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Volumn 148, Issue 5, 1997, Pages 301-306

Mechanisms underlying the loss of serf tolerance in NOD mice

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; HAPLOTYPE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW;

EID: 0030866527     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(97)87238-0     Document Type: Article
Times cited : (9)

References (56)
  • 1
    • 0029053581 scopus 로고    scopus 로고
    • + β islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice
    • + β islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice. J. Exp. Med., 182, 87-97.
    • J. Exp. Med. , vol.182 , pp. 87-97
    • Akhtar, I.1    Gold, J.P.2    Pan, L.-Y.3
  • 2
    • 0028273017 scopus 로고
    • Evidence for a differential avidity model of T cell selection in the thymus
    • Ashton-Rickardt, P.G., Bandeira, A., Delany, J.R. et al. (1994), Evidence for a differential avidity model of T cell selection in the thymus. Cell., 76, 651-663.
    • (1994) Cell. , vol.76 , pp. 651-663
    • Ashton-Rickardt, P.G.1    Bandeira, A.2    Delany, J.R.3
  • 3
    • 0028779842 scopus 로고
    • The pathogenesis of insulin dependent diabetes mellitus
    • Atkinson, M., Maclaren, N. (1994), The pathogenesis of insulin dependent diabetes mellitus. N. Engl. J. Med., 331, 1428-1436.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1428-1436
    • Atkinson, M.1    Maclaren, N.2
  • 4
    • 0026575236 scopus 로고
    • Secretion of IL-1 : Role of protein kinase C
    • Bakouche, O., Moreau, J.L., Lachman L.B. (1992), Secretion of IL-1 : role of protein kinase C. J. Immunol., 148, 84-91.
    • (1992) J. Immunol. , vol.148 , pp. 84-91
    • Bakouche, O.1    Moreau, J.L.2    Lachman, L.B.3
  • 5
    • 0025368646 scopus 로고
    • The role of the T cell receptor in positive and negative selection of developing T cells
    • Blackman, M., Kappler, J., Marrack, P. (1990), The role of the T cell receptor in positive and negative selection of developing T cells. Science, 248, 1335-1341.
    • (1990) Science , vol.248 , pp. 1335-1341
    • Blackman, M.1    Kappler, J.2    Marrack, P.3
  • 6
    • 43949152435 scopus 로고
    • Prevention of diabetes in the NOD mouse : Implications for therapeutic interventions in humans
    • Bowman, M.A., Leiter, E.H., Atkinson, M.A. (1994), Prevention of diabetes in the NOD mouse : implications for therapeutic interventions in humans. Immunol. Today, 15, 115-120.
    • (1994) Immunol. Today , vol.15 , pp. 115-120
    • Bowman, M.A.1    Leiter, E.H.2    Atkinson, M.A.3
  • 8
    • 0026725736 scopus 로고
    • Regulation of human monocyte DNA synthesis by colony stimulating factors, cytokines, and cyclic adenosine monophosphate
    • Cheung, D.L., Hamilton, J.A. (1992), Regulation of human monocyte DNA synthesis by colony stimulating factors, cytokines, and cyclic adenosine monophosphate. Blood, 79, 1972-1981.
    • (1992) Blood , vol.79 , pp. 1972-1981
    • Cheung, D.L.1    Hamilton, J.A.2
  • 10
    • 0026700060 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer
    • Clare-Salzler, M.J., Brooks, J., Chai, A., Herle, K.V. & Anderson, C. (1992), Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J. Clin. Invest., 90, 741-748.
    • (1992) J. Clin. Invest. , vol.90 , pp. 741-748
    • Clare-Salzler, M.J.1    Brooks, J.2    Chai, A.3    Herle, K.V.4    Anderson, C.5
  • 11
    • 0028215537 scopus 로고
    • T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
    • Critchfield, J.M., Racke, M.K., Zuniga-Pflucker, J.C. , et al. (1994), T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science, 263, 1139-1143.
    • (1994) Science , vol.263 , pp. 1139-1143
    • Critchfield, J.M.1    Racke, M.K.2    Zuniga-Pflucker, J.C.3
  • 12
    • 0023953471 scopus 로고
    • Biology of interleukin 1
    • Dinarello, C.A. (1988), Biology of interleukin 1. FASEB J., 2, 108-115.
    • (1988) FASEB J. , vol.2 , pp. 108-115
    • Dinarello, C.A.1
  • 13
    • 0026545730 scopus 로고
    • Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice
    • Gerling, I.C., Serreze, D.V., Christianson, S.W. & Leiter, E.H. (1992), Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes, 41, 1672-1676.
    • (1992) Diabetes , vol.41 , pp. 1672-1676
    • Gerling, I.C.1    Serreze, D.V.2    Christianson, S.W.3    Leiter, E.H.4
  • 14
    • 0027197436 scopus 로고
    • Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper 1 (Th1) but not on Th2 cells
    • Germann, T., Gately, M.K., Schoehaut, D.S., et al (1993), Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper 1 (Th1) but not on Th2 cells. Eur. J. Immunol., 23, 1762-1770.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1762-1770
    • Germann, T.1    Gately, M.K.2    Schoehaut, D.S.3
  • 15
    • 0029061594 scopus 로고
    • Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice
    • Gill, B.M., Jaramillo, A., Ma, L., Laupland, K.B. & Delovitch, T.L. (1995), Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. Diabetes, 44, 614-619.
    • (1995) Diabetes , vol.44 , pp. 614-619
    • Gill, B.M.1    Jaramillo, A.2    Ma, L.3    Laupland, K.B.4    Delovitch, T.L.5
  • 18
    • 0030209820 scopus 로고    scopus 로고
    • Quantitative thresholds of MHC class II I-E expressed on hematopoietically derived APC in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection
    • Hanson, M.S.,Cetkovic-Cvrlje, M., Ramiya, V.K., Atkinson, M.A. et. al. (1996), Quantitative thresholds of MHC class II I-E expressed on hematopoietically derived APC in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J. Immunol., 157, 1279-1287.
    • (1996) J. Immunol. , vol.157 , pp. 1279-1287
    • Hanson, M.S.1    Cetkovic-Cvrlje, M.2    Ramiya, V.K.3    Atkinson, M.A.4
  • 19
    • 0024314951 scopus 로고
    • Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity
    • Ishikura, H., Jayaraman, S., Kuchroo, V., Diamond, B., Saito, S. & Dorf, M.E. (1989), Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity. J. Immunol., 143, 414-419.
    • (1989) J. Immunol. , vol.143 , pp. 414-419
    • Ishikura, H.1    Jayaraman, S.2    Kuchroo, V.3    Diamond, B.4    Saito, S.5    Dorf, M.E.6
  • 20
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF) ; similarities between TNF-a and interleukin 1
    • Jacob, C.O., Aiso, S., Michie, S.A., McDevitt, H.O. & Acha-Orbea H.(1990), Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF) ; similarities between TNF-a and interleukin 1. Proc. Natl. Acad. Sci. USA, 87, 968-972.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 968-972
    • Jacob, C.O.1    Aiso, S.2    Michie, S.A.3    McDevitt, H.O.4    Acha-Orbea, H.5
  • 21
    • 0027406728 scopus 로고
    • Bone marrow abnormalities in the non-obese diabetic mouse
    • Langmuir, P., Bridgett, M., Bothwell, A. & Crispe I. (1993), Bone marrow abnormalities in the non-obese diabetic mouse. Int. Immunol., 5, 165-177.
    • (1993) Int. Immunol. , vol.5 , pp. 165-177
    • Langmuir, P.1    Bridgett, M.2    Bothwell, A.3    Crispe, I.4
  • 22
    • 0027428976 scopus 로고
    • Lymph node T-cells do not optimally transfer diabetes in NOD mice
    • Lepault, F., Faveeuw, C., Luan, J.J. & Gagnerault, M.C. (1993), Lymph node T-cells do not optimally transfer diabetes in NOD mice. Diabetes, 42, 1823-1828.
    • (1993) Diabetes , vol.42 , pp. 1823-1828
    • Lepault, F.1    Faveeuw, C.2    Luan, J.J.3    Gagnerault, M.C.4
  • 24
    • 0025322995 scopus 로고
    • Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A fl-chain or normal I-E a-chain
    • Lund, T., O'Reilly, L., Hutchings, P. et al. (1990), Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A fl-chain or normal I-E a-chain. Nature, 345, 727-729.
    • (1990) Nature , vol.345 , pp. 727-729
    • Lund, T.1    O'Reilly, L.2    Hutchings, P.3
  • 25
    • 0027431890 scopus 로고
    • CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4
    • McAuthor, J.G. & Raulet D.H. (1993), CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med., 178, 1645-1653.
    • (1993) J. Exp. Med. , vol.178 , pp. 1645-1653
    • McAuthor, J.G.1    Raulet, D.H.2
  • 26
    • 0025362072 scopus 로고
    • Direct evidence for the contribution of the unique I-Anod to the development of insulitis in non-obese diabetic mice
    • Miyazaki, T., Uno, M., Uehira, M. et al. (1990), Direct evidence for the contribution of the unique I-Anod to the development of insulitis in non-obese diabetic mice. Nature (Lond.), 345, 722-724.
    • (1990) Nature (Lond.) , vol.345 , pp. 722-724
    • Miyazaki, T.1    Uno, M.2    Uehira, M.3
  • 27
    • 0027192888 scopus 로고
    • Functional CD4 T cell subset interplay in an intact immune system
    • Murray, J.S., Madri, J., Pasqualini, T. & Bottomly, K. (1993), Functional CD4 T cell subset interplay in an intact immune system. J. Immunol., 150, 4270-4276.
    • (1993) J. Immunol. , vol.150 , pp. 4270-4276
    • Murray, J.S.1    Madri, J.2    Pasqualini, T.3    Bottomly, K.4
  • 28
    • 0027363654 scopus 로고
    • The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes
    • Parish, N.M., Chandler, P., Quartey-Papafio, R., Simpson, E. & Cooke, A. (1993), The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes. Eur. J. Immunol., 23, 2667-2675.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2667-2675
    • Parish, N.M.1    Chandler, P.2    Quartey-Papafio, R.3    Simpson, E.4    Cooke, A.5
  • 29
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul, W.E. & Seder, R.S. (1994), Lymphocyte responses and cytokines. Cell, 76, 241-251.
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.S.2
  • 30
    • 0024466764 scopus 로고
    • Genetic control of diabetogenesis in NOD/Lt mice : Development and analysis of congenic stocks
    • Prochazka, M., Serreze, D.V., Worthen, S.M. & Leiter, E.H. (1989), Genetic control of diabetogenesis in NOD/Lt mice : development and analysis of congenic stocks. Diabetes, 38, 1446-1455.
    • (1989) Diabetes , vol.38 , pp. 1446-1455
    • Prochazka, M.1    Serreze, D.V.2    Worthen, S.M.3    Leiter, E.H.4
  • 31
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM : Therapeutic intervention by immunostimulation?
    • Rabinovitch, A. (1994), Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM : therapeutic intervention by immunostimulation? Diabetes, 43, 613-621.
    • (1994) Diabetes , vol.43 , pp. 613-621
    • Rabinovitch, A.1
  • 32
    • 0027399707 scopus 로고
    • Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation in the pathway of p21ras activation
    • Rapoport, M.J., Lazurus, A.H., Jaramillo, A., Speck, E. & Delovitch, T.L. (1993), Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation in the pathway of p21ras activation. J. Exp. Med., 177, 1221-1226.
    • (1993) J. Exp. Med. , vol.177 , pp. 1221-1226
    • Rapoport, M.J.1    Lazurus, A.H.2    Jaramillo, A.3    Speck, E.4    Delovitch, T.L.5
  • 33
    • 0024314032 scopus 로고
    • Prevention of diabetes in NOD mice by injection of autoreactive T lymphocytes
    • Reich, E.P., Scaringe, D., Yagi, J., Sherwin, R.S. & Janeway, C.A. (1989), Prevention of diabetes in NOD mice by injection of autoreactive T lymphocytes. Diabetes, 38, 1647-1651.
    • (1989) Diabetes , vol.38 , pp. 1647-1651
    • Reich, E.P.1    Scaringe, D.2    Yagi, J.3    Sherwin, R.S.4    Janeway, C.A.5
  • 34
    • 0343532192 scopus 로고
    • Macrophage products mediate suppression of the syngeneic mixed lymphocyte response in NOD mice
    • Robinson, P., Cai, B., Keenan, C. & Clare-Salzler, M. (1993), Macrophage products mediate suppression of the syngeneic mixed lymphocyte response in NOD mice. Autoimmunity, 15 (suppl.), 49.
    • (1993) Autoimmunity , vol.15 , Issue.SUPPL. , pp. 49
    • Robinson, P.1    Cai, B.2    Keenan, C.3    Clare-Salzler, M.4
  • 35
    • 0025908321 scopus 로고
    • Peripheral selection of the T cell repertoire
    • Rocha, B. & Von Boehmer, H. (1991), Peripheral selection of the T cell repertoire. Science, 251, 1225-1231.
    • (1991) Science , vol.251 , pp. 1225-1231
    • Rocha, B.1    Von Boehmer, H.2
  • 36
    • 0028294682 scopus 로고
    • Positive and negative thymocyte selection induced by different concentrations of a single peptide
    • Sebzda, E., Wallace, V.A., Mayer, J., Yeung, R.S.M., Mak, T. & Ohashi, P.S. (1994), Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science, 263, 1615-1618.
    • (1994) Science , vol.263 , pp. 1615-1618
    • Sebzda, E.1    Wallace, V.A.2    Mayer, J.3    Yeung, R.S.M.4    Mak, T.5    Ohashi, P.S.6
  • 37
    • 0023879559 scopus 로고
    • Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies
    • Serreze, D.V. & Leiter, E.H. (1988), Defective activation of T suppressor cell function in Nonobese Diabetic mice. Potential relation to cytokine deficiencies. J. Immunol., 140, 3801-3807.
    • (1988) J. Immunol. , vol.140 , pp. 3801-3807
    • Serreze, D.V.1    Leiter, E.H.2
  • 38
    • 0024795364 scopus 로고
    • Immunostimulation circumvents diabetes in NOD/Lt mice
    • Serreze, D.V., Hamaguchi, K. & Leiter, E.H. (1990), Immunostimulation circumvents diabetes in NOD/Lt mice. J. Autoimmun., 2, 759-776.
    • (1990) J. Autoimmun. , vol.2 , pp. 759-776
    • Serreze, D.V.1    Hamaguchi, K.2    Leiter, E.H.3
  • 39
    • 85058206738 scopus 로고
    • Defective suppressor T cell activation in NOD/Lt mice is associated with pathogenesis and homozygous expression of H-2g7
    • Serreze, D.V. & Leiter, E.H. (1991a), Defective suppressor T cell activation in NOD/Lt mice is associated with pathogenesis and homozygous expression of H-2g7. Diabetes, 40 (suppl. 1), 49A.
    • (1991) Diabetes , vol.40 , Issue.SUPPL. 1
    • Serreze, D.V.1    Leiter, E.H.2
  • 40
    • 0025858553 scopus 로고
    • Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hematopoietic origin, but not on thymic epithelium
    • Serreze, D.V. & Leiter, EH. (1991b), Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hematopoietic origin, but not on thymic epithelium. J. Immunol., 147, 1222-1229.
    • (1991) J. Immunol. , vol.147 , pp. 1222-1229
    • Serreze, D.V.1    Leiter, E.H.2
  • 41
    • 0027173029 scopus 로고
    • Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice
    • Serreze, D.V., Gaskins, H.R. & Leiter, E.H. (1993a), Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J. Immunol., 150, 2534-2543.
    • (1993) J. Immunol. , vol.150 , pp. 2534-2543
    • Serreze, D.V.1    Gaskins, H.R.2    Leiter, E.H.3
  • 42
    • 0027443570 scopus 로고
    • Hematopoietic stem cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice : Defective regulation of cytokine receptors and protein kinase C
    • Serreze, D.V., Gaedeke, J.W. & Leiter, E.H. (1993b), Hematopoietic stem cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice : defective regulation of cytokine receptors and protein kinase C. Proc. Natl. Acad. Sci. USA, 90, 9625-9629.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9625-9629
    • Serreze, D.V.1    Gaedeke, J.W.2    Leiter, E.H.3
  • 43
    • 0028068084 scopus 로고
    • Involvement of protein kinase C and protein tyrosine kinase in lipopoly-saccharide-induced TNF-a and IL-1fl production by human monocytes
    • Shapira, L., Takashiba, S., Champagne, C., Amar, S. & Van Dyke, T.E. (1994), Involvement of protein kinase C and protein tyrosine kinase in lipopoly-saccharide-induced TNF-a and IL-1fl production by human monocytes. J. Immunol., 153, 1818-1823.
    • (1994) J. Immunol. , vol.153 , pp. 1818-1823
    • Shapira, L.1    Takashiba, S.2    Champagne, C.3    Amar, S.4    Van Dyke, T.E.5
  • 44
    • 0027340693 scopus 로고
    • An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells
    • Singer, S.M., Tisch, R., Yang, X.D. & McDevitt, H.O. (1993), An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc. Natl. Acad. Sci. USA, 90, 9566-9570.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9566-9570
    • Singer, S.M.1    Tisch, R.2    Yang, X.D.3    McDevitt, H.O.4
  • 45
    • 0027448965 scopus 로고
    • Influence of micro-bial agents on the development and prevention of autoimmune diabetes
    • Singh, B. & Rabinovitch, A. (1993), Influence of micro-bial agents on the development and prevention of autoimmune diabetes. Autoimmunity, 15, 209-213.
    • (1993) Autoimmunity , vol.15 , pp. 209-213
    • Singh, B.1    Rabinovitch, A.2
  • 47
    • 0027429150 scopus 로고
    • Failure of a protective major histocompatability complex class II molecule to delete autoreactive T cells in autoimmune diabetes
    • Slattery, R.M., Miller, J.F.A.P., Heath, W.R & Charlton, B. (1993), Failure of a protective major histocompatability complex class II molecule to delete autoreactive T cells in autoimmune diabetes. Proc. Natl. Acad. Sci. USA, 90, 10808-10810.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10808-10810
    • Slattery, R.M.1    Miller, J.F.A.P.2    Heath, W.R.3    Charlton, B.4
  • 48
    • 0028337202 scopus 로고
    • Expression of IL-1 receptor discriminates Th2 from Th1 cloned CD4+ T cells specific for plasmodium chabaudi
    • Taylor-Robinson, A.W. & Phillips, R.S. (1994), Expression of IL-1 receptor discriminates Th2 from Th1 cloned CD4+ T cells specific for Plasmodium chabaudi. Immunology, 81, 216-221.
    • (1994) Immunology , vol.81 , pp. 216-221
    • Taylor-Robinson, A.W.1    Phillips, R.S.2
  • 49
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R., Yang, X.D., Singer, S.M., Liblau, R.S., Fugger, L. & McDevitt, H.O. (1993), Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (Lond.), 366, 72-75.
    • (1993) Nature (Lond.) , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 50
    • 0026672306 scopus 로고
    • Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death
    • Ucker, D.S., Meyers, J. & Obermiller, P.S. (1992), Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol., 149, 1583-1592.
    • (1992) J. Immunol. , vol.149 , pp. 1583-1592
    • Ucker, D.S.1    Meyers, J.2    Obermiller, P.S.3
  • 51
    • 0026792768 scopus 로고
    • Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules
    • Uno, M., Miyazaki, T., Uehira, M., et al. (1991), Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules. Immunol. Lett., 31, 47-52.
    • (1991) Immunol. Lett. , vol.31 , pp. 47-52
    • Uno, M.1    Miyazaki, T.2    Uehira, M.3
  • 52
    • 0025339512 scopus 로고
    • Self-nonself discrimination by T cells
    • von Boehmer, H. & Kisielow, P. (1990), Self-nonself discrimination by T cells. Science, 248, 1369-1373.
    • (1990) Science , vol.248 , pp. 1369-1373
    • Von Boehmer, H.1    Kisielow, P.2
  • 54
    • 0026658962 scopus 로고
    • Autoimmune syndromes in major histocompatability complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes
    • Wicker, L.S., Appel, M.C., Dotta, F. et al. (1992), Autoimmune syndromes in major histocompatability complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J. Exp. Med., 176, 67-77.
    • (1992) J. Exp. Med. , vol.176 , pp. 67-77
    • Wicker, L.S.1    Appel, M.C.2    Dotta, F.3
  • 56
    • 0025735437 scopus 로고
    • Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice : Evidence of thymic T cell anergy that correlates with the onset of insulitis
    • Zipris, D., Lazarus, A.H., Crow, A.R., Hadazija, M. & Delovitch, T.L. (1991), Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice : Evidence of thymic T cell anergy that correlates with the onset of insulitis. J. Immunol., 146, 3763-3771.
    • (1991) J. Immunol. , vol.146 , pp. 3763-3771
    • Zipris, D.1    Lazarus, A.H.2    Crow, A.R.3    Hadazija, M.4    Delovitch, T.L.5


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