey EH, Keating MJ, McCreadie KB, et al. (1981) Phase I-II study of dihydroxyanthracenedione (DHAD) in acute leukemia (AL). Proc Am Soc Cancer Res 22: 490a
    • (1981) Proc Am Soc Cancer Res , vol.22
    • Estey, E.H.1    Keating, M.J.2    McCreadie, K.B.3
  • 31
    • 0020591410 scopus 로고
    • Phase II trial of mitoxantrone in refractory acute leukemia
    • Estey EH, Keating MJ, McCredie KB, et al. (1983) Phase II trial of mitoxantrone in refractory acute leukemia. Cancer Treat Rep 67: 389-390
    • (1983) Cancer Treat Rep , vol.67 , pp. 389-390
    • Estey, E.H.1    Keating, M.J.2    McCredie, K.B.3
  • 32
    • 0027429618 scopus 로고
    • Phase II clinical and pharmacokinetic evaluation of high-dose mitoxantrone in combination with cytarabine in patients with acute leukemia
    • Feldman EJ, Alberts DS, Arlin Z, et al. (1993) Phase II clinical and pharmacokinetic evaluation of high-dose mitoxantrone in combination with cytarabine in patients with acute leukemia. J Clin Oncol 11: 2002-2009
    • (1993) J Clin Oncol , vol.11 , pp. 2002-2009
    • Feldman, E.J.1    Alberts, D.S.2    Arlin, Z.3
  • 33
    • 9844220564 scopus 로고
    • Intensive induction without consolidation in elderly patients with newly diagnosed acute myeloid leukemia (AML)
    • Feldman E, Seiter K, Linker C, et al. (1995) Intensive induction without consolidation in elderly patients with newly diagnosed acute myeloid leukemia (AML). Proc Am Soc Clin Oncol 14: 335a
    • (1995) Proc Am Soc Clin Oncol , vol.14
    • Feldman, E.1    Seiter, K.2    Linker, C.3
  • 34
    • 0019966392 scopus 로고
    • Antitumor activity of mitoxantrone against murine experimental tumors: Comparative analysis against various antitumor antibiotics
    • Fujimoto S, Ogawa M (1982) Antitumor activity of mitoxantrone against murine experimental tumors: Comparative analysis against various antitumor antibiotics. Cancer Chemoter Pharmacol 8: 157-161
    • (1982) Cancer Chemoter Pharmacol , vol.8 , pp. 157-161
    • Fujimoto, S.1    Ogawa, M.2
  • 35
    • 0027209493 scopus 로고
    • Mitoxantrone and 5-azacytidine for refractory/relapsed ANLL or CML in blast crisis: A leukemia mtergroup study
    • Goldberg J, Gryn J, Raza A, et al. (1993) Mitoxantrone and 5-azacytidine for refractory/relapsed ANLL or CML in blast crisis: a leukemia mtergroup study. Am J Hematol 43: 286-290
    • (1993) Am J Hematol , vol.43 , pp. 286-290
    • Goldberg, J.1    Gryn, J.2    Raza, A.3
  • 36
    • 0024381264 scopus 로고
    • A phase I pharmacokinetic study of 21-day continuous infusion mitoxantrone
    • Greidanus J, De Vries EGE, Mulder NH, et al. (1989) A phase I pharmacokinetic study of 21-day continuous infusion mitoxantrone. J Clin Oncol 7: 790-797
    • (1989) J Clin Oncol , vol.7 , pp. 790-797
    • Greidanus, J.1    De Vries, E.G.E.2    Mulder, N.H.3
  • 37
    • 0027738496 scopus 로고
    • Idarubicin/cytosine arabinoside and mitoxantrone/etoposide for the treatment of de novo acute myelogenous leukemia
    • Haas R, Ho AD, Del Valle F, et al. (1993) Idarubicin/cytosine arabinoside and mitoxantrone/etoposide for the treatment of de novo acute myelogenous leukemia. Semin Oncol 20: 20-26
    • (1993) Semin Oncol , vol.20 , pp. 20-26
    • Haas, R.1    Ho, A.D.2    Del Valle, F.3
  • 38
    • 0025201383 scopus 로고
    • Mitoxantrone and intermediate-dose cytarabine in relapsed or refractory acute myeloblastic leukemia
    • Harousseau JL, Milpied N, Brière J, et al. (1990) Mitoxantrone and intermediate-dose cytarabine in relapsed or refractory acute myeloblastic leukemia. Nouv Rev Fr Hematol 32: 227-230
    • (1990) Nouv Rev Fr Hematol , vol.32 , pp. 227-230
    • Harousseau, J.L.1    Milpied, N.2    Brière, J.3
  • 39
    • 0020135302 scopus 로고
    • Safety assessment of a new anticancer compound, mitoxantrone, in Beagie dogs; comparison with doxorubicin. I. Clinical observations
    • Henderson BM, Dougherty WJ, James VC, et al. (1982) Safety assessment of a new anticancer compound, mitoxantrone, in Beagie dogs; comparison with doxorubicin. I. Clinical observations. Cancer Treat Rep 66: 1139-1143
    • (1982) Cancer Treat Rep , vol.66 , pp. 1139-1143
    • Henderson, B.M.1    Dougherty, W.J.2    James, V.C.3
  • 40
    • 0023084099 scopus 로고
    • Phase I/II trial of high-dose cytosine arabinoside and mitoxantrone in adult refractory acute myeloid leukemia
    • Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Springer, Berlin Heidelberg New York
    • Hiddemann W, Kreutzmann H, Straif K, et al. (1987) Phase I/II trial of high-dose cytosine arabinoside and mitoxantrone in adult refractory acute myeloid leukemia. In: Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Haematology and blood transfusion. Acute leukemias II, prognostic factors and treatment strategies, vol. 30. Springer, Berlin Heidelberg New York, pp. 336-338
    • (1987) Haematology and Blood Transfusion. Acute Leukemias II, Prognostic Factors and Treatment Strategies , vol.30 , pp. 336-338
    • Hiddemann, W.1    Kreutzmann, H.2    Straif, K.3
  • 41
    • 0025848167 scopus 로고
    • High-dose versus intermediate-dose cytarabine combined with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia: Results of an age adjusted randomized comparison
    • Hiddemann W, Aul C, Maschmeyer G, et al. (1991) High-dose versus intermediate-dose cytarabine combined with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia: results of an age adjusted randomized comparison. Semin Hematol 28: 35-38
    • (1991) Semin Hematol , vol.28 , pp. 35-38
    • Hiddemann, W.1    Aul, C.2    Maschmeyer, G.3
  • 42
    • 0027416828 scopus 로고
    • High-dose versus intermediate dose cytosine arabinoside combined with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia: Results of an age adjusted randomized comparison
    • Hiddemann W, Aul C, Maschmeyer G, et al. (1993) High-dose versus intermediate dose cytosine arabinoside combined with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia: results of an age adjusted randomized comparison. Leuk Lymphoma 10: 133-137
    • (1993) Leuk Lymphoma , vol.10 , pp. 133-137
    • Hiddemann, W.1    Aul, C.2    Maschmeyer, G.3
  • 43
    • 0023873515 scopus 로고
    • Combination of mitoxantrone and etoposide in refractory acute myelogenous leukemia. An active and well-tolerated regimen
    • Ho AD, Lipp T, Ehninger G, et al. (1988) Combination of mitoxantrone and etoposide in refractory acute myelogenous leukemia. An active and well-tolerated regimen. J Clin Oncol 6: 213-217
    • (1988) J Clin Oncol , vol.6 , pp. 213-217
    • Ho, A.D.1    Lipp, T.2    Ehninger, G.3
  • 44
    • 9844254756 scopus 로고    scopus 로고
    • Treatment of acute myelogenous leukemia (AML) in adult patients: A global approach improves the feasibility of bone marrow transplantation (BMT) as well as long term results
    • Isnard F, Laporte JPh, Chéron N, et al. (1996) Treatment of acute myelogenous leukemia (AML) in adult patients: a global approach improves the feasibility of bone marrow transplantation (BMT) as well as long term results. Br J Haematol 93 [Suppl 2]: 222a
    • (1996) Br J Haematol , vol.93 , Issue.2 SUPPL.
    • Isnard, F.1    Laporte, J.Ph.2    Chéron, N.3
  • 45
    • 84884526393 scopus 로고
    • Preclinical toxicology studies on mitoxantrone and bisantrene
    • Rozencweig M, et al. (eds) Raven, New York
    • James V, Chicarelli F, Dougherty W, et al. (1983) Preclinical toxicology studies on mitoxantrone and bisantrene. In: Rozencweig M, et al. (eds) New anticancer drugs: mitoxantrone and bisantrene. Raven, New York, pp. 47-69
    • (1983) New Anticancer Drugs: Mitoxantrone and Bisantrene , pp. 47-69
    • James, V.1    Chicarelli, F.2    Dougherty, W.3
  • 46
    • 0026631431 scopus 로고
    • Effects of mitoxantrone in combination with other anticancer agents on a human leukemia cell line
    • Kano Y, Suzuki K, Akutsu M, et al. (1992) Effects of mitoxantrone in combination with other anticancer agents on a human leukemia cell line. Leukemia 6: 440-445
    • (1992) Leukemia , vol.6 , pp. 440-445
    • Kano, Y.1    Suzuki, K.2    Akutsu, M.3
  • 47
    • 0028566695 scopus 로고
    • Mitoxantrone and standard dose cytosine arabinoside therapy in refractory or relapsed acute leukemia
    • Keskin A, Tombuloglu M, Atamer MA, et al. (1994) Mitoxantrone and standard dose cytosine arabinoside therapy in refractory or relapsed acute leukemia. Acta Haematol 92: 14-17
    • (1994) Acta Haematol , vol.92 , pp. 14-17
    • Keskin, A.1    Tombuloglu, M.2    Atamer, M.A.3
  • 48
    • 0028906556 scopus 로고
    • Pilot study of high-dose mitoxantrone and busulfan plus autologous bone marrow transplantation in patients with advanced malignancies
    • Khalil A, Ciobanu N, Sparano JA, et al. (1995) Pilot study of high-dose mitoxantrone and busulfan plus autologous bone marrow transplantation in patients with advanced malignancies. Bone Marrow Transplant 15: 93-97
    • (1995) Bone Marrow Transplant , vol.15 , pp. 93-97
    • Khalil, A.1    Ciobanu, N.2    Sparano, J.A.3
  • 49
    • 0028346958 scopus 로고
    • Combination of mitoxantrone and etoposide in the treatment of myelodysplastic syndromes transformed into acute myeloid leukemia
    • Knauf WU, Berdel WE, Ho AD, et al. (1994) Combination of mitoxantrone and etoposide in the treatment of myelodysplastic syndromes transformed into acute myeloid leukemia. Leuk Lymph 12: 421-425
    • (1994) Leuk Lymph , vol.12 , pp. 421-425
    • Knauf, W.U.1    Berdel, W.E.2    Ho, A.D.3
  • 50
    • 0023734751 scopus 로고
    • A new combination of two intercalating agents (mitoxantrone + daunomycin) in adult refractory acute leukemia: The DON protocol
    • Laporte JP, Gorin NC, Lemonnier MP, et al. (1988) A new combination of two intercalating agents (mitoxantrone + daunomycin) in adult refractory acute leukemia: the DON protocol. Cancer Chemother Pharmacol 22: 344-347
    • (1988) Cancer Chemother Pharmacol , vol.22 , pp. 344-347
    • Laporte, J.P.1    Gorin, N.C.2    Lemonnier, M.P.3
  • 51
    • 0023136998 scopus 로고
    • A clinical and pharmacokinetic study of mitoxantrone in acute nonlymphocytic leukemia
    • Larson RA, Daly KM, Choi KE, et al. (1987) A clinical and pharmacokinetic study of mitoxantrone in acute nonlymphocytic leukemia. J Clin Oncol 5: 391-397
    • (1987) J Clin Oncol , vol.5 , pp. 391-397
    • Larson, R.A.1    Daly, K.M.2    Choi, K.E.3
  • 52
    • 0024918203 scopus 로고
    • Mitoxantrone and etoposide: An effective regimen for refractory or relapsed acute myelogenous leukemia
    • Lazzarino M, Morra E, Alessandrino EP, et al. (1989) Mitoxantrone and etoposide: an effective regimen for refractory or relapsed acute myelogenous leukemia. Eur J Haematol 43: 411-416
    • (1989) Eur J Haematol , vol.43 , pp. 411-416
    • Lazzarino, M.1    Morra, E.2    Alessandrino, E.P.3
  • 53
    • 0025833017 scopus 로고
    • Salvage chemotherapy containing moderate-dose cytosine arabinoside and mitoxantrone for relapsed and resistant acute myeloid leukaemia
    • Liang R, Chiu E, Chan TK, et al. (1991) Salvage chemotherapy containing moderate-dose cytosine arabinoside and mitoxantrone for relapsed and resistant acute myeloid leukaemia. Cancer Chemother Pharmacol 28: 74-76
    • (1991) Cancer Chemother Pharmacol , vol.28 , pp. 74-76
    • Liang, R.1    Chiu, E.2    Chan, T.K.3
  • 54
    • 0028900863 scopus 로고
    • Intensive consolidation chemotherapy for newly diagnosed acute myeloid leukemia using a regime containing moderate dose cytosine arabinoside and mitoxantrone
    • Liang R, Chan TK, Chu YC, et al. (1995) Intensive consolidation chemotherapy for newly diagnosed acute myeloid leukemia using a regime containing moderate dose cytosine arabinoside and mitoxantrone. Anti-Cancer Drugs 6: 224-228
    • (1995) Anti-Cancer Drugs , vol.6 , pp. 224-228
    • Liang, R.1    Chan, T.K.2    Chu, Y.C.3
  • 55
    • 0025179551 scopus 로고
    • Mitoxantrone, cytosine arabinoside and VP-16 in 36 patients with relapsed and refractory acute myeloid leukemia
    • Buchner T, Schellong G, Hiddemann W, Ritter J (eds) Springer, Berlin Heidelberg New York
    • Link H, Freund M, Diedridi H, et al. (1990) Mitoxantrone, cytosine arabinoside and VP-16 in 36 patients with relapsed and refractory acute myeloid leukemia. In: Buchner T, Schellong G, Hiddemann W, Ritter J (eds) Haematology and blood transfusion. Acute leukemias II, prognostic factors and treatment strategies, vol. 33. Springer, Berlin Heidelberg New York, pp. 322-325
    • (1990) Haematology and Blood Transfusion. Acute Leukemias II, Prognostic Factors and Treatment Strategies , vol.33 , pp. 322-325
    • Link, H.1    Freund, M.2    Diedridi, H.3
  • 56
    • 0026063237 scopus 로고
    • Mitoxantrone and cytosine arabinoside as first-line therapy in elderly patients with acute myeloid leukaemia
    • Liu Yin JA, Johnson PRE, Davies JM, et al. (1991) Mitoxantrone and cytosine arabinoside as first-line therapy in elderly patients with acute myeloid leukaemia. Br J Hematol 79: 415-420
    • (1991) Br J Hematol , vol.79 , pp. 415-420
    • Liu Yin, J.A.1    Johnson, P.R.E.2    Davies, J.M.3
  • 57
    • 0010587088 scopus 로고
    • Mitoxantrone versus daunorubicin in aduction of acute myelogenous leukemia elderly patients and low-dose ara-c vs control as maintenance. An EORTC phase II trial (AML-9)
    • Löwenberg B, Fiere D, Zittoun R, et al. (1991) Mitoxantrone versus daunorubicin in aduction of acute myelogenous leukemia elderly patients and low-dose ara-c vs control as maintenance. An EORTC phase II trial (AML-9). Haematologica 76 [Suppl 4]: 91
    • (1991) Haematologica , vol.76 , Issue.4 SUPPL. , pp. 91
    • Löwenberg, B.1    Fiere, D.2    Zittoun, R.3
  • 58
    • 0021336136 scopus 로고
    • Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy
    • Lown JW, Hanstock CC, Bradley RD, et al. (1984) Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy. Mol Pharmacol 25: 178-184
    • (1984) Mol Pharmacol , vol.25 , pp. 178-184
    • Lown, J.W.1    Hanstock, C.C.2    Bradley, R.D.3
  • 59
    • 0027444911 scopus 로고
    • Mitoxantrone and cytosine arabinoside as treatment for acute myelogenous leukemia (AML) at first recurrence
    • MacCallum PK, Davis CL, Rohatiner AZS, et al.(1993) Mitoxantrone and cytosine arabinoside as treatment for acute myelogenous leukemia (AML) at first recurrence. Leukemia 7: 1496-1499
    • (1993) Leukemia , vol.7 , pp. 1496-1499
    • MacCallum, P.K.1    Davis, C.L.2    Rohatiner, A.Z.S.3
  • 60
    • 0029102899 scopus 로고
    • Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukemia in older patients
    • MacCallum PK, Robatiner AZS, Davis CL, et al.(1995) Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukemia in older patients. Ann Hematol 71: 35-39
    • (1995) Ann Hematol , vol.71 , pp. 35-39
    • MacCallum, P.K.1    Robatiner, A.Z.S.2    Davis, C.L.3
  • 61
    • 0025914062 scopus 로고
    • Multidrug resistance (MDR1) gene expression in adult leukemia: Correlation with treatment outcome and in vitro drug sensitivity
    • Marie JP, Zittoun R, Sikic BI (1991) Multidrug resistance (MDR1) gene expression in adult leukemia: correlation with treatment outcome and in vitro drug sensitivity. Blood 78: 586-592
    • (1991) Blood , vol.78 , pp. 586-592
    • Marie, J.P.1    Zittoun, R.2    Sikic, B.I.3
  • 62
    • 0026642360 scopus 로고
    • In vitro effect of P-glycoprotein (P-gp) modulators on drug sensitivity of leukemic progenitors (CFU-L) in acute myeloid leukemia (AML)
    • Marie JP, Helou C, Thevenin D, et al. (1992) In vitro effect of P-glycoprotein (P-gp) modulators on drug sensitivity of leukemic progenitors (CFU-L) in acute myeloid leukemia (AML). Exp Hematol 20: 565-568
    • (1992) Exp Hematol , vol.20 , pp. 565-568
    • Marie, J.P.1    Helou, C.2    Thevenin, D.3
  • 63
    • 0026694846 scopus 로고
    • Cost of complete remission induction in acute myeloblastic leukemia: Evaluation of the cost-effectiveness of a new drug
    • Marie JP, Wdowick T, Bisserbe S, et al. (1992) Cost of complete remission induction in acute myeloblastic leukemia: evaluation of the cost-effectiveness of a new drug. Leukemia 7: 720-722
    • (1992) Leukemia , vol.7 , pp. 720-722
    • Marie, J.P.1    Wdowick, T.2    Bisserbe, S.3
  • 64
    • 0025185703 scopus 로고
    • High-dose cytosine arabinoside and amsacrine or mitoxantrone in relapsed and refractory acute myeloid leukaemia: A prospective randomized study
    • Martiat P, Ghilain JM, Ferrant A, et al. (1990) High-dose cytosine arabinoside and amsacrine or mitoxantrone in relapsed and refractory acute myeloid leukaemia: a prospective randomized study. Eur J Haematol 45: 164-167
    • (1990) Eur J Haematol , vol.45 , pp. 164-167
    • Martiat, P.1    Ghilain, J.M.2    Ferrant, A.3
  • 65
    • 0021863767 scopus 로고
    • A phase II study of mitoxantrone in acute leukemia
    • Masoaka T, Shibata H, Oguma S, et al. (1985) A phase II study of mitoxantrone in acute leukemia. Invest New Drugs 3: 197-201
    • (1985) Invest New Drugs , vol.3 , pp. 197-201
    • Masoaka, T.1    Shibata, H.2    Oguma, S.3
  • 66
    • 0027941369 scopus 로고
    • Intensive postremission chemotherapy in adults with acute myeloid leukemia
    • Mayer RJ, Davis RB, Schiffer CA, et al. (1994) Intensive postremission chemotherapy in adults with acute myeloid leukemia. N Engl J Med 331: 896-903
    • (1994) N Engl J Med , vol.331 , pp. 896-903
    • Mayer, R.J.1    Davis, R.B.2    Schiffer, C.A.3
  • 67
    • 0026701687 scopus 로고
    • Treatment of adult acute leukemia
    • McCauley DL (1992) Treatment of adult acute leukemia. Clin Pharmacol 11: 767-796
    • (1992) Clin Pharmacol , vol.11 , pp. 767-796
    • McCauley, D.L.1
  • 69
    • 0021710431 scopus 로고
    • Mitoxantrone in the treatment of relapsed and refractory acute leukemia
    • Moore JO, Olsen GA (1984) Mitoxantrone in the treatment of relapsed and refractory acute leukemia. Semin Oncol 11 [Suppl 1]: 41-46
    • (1984) Semin Oncol , vol.11 , Issue.1 SUPPL. , pp. 41-46
    • Moore, J.O.1    Olsen, G.A.2
  • 70
    • 0018734451 scopus 로고
    • Antitumor agents. I. 1,4-bis[(aminoalkyl)amino]-9,10-anthracenediones
    • Murdock KC, Child RG, Fabio PF, et al. (1979) Antitumor agents. I. 1,4-bis[(aminoalkyl)amino]-9,10-anthracenediones. J Med Chem 22: 1024-1030
    • (1979) J Med Chem , vol.22 , pp. 1024-1030
    • Murdock, K.C.1    Child, R.G.2    Fabio, P.F.3
  • 71
    • 0025994717 scopus 로고
    • Mitoxantrone and high-dose etoposide for patients with relapsed or refractory acute leukemia
    • O'Brien S, Kantarjian H, Estey E, et al. (1991) Mitoxantrone and high-dose etoposide for patients with relapsed or refractory acute leukemia. Cancer 67: 691-694
    • (1991) Cancer , vol.67 , pp. 691-694
    • O'Brien, S.1    Kantarjian, H.2    Estey, E.3
  • 72
    • 0025178776 scopus 로고
    • Intensive induction therapy with behenoyl cytosine arabinoside, daunorubicin and 6-mercaptopurine followed by intensive consolidation with mitoxantrone, etoposide, vincristine and intermediate-dose continuous cytarabine (M-85 protocol) for adult myelogenous leukemia
    • Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Springer, Berlin Heidelberg New York
    • Ohno R, Yokomaku S, Okumura M, et al. (1990) Intensive induction therapy with behenoyl cytosine arabinoside, daunorubicin and 6-mercaptopurine followed by intensive consolidation with mitoxantrone, etoposide, vincristine and intermediate-dose continuous cytarabine (M-85 protocol) for adult myelogenous leukemia. In: Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Haematology and blood transfusion. Acute leukemias II, prognostic factors and treatment strategies, vol. 33. Springer, Berlin Heidelberg New York, p. 304-308
    • (1990) Haematology and Blood Transfusion. Acute Leukemias II, Prognostic Factors and Treatment Strategies , vol.33 , pp. 304-308
    • Ohno, R.1    Yokomaku, S.2    Okumura, M.3
  • 73
    • 0021749023 scopus 로고
    • Mitoxantrone as a single agent and in combination chemotherapy in patients with refractory acute leukemia
    • Paciucci PA, Cuttner J, Holland JF (1984) Mitoxantrone as a single agent and in combination chemotherapy in patients with refractory acute leukemia. Semin Oncol 11 [Suppl 1]: 36-40
    • (1984) Semin Oncol , vol.11 , Issue.1 SUPPL. , pp. 36-40
    • Paciucci, P.A.1    Cuttner, J.2    Holland, J.F.3
  • 74
    • 0023241984 scopus 로고
    • Mitoxantrone and ara-C in previously treated patients with acute myelogenous leukemia
    • Paciucci PA, Dutcher JP, Cuttner J, et al. (1987) Mitoxantrone and ara-C in previously treated patients with acute myelogenous leukemia. Leukemia 1: 565-567
    • (1987) Leukemia , vol.1 , pp. 565-567
    • Paciucci, P.A.1    Dutcher, J.P.2    Cuttner, J.3
  • 75
    • 0025023855 scopus 로고
    • Sequential Intermediate-Dose Cytosine Arabinoside and mitoxantrone for patients with relapsed and refractory acute myelocytic leukemia
    • Paciucci PA, Cuttner J, Holland JF (1990) Sequential Intermediate-Dose Cytosine Arabinoside and mitoxantrone for patients with relapsed and refractory acute myelocytic leukemia. Am J Hematol 35: 22-25
    • (1990) Am J Hematol , vol.35 , pp. 22-25
    • Paciucci, P.A.1    Cuttner, J.2    Holland, J.F.3
  • 76
    • 0025250622 scopus 로고
    • Mitoxantrone and constant infusion etoposide for relapsed and refractory acute myelocytic leukemia
    • Paciucci PA, Davis RB, Holland JF, et al. (1990) Mitoxantrone and constant infusion etoposide for relapsed and refractory acute myelocytic leukemia. Am J Clin Oncol 13: 516-519
    • (1990) Am J Clin Oncol , vol.13 , pp. 516-519
    • Paciucci, P.A.1    Davis, R.B.2    Holland, J.F.3
  • 77
    • 0028086285 scopus 로고
    • A randomized study of mitoxantrone plus cytarabine versus daunomycin plus cytarabine in the treatment of previously untreated adult patients with acute nonlymphocytic leukemia
    • Pavlovsky S, Gonzalez Llaven J, et al. (1994) A randomized study of mitoxantrone plus cytarabine versus daunomycin plus cytarabine in the treatment of previously untreated adult patients with acute nonlymphocytic leukemia. Ann Hematol 69: 11-15
    • (1994) Ann Hematol , vol.69 , pp. 11-15
    • Pavlovsky, S.1    Gonzalez Llaven, J.2
  • 78
    • 0021678820 scopus 로고
    • Mitoxantrone in relapsed and refractory acute leukemia
    • Prentice HG, Robbins G, Ma DF, et al. (1984) Mitoxantrone in relapsed and refractory acute leukemia. Semin Oncol 11 [Suppl 1]: 32-35
    • (1984) Semin Oncol , vol.11 , Issue.1 SUPPL. , pp. 32-35
    • Prentice, H.G.1    Robbins, G.2    Ma, D.F.3
  • 79
    • 9844260320 scopus 로고
    • Mitoxantrone (MTZ) and ARA-C high remission rate as first line therapy for acute myeloid leukemia (AML)
    • Rodriguez-Morales A, Lopez JL, Sanchez P, et al. (1991) Mitoxantrone (MTZ) and ARA-C high remission rate as first line therapy for acute myeloid leukemia (AML). Haematologica 76 [Suppl 4]: 127a
    • (1991) Haematologica , vol.76 , Issue.4 SUPPL.
    • Rodriguez-Morales, A.1    Lopez, J.L.2    Sanchez, P.3
  • 80
    • 0025157759 scopus 로고
    • Mitoxantrone and etoposide in patients with relapsed and refractory acute non-lymphocytic leukemia
    • Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Springer, Berlin Heidelberg New York
    • Rowe JM, Mazza JJ, Hines JD, et al. (1990) Mitoxantrone and etoposide in patients with relapsed and refractory acute non-lymphocytic leukemia. In: Büchner T, Schellong G, Hiddemann W, Ritter J (eds) Haematology and blood transfusion. Acute leukemias II, prognostic factors and treatment strategies, vol. 33. Springer, Berlin Heidelberg New York, p. 327-329
    • (1990) Haematology and Blood Transfusion. Acute Leukemias II, Prognostic Factors and Treatment Strategies , vol.33 , pp. 327-329
    • Rowe, J.M.1    Mazza, J.J.2    Hines, J.D.3
  • 81
    • 0024364161 scopus 로고
    • Experience with combinations containing mitoxantrone in the treatment of adult acute leukemias
    • Samir Motawy M, Salfiti R, Khalifa F, et al. (1989) Experience with combinations containing mitoxantrone in the treatment of adult acute leukemias. J Chemother 1: 123-127
    • (1989) J Chemother , vol.1 , pp. 123-127
    • Samir Motawy, M.1    Salfiti, R.2    Khalifa, F.3
  • 82
    • 0028230140 scopus 로고
    • New aspects on the pharmacokinetics of mitoxantrone and its two major metabolites
    • Schleyer E, Kamischke A, Kaufmann CC, et al. (1994) New aspects on the pharmacokinetics of mitoxantrone and its two major metabolites. Leukemia 8: 435-440
    • (1994) Leukemia , vol.8 , pp. 435-440
    • Schleyer, E.1    Kamischke, A.2    Kaufmann, C.C.3
  • 83
    • 4243338850 scopus 로고
    • Phase II study of high dose mitoxantrone based induction therapy in patients with acute myeloid leukemia
    • Seiter K, Feldman E, Beer M, et al. (1995) Phase II study of high dose mitoxantrone based induction therapy in patients with acute myeloid leukemia. Blood 86 [Suppl 1]: 780a
    • (1995) Blood , vol.86 , Issue.1 SUPPL.
    • Seiter, K.1    Feldman, E.2    Beer, M.3
  • 84
    • 0022637854 scopus 로고
    • Mitoxantrone, a new anticancer drug with significant clinical activity
    • Shenkenberg TD, Von Hoff DD (1986) Mitoxantrone, a new anticancer drug with significant clinical activity. Ann Intern Med 105:67-81
    • (1986) Ann Intern Med , vol.105 , pp. 67-81
    • Shenkenberg, T.D.1    Von Hoff, D.D.2
  • 85
    • 9344253962 scopus 로고
    • Induction and consolidation therapy with intermediate-dose cytarabine, mitoxantrone and etoposide in patients > 60 years with acute myeloid leukemia (AML)
    • Sheperd JD, Barnett MJ, Brockington DA, et al. (1995) Induction and consolidation therapy with intermediate-dose cytarabine, mitoxantrone and etoposide in patients > 60 years with acute myeloid leukemia (AML). Blood 86 [Suppl 1]: 522a
    • (1995) Blood , vol.86 , Issue.1 SUPPL.
    • Sheperd, J.D.1    Barnett, M.J.2    Brockington, D.A.3
  • 87
    • 9444257012 scopus 로고    scopus 로고
    • Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: A randomized multicenter study
    • Solary E, Witz B, Caillot D, et al. (1996) Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: a randomized multicenter study. Blood 88: 1198-1205
    • (1996) Blood , vol.88 , pp. 1198-1205
    • Solary, E.1    Witz, B.2    Caillot, D.3
  • 88
    • 0027157357 scopus 로고
    • Mitoxantrone, etoposide and intermediate-dose ara-C (MEC): An effective regimen for poor risk acute myeloid leukemia
    • Spadea A, Petti MC, Fazi P, et al. (1993) Mitoxantrone, etoposide and intermediate-dose ara-C (MEC): an effective regimen for poor risk acute myeloid leukemia. Leukemia 7: 549-552
    • (1993) Leukemia , vol.7 , pp. 549-552
    • Spadea, A.1    Petti, M.C.2    Fazi, P.3
  • 89
    • 0021192054 scopus 로고
    • Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
    • Tewey KM, Chen GL, Nelson EM, et al. (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem 259: 9182-9187
    • (1984) J Biol Chem , vol.259 , pp. 9182-9187
    • Tewey, K.M.1    Chen, G.L.2    Nelson, E.M.3
  • 91
    • 0019452594 scopus 로고
    • Phase I clinical study of dihydroanthracenedione administered on a 5 days IV schedule
    • Valdivieso M, Bedikian AY, Burgess MA, et al. (1981) Phase I clinical study of dihydroanthracenedione administered on a 5 days IV schedule. Cancer Treat Rep 65: 841-844
    • (1981) Cancer Treat Rep , vol.65 , pp. 841-844
    • Valdivieso, M.1    Bedikian, A.Y.2    Burgess, M.A.3
  • 92
    • 0020404773 scopus 로고
    • A phase II trial of mitoxantrone (DHAD, NSC-301739) in adult acute leukemia
    • Van Echo DA, Shulman PN, Ferrari A, et al. (1982) A phase II trial of mitoxantrone (DHAD, NSC-301739) in adult acute leukemia. Proc Am Soc Clin Oncol 1: 132a
    • (1982) Proc Am Soc Clin Oncol , vol.1
    • Van Echo, D.A.1    Shulman, P.N.2    Ferrari, A.3
  • 93
    • 9844260754 scopus 로고
    • Mitoxantrone in children with malignant disease
    • Rozencweig M, Von Hoff DD, Staquet MJ (eds) Raven, New York
    • Vietti TJ, Steuber P, Kim TH, et al. (1983) Mitoxantrone in children with malignant disease. In: Rozencweig M, Von Hoff DD, Staquet MJ (eds) New anticancer drugs: mitoxantrone and bisantrene. Raven, New York, pp. 93-102
    • (1983) New Anticancer Drugs: Mitoxantrone and Bisantrene , pp. 93-102
    • Vietti, T.J.1    Steuber, P.2    Kim, T.H.3
  • 94
    • 0028972612 scopus 로고
    • MEC (mitoxantrone, etoposide and intermediate-dose cytarabine): An effective induction regimen for previously untreated acute non-lymphocytic leukemia
    • Visani G, Petti MC, Cenacchi A, et al. (1995) MEC (mitoxantrone, etoposide and intermediate-dose cytarabine): an effective induction regimen for previously untreated acute non-lymphocytic leukemia. Leuk Lymph 19: 447-451
    • (1995) Leuk Lymph , vol.19 , pp. 447-451
    • Visani, G.1    Petti, M.C.2    Cenacchi, A.3
  • 95
    • 0023758317 scopus 로고
    • Mitoxantrone in relapsed or refractory acute nonlymphocytic leukemia
    • Vredenburgh JJ, McIntyre OR, Cornwell II GG, et al. (1988) Mitoxantrone in relapsed or refractory acute nonlymphocytic leukemia. Med Pediatr Oncol 16: 187-189
    • (1988) Med Pediatr Oncol , vol.16 , pp. 187-189
    • Vredenburgh, J.J.1    McIntyre, O.R.2    Cornwell II, G.G.3
  • 96
    • 0025938464 scopus 로고
    • Mitoxantrone and cytarabine versus daunorubicin and cytarabine in previously untreated patients with acute myeloid leukemia
    • Wahlin A, Hörnsten P, Hedenus M, et al. (1991) Mitoxantrone and cytarabine versus daunorubicin and cytarabine in previously untreated patients with acute myeloid leukemia. Cancer Chemother Pharmacol 28: 480-483
    • (1991) Cancer Chemother Pharmacol , vol.28 , pp. 480-483
    • Wahlin, A.1    Hörnsten, P.2    Hedenus, M.3
  • 97
    • 0023801844 scopus 로고
    • Mitoxantrone and high-dose cytosine arabinoside in refractory acute myelogenous leukemia
    • Walters RS, Kantarjian HM, Keating MJ, et al. (1988) Mitoxantrone and high-dose cytosine arabinoside in refractory acute myelogenous leukemia. Cancer 62: 677-682
    • (1988) Cancer , vol.62 , pp. 677-682
    • Walters, R.S.1    Kantarjian, H.M.2    Keating, M.J.3
  • 98
    • 9844244820 scopus 로고    scopus 로고
    • Quinine improves results of intensive chemotherapy in myelodysplastic syndromes (MDS) expressing P glycoprotein (PGP)
    • Wattel E, Solary E, Caillot D, et al. (1996) Quinine improves results of intensive chemotherapy in myelodysplastic syndromes (MDS) expressing P glycoprotein (PGP). Blood 88 [Suppl 1]: 455a
    • (1996) Blood , vol.88 , Issue.1 SUPPL.
    • Wattel, E.1    Solary, E.2    Caillot, D.3
  • 99
    • 0028196925 scopus 로고
    • Cytosine arabinoside and mitoxantrone treatment of relapsed or refractory childhood leukemia: Initial response and relationship to multidrug resistance gene 1
    • Wells RJ, Odom LF, Gold SH, et al. (1994) Cytosine arabinoside and mitoxantrone treatment of relapsed or refractory childhood leukemia: initial response and relationship to multidrug resistance gene 1. Med Pediatr Oncol 22: 244-249
    • (1994) Med Pediatr Oncol , vol.22 , pp. 244-249
    • Wells, R.J.1    Odom, L.F.2    Gold, S.H.3
  • 100
    • 0343014501 scopus 로고
    • Meta-analysis of randomized trials of idarubicin (IDAR) or mitoxantrone (MITO) versus daunorubicin (DNR) as induction therapy for acute myeloid leukaemia (AML)
    • Wheatley K (1995) Meta-analysis of randomized trials of idarubicin (IDAR) or mitoxantrone (MITO) versus daunorubicin (DNR) as induction therapy for acute myeloid leukaemia (AML). Blood 86 [Suppl 1]: 434a
    • (1995) Blood , vol.86 , Issue.1 SUPPL.
    • Wheatley, K.1
  • 101
    • 0019991734 scopus 로고
    • Comparison of cardiotoxicity of two anthracenediones and doxorubicin in rats
    • Zbinden G, Beilstein AK (1982) Comparison of cardiotoxicity of two anthracenediones and doxorubicin in rats. Toxicol Lett 11: 289-297
    • (1982) Toxicol Lett , vol.11 , pp. 289-297
    • Zbinden, G.1    Beilstein, A.K.2
  • 102
    • 0028889993 scopus 로고
    • Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia
    • Zittoun R, Mandelli F, Willemze R, et al. (1995) Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 332: 217-223
    • (1995) N Engl J Med , vol.332 , pp. 217-223
    • Zittoun, R.1    Mandelli, F.2    Willemze, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.