Genetic variation in factor VII associated with variation in plasma lipoprotein(a) concentration

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 9, 1997, Pages 1701-1706

  Hegele, Robert A ^a   Breckenridge, W Carl ^b   Brunt, J Howard ^c   Connelly, Philip W ^a,d  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF VICTORIA   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Coagulation; Lipids; Polygenic traits; Small effects; Thrombolysis

Indexed keywords

APOLIPOPROTEIN A; BLOOD CLOTTING FACTOR 7; LIPOPROTEIN A;

ALLELE; ARTICLE; CONTROLLED STUDY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; PHENOTYPE; PRIORITY JOURNAL;

EID: 0030866055     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.9.1701     Document Type: Article

References (22)

1. Utermann G. Lipoprotein(a). In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds). The metabolic basis of inherited disease. New York: McGraw Hill; 1986:1887-1912.
2. Rhoads GG, Dahlen GH, Berg K, Morion NE, Dannenberg AL. Lp(a) lipoprotein as a risk factor for myocardial infarction. JAMA. 1986;256:2540-2544.
3. Armstrong VW, Cremer P, Eberle E, Manke A, Schulze F, Wieland H, Kreuzer H, Seidel D. The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis: dependence on serum LDL levels. Atherosclerosis. 1986;62: 249-257.
4. Rosengren A, Wilhelmsen L, Erikson E, Risberg B, Wedel H. Lipoprotein(a) and coronary heart disease: a prospective case-control study in a general population sample of middle aged men. Br Med J. 1990;310:1248-1251.
5. Sandholzer C, Boerwinkle E, Saha N, Tong MC, Utermann G. Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for a role of the apo(a) gene in coronary heart disease. J Clin Invest. 1992;89:1040-1046.
6. Bostom AG, Cupples A, Jenner JL, Ordovas JM, Seman LJ, Wilson PWF, Schaefer EJ, Castelli WP. Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger: a prospective study. JAMA. 1996;276:544-548.
7. Jauhtainen M, Koskinen P, Enholm C, Frick MM, Mantarri M, Manninen V, Huttunen JK. Lipoprotein(a) and coronary heart disease: a nested case-control study of the Helsinki Heart Study participants. Atherosclerosis. 1991;89:59-67.
8. Ridker PM, Hennekens CH, Stampfer MJ. A prospective study of lipoprotein(a) and the risk of myocardial infarction. JAMA. 1993; 270:2195-2199.
9. Moliterno DJ, Jokinen EV, Miserez AR, Lange RA, Willard JE, Boerwinkle E, Hillis LD, Hobbs HH. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. Arterioscler Thromb Vase Biol. 1995;15:850-855.
10. Albers JJ, Marcovina SM, Lodge MS. The unique lipoprotein(a): properties and immunological measurement. Clin Chem. 1990;36: 2019-2026.
11. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation on plasma lipoprotcin(a) concentrations. J Clin Invest. 1992;90:52-60.
12. Helmhold M, Bigge J, Muche R, Maino J, Thiery J, Seidel D, Armstrong VW. Contribution of the apo(a) phenotype to plasma Lp(a) concentration shows considerable ethnic variation. J Lipid Res. 1991;32:1928-1933.
13. Sandholzer C, Mailman DM, Saha N, Sigurdsson G, Lackner C, Csaszar A, Boerwinkle E, Utermann G. Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in seven ethnic groups. Hum Genet. 1991;86:614-619.
14. Marcovina SM, Albcrs JJ, Jacobs DR Jr, Perkins LL, Lewis CE, Howard BV, Savage P. Lipoprotein(a) concentrations and apolipoprotein(a) phenotypes in Caucasians and African Americans: the CARDIA Study. Arterioscler Thromb. 1993;13:1045-1050.
15. McLean JW, Tomlinson JE, Kuang W-J, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature. 1987;330: 132-137.
16. Boerwinkle E, Menzel HG, Kraft HG, Utermann G. Genetics of the quantitative Lp(a) trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation. Hum Genet. 1989;82:73-78.
17. Austin MA, Sandholzer C, Selby JV, Newman B, Krauss RM, Utermann G. Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes. Am J Hum Genet. 1992; 51:829-840.
18. Kraft HG, Kochl S, Menzel HJ, Sandholzer C, Utermann G. The apolipoprotein(a) gene: a transcribed hypervariable locus controlling plasma lipoprotein(a) concentration. Hum Genet. 1992;90: 220-230.
19. DeMeester CA, Bu X, Gray RJ, Lusis AJ, Rotter JI. Genetic variation in lipoprotein(a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein(a) gene locus. Am J Hum Genet. 1995;56:287-295.
20. Cohen JC, Chiesa G, Hobbs HH. Sequence polymorphisms in the apolipoprotein(a) gene: evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels. J Clin Invest. 1993;91:1630-1636.
21. Perombelon YFN, Soutar AK, Knight BL. Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) slides. J Clin Invest. 1994;93:1481-1492.
22. Zysow BR, Lindahl GE, Wade DP, Knight BL, Lawn RM. GT polymorphism in the 5' untranslated region of the apolipoprotein (a) gene introduces an upstream ATG and reduces in vitro translation. Arterioscler Thromb Vase Biol 1995:15:58-64.