Propiverine hydrochloride, an anti-pollakiuric agent, inhibits the activity of actomyosin ATPase from the urinary bladder

European Journal of Pharmacology

Volumn 333, Issue 1, 1997, Pages 93-97

  Matsushima, Satoshi ^a   Inada, Hiroyasu ^a   Asai, Tomoko ^a   Naka, Michiko ^a   Tanaka, Toshio ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Actomyosin ATPase activity; Anti pollakiuric agent; Calmodulin; P 4 (1 methyl 4 piperidyl diphenylpropoxyacetate hydrochloride); Smooth muscle; Urinary bladder

Indexed keywords

CALMODULIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN KINASE; PROPIVERINE;

ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DOG; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BENZILATES; CALMODULIN; CATTLE; CONTRACTILE PROTEINS; DIALYSIS; ENZYME INHIBITORS; MUSCLE, SMOOTH; MYOSIN-LIGHT-CHAIN KINASE; MYOSINS; PROTEIN BINDING; URINARY BLADDER;

EID: 0030866349     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01109-6     Document Type: Article

References (13)

1. Hartshorne, D.J., 1987. Biochemistry of the contractile process in smooth muscle. In: Johnson, L.R. (Ed.), Physiology of the Gastrointestinal Tract, 2nd ed. Raven Press, New York, pp. 423-482.
2. Haruno A. Inhibitory effects of propiverine hydrochloride on the agonist-induced or spontaneous contractions of various isolated muscle preparations. Drug Res. 42:1992;815-817.
3. Haruno A. Effects of propiverine hydrochloride on the spontaneous contractions of isolated guinea-pig urinary bladder strip and rhythmic urinary bladder contractions of anesthetized dog. Drug Res. 42:1992;1459-1461.
4. Hathaway D.R., Haeberle J.R. Selective purification of the 20,000 Da light chains of smooth muscle myosin. Anal. Biochem. 135:1983;37-43.
5. Ikebe M., Hartshorne D.J. Proteolysis of smooth muscle myosin by Staphylococcus aureus protease: Preparation of heavy meromyosin and subfragment 1 with intact 20,000 Da light chain. Biochemistry. 24:1985;2380-2387.
6. Ikebe M., Stepinska M., Kemp B.E., Means A.R., Hartshorne D.J. Proteolysis of smooth muscle myosin light chain kinase. J. Biol. Chem. 260:1987;13828-13834.
7. Klosa J., Delmar G. Synthese von Derivaten des Bebzilsäureesters mit N-methyl-hydroxy-piperidin. J. Prakt. Chem. 16:1962;71-82.
8. Nagai M., Nakajima M., Usuda S., Iriki M. Inhibitory effect of alpha-alpha-diphenyl-alpha- propoxyacetic acid-L-methyl-4-piperidyl ester hydrochloride on the activity of the rat urinary bladder. Experientia. 39:1983;1388-1389.
9. Sasaki T., Naka M., Nakamura F., Tanaka T. Ruthenium red inhibits the binding of calcium to calmodulin required for enzyme activation. J. Biol. Chem. 267:1992;21518-21523.
10. Szymanski P.T., Strauss J.D., Doerman G., DiSalvo J., Paul R. Polylysine activates smooth muscle actin-myosin interaction without LC20 phosphorylation. Am. J. Physiol. 262:1992;C1446-C1455.
11. Tanaka T., Naka M., Hidaka H. Activation of myosin light chain kinase by trypsin. Biochem. Biophys. Res. Commun. 92:1980;313-318.
12. Tokuno H., Chowdhury J.U., Tomita T. Inhibitory effects of propiverine on rat and guinea pig urinary bladder muscle. Naunyn-Schmiedebergs Arch. Pharmacol. 348:1993;659-662.
13. Yazawa M., Sakuma M., Yagi K. Calmodulin from muscle of marine invertebrates, scallop and sea anemone. J. Biochem. 87:1980;1313-1320.