Normal intestinal dietary fat and cholesterol absorption, intestinal apolipoprotein B (ApoB) mRNA levels, and ApoB-48 synthesis in a hypobetalipoproteinemic kindred without any ApoB truncation

Metabolism: Clinical and Experimental

Volumn 46, Issue 9, 1997, Pages 1095-1100

  Pulai, Judit I ^b   Averna, Maurizio ^b   Srivastava, Rai Ajit K ^b   Latour, Mickey A ^b   Clouse, Ray E ^b   Ostlund, Richard E ^b   Schonfeld, Gustav ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN B48; CHOLESTEROL; RETINOL PALMITATE; TRIACYLGLYCEROL;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; GENETIC LINKAGE; HUMAN; HUMAN TISSUE; HYPOBETALIPOPROTEINEMIA; INTESTINE BIOPSY; LIPID ABSORPTION; LIPID DIET; LIPOPROTEIN METABOLISM; LIPOPROTEIN SYNTHESIS; MALE; PRIORITY JOURNAL; RNA EDITING; SEGREGATION ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0030866533     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90285-7     Document Type: Article

References (29)

1. Sharp D, Blinderman L, Combs KA, et al: Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. Nature 365:65-69, 1993
2. Wetterau JR, Aggerbeck LP, Bouma ME, et al: Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 258:999-1001, 1992
3. Bouma ME, Beucler I, Aggerbeck IP, et al: Hypobetalipoproteinemia with accumulation of an apoprotein B-like protein in intestinal cells. J Clin Invest 78:398-410, 1986
4. Pessah M, Benlian P, Beucler I, et al: Anderson's disease - Genetic exclusion of the apolipoprotein-B gene in two families. J Clin Invest 87:367-370, 1991
5. Schonfeld G: The hypobetalipoproteinemias. Annu Rev Nutr 15:23-34, 1995
6. Linton MF, Farese RV Jr, Young SG: Familial hypobetalipoproteinemia. J Lipid Res 34:521-541, 1993
7. Fazio S, Sidoli A, Vivenzio A, et al: A form of familial hypobetalipoproteinaemia is not due to a mutation in the apolipoprotein-B gene. J Intern Med 229:41-47, 1991
8. Young SG: Recent progress in understanding apolipoprotein-B, Circulation 82:1574-1594, 1990
9. Powell LM, Wallis SC, Pease RJ, et al: A novel form of tissue-specific RNA processing produces apolipoprotein B-48 in intestine. Cell 50:831-840, 1987
10. Levy E, Marcel YR, Deckelbaum J, et al: Intestinal apoB synthesis, lipids, and lipoproteins in chylomicron retention disease. J Lipid Res 28:1263-1274, 1987
11. Roy CC, Levy E, Green PHR, et al: Malabsorption, hypocholesterolemia, and fat-filled enterocytes with increased intestinal apoprotein B: Chylomicron retention disease. Gastroenterology 92:390-399, 1987
12. Glickman RM, Glickman JN, Magun A, et al: Apolipoprotein synthesis in normal and abetalipoproteinemic intestinal mucosa. Gastroenterology 101:749-755, 1991
13. Lipid Research Clinics: Population Studies Data Book: The Prevalence Study. US Department of Health and Human Services Publication No. (NIH) 80-1527, 1980
14. Averna M, Seip RL, Mankowitz K, et al: Postprandial lipemia in subjects with hypobetalipoproteinemia and a single intestinal allele for apoB-48. J Lipid Res 34:1957-1967, 1993
15. Bosner MS, Ostlund RE, Osofisan O, et al: Assessment of percent cholesterol absorption in humans with stable isotopes. J Lipid Res 34:1047-1053, 1993
16. Driscoll DM, Wynne JK, Wallis SC, et al: An in vitro system for the editing of apolipoprotein B mRNA. Cell 58:519-525, 1989
17. SAS Institute: SAS/STAT User's Guide: Statistics Version 6.10. Cary, NC, SAS Institute, 1995
18. Krul ES, Tang JJ, Kettler TS, et al: Lengths of truncated forms of apolipoprotein-B (ApoB) determine their intestinal production. Biochem Biophys Res Commun 189:1069-1076, 1992
19. Sasak VW, Buller HA, Reinhold R: Biosynthetic precursor (214 kDa) of apolipoprotein B-48 is not secreted by Caco-2 cells and normal human intestine. Biochem J 264:365-370, 1989
20. Cohn JS, Johnson EJ, Millar JS, et al: Contribution of ApoB-48 and ApoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J Lipid Res 34:2033-2040, 1993
21. Cohn JS, McNamara JR, Krasinski SD, et al: Role of triglyceride rich lipoproteins from the liver and intestine in the etiology of postprandial peaks in plasma triglyceride concentration. Metabolism 38:484-490, 1989
22. Lackner KJ, Monge JC, Gregg RE, et al: Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia. J Clin Invest 78:1707-1712, 1986
23. Ross RS, Gregg RE, Law SW, et al: Homozygous hypobetalipoproteinemia: A disease distinct from abetalipoproteinemia at the molecular level. J Clin Invest 8:590-595, 1987
24. Cooper DN: Human gene mutations affecting RNA processing and translation. Ann Med 25:11-17, 1993
25. Patel S, Pessah M, Beucler I, et al: Chylomicron retention disease: Exclusion of apolipoprotein B gene defects and detection of mRNA editing in an affected family. Atherosclerosis 108:201-207, 1994
26. Lopezmiranda J, Kam N, Osada J, et al: Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing. Biochim Biophys Acta 1214:143-147, 1994
27. Davidson NO, Magun AM, Brasitus TA, et al: Intestinal apolipoprotein A-1 and B-48 metabolism: Effects of sustained alterations in dietary triglyceride and mucosal cholesterol flux. J Lipid Res 28:388-402, 1987
28. Black DD, Hay RV, Rohwernutter PL, et al: Intestinal and hepatic apolipoprotein-B gene expression in abetalipoproteinemia. Gastroenterology 101:520-522, 1991
29. Latour MA, Patterson BW, Pulai J, et al: The metabolism of apolipoprotein B-100 in a hypobetalipoproteinemic kindred without a truncated form of apoB. J Lipid Res 38:592-599, 1997