Skewed T-cell receptor Vβ8.2 expression in transgenic CD2-myc induced thymic lymphoma: A role for antigen stimulation in tumour development?

British Journal of Cancer

Volumn 76, Issue 6, 1997, Pages 739-746

  Webster, G ^a,b   Onions, D E ^a   Neil, J C ^a   Cameron, E R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

CD2 myc; Endogenous antigen; Positive selection; Thymic lymphoma; V gene usage

Indexed keywords

CD2 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE ACTIVATION; IMMUNOSTIMULATION; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE MYC; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS LYMPHOMA; TRANSGENE;

EID: 0030865004     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.455     Document Type: Article

References (31)

1. Anderson SJ and Perlmutter RM (1995) A signalling pathway governing early thymocyte maturation. Immunol Today 16: 99-105
2. Bahler DW and Levy R (1992) Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA 89: 6670-6674
3. Blyth K, Terry A, O'Hara M, Baxter EW, Campbell M, Stewart M, Donehower LA, Onions DE, Neil JC and Cameron ER (1995) Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene 10: 1717-1723
4. Born W, White J, Kappler J and Marrack P (1988) Rearrangement of IgH genes in normal thymocyte development. J Immunol 140: 3228-3232
5. + tumours in CD2-myc transgenic mice. Br J Cancer 73: 13-17
6. Coligan JE, Kruisbeek, AM, Margulies DH, Shevach EM and Strober W (1994) Current Protocols in Immunology AI. 21. John Wiley & Sons: New York
7. Dighiero G, Hart S, Lim L, Levy R and Miller RA (1991) Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas. Blood 73: 581-585
8. Fulton R, Forrest D, McFarlane R, Onions D and Neil JC (1987) Retroviral transduction of T-cell antigen receptor β chain and myc genes. Nature 326: 190-194
9. Harris AW, Bath ML, Rosenbaum H, McNeall J, Adams JM and Cory S (1990) Lymphoid tumorigenesis by v-abl and BCR-v-abl in transgenic mice. Curr Topic Microbiol Immunol 166: 165-173
10. Hedrick SM, Cohen DI, Nielsen EA and Davis MM (1984) Isolation of cDNA clones encoding T cell-specific membrane associated proteins. Nature 308: 149-153
11. Hussell T, Isaacson PG, Crabtree JE and Spencer J (1993) Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. Lancet 342: 571-574
12. Kappler JW, Staerz U, White J and Marrack PC (1988) Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35-40
13. Kubo RT, Born W, Kappler JW, Marrack P and Pigeon M (1989) Characterisation of a monoclonal antibody which detects all murine α/β T cell receptors. J Immunol 142: 2736-2742
14. Lucas B, Vasseur F and Penit C (1993) Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes. J Immunol 151:4574-4582
15. Lucas B, Vasseur F and Penit C (1994) Production, selection and maturation of thymocytes with high surface density of TCR. J Immunol 153: 53-62
16. Marcu KB, Banerji J, Penncavage NA, Lang R and Arnheim N (1980) 5′ flanking region of immunoglobulin heavy chain constant region gene displays length heterogeneity in germ lines of inbred mouse strains. Cell 22: 187-196
17. McGrath MS and Weissman IL (1979) AKR leukemogenesis: identification and biological significance of thymic lymphoma receptors for AKR retroviruses. Cell 17: 65-75
18. γ. lymphoma surface IgM. J Mol Cell Immunol 3: 227-242
19. Nanda NK and Sercarz EE (1993) Constrained V gene choice. Current Biology 3: 484-486
20. Neil JC, Hughes D, McFarlane R, Wilkie NM, Onions DE, Lees G and Jarrett O (1984) Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukaemias. Nature 308: 814-820
21. Palacios R and Samaridis J (1991) Rearrangement patterns of T-cell receptor genes in the spleen of athymic (nu/nu) young mice. Immunogenetics 33: 90-95
22. Pannetier C, Even J and Kourilsky P (1995) T-cell receptor diversity and clonal expansion in normal and clinical samples. Immunol Today 16: 176-181
23. Rosenbaum H, Harris AW, Bath ML, McNeall J, Webb E, Adams JM and Cory S (1990) An Eμ-v-abl transgene elicits plasmacytomas in concert with an activated myc gene. EMBO 9: 897-905
24. Scherer MT, Ignatowicz L, Pullen A, Kappler J and Marrack P (1995) The use of mammary tumour virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J Exp Med 182: 1493-1504
25. Scollay R and Godfrey DI (1995) Thymic emigration: conveyor belts or lucky dips? Immunol Today 6: 268-272
26. Simpson E, Takacs K and Altman DM (1994) Thymic repertoire selection by superantigens: presentation by human and mouse MHC molecules. Thymus 23: 1-13
27. Stewart M, Cameron E, Campbell M, McFarlane R, Toth S, Lang K, Onions D and Neil JC (1993) Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region. Int J Cancer 53: 1023-1030
28. Weissinger EM, Mischak H, Largaespada DA, Kaehler DA, Mitchell T, Smith-Gill SJ, Risser R and Mushinski JF (1991) Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc. Proc Natl Acad Sci USA 88: 8735-8739
29. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, De Boni M and Isaacson PG (1993) Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid-tissue type after eradication of Helicobacterpylori. Lancet 342: 575-577
30. Yamashita I, Nagata T, Tada T and Nakayama T (1993) CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int Immunol 5: 1139-1150
31. Zelenetz AD, Chen TT and Levy R (1992) Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med 176: 1137-1148