erbB-2 oncoprotein expression in breast carcinoma: Poor prognosis associated with high degree of cytoplasmic positivity using CB-11 antibody

American Journal of Clinical Pathology

Volumn 108, Issue 4, 1997, Pages 456-463

  Keshgegian, Albert A ^a   Cnaan, Avital ^b  

^a BRYN MAWR HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Breast cancer; CB 11 antibody; erbB 2 oncoprotein; Immunohistochemistry; Prognosis

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CB 11; ONCOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CANCER MORTALITY; CANCER RECURRENCE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; ONCOGENE NEU; PRIORITY JOURNAL; PROGNOSIS;

EID: 0030863068     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/108.4.456     Document Type: Article

References (7)

1. NIH Consensus Conference. Treatment of early-stage breast cancer. JAMA. 1991;265:391-395.
2. McGuire WL, Clark GM. Prognostic factors and treatment decisions in axillary-node-negative breast cancer. N Engl J Med. 1992;26:1756-1761.
3. Hynes NE. Amplification and overexpression of the erbB-2 gene in human tumors: its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy. Semin Cancer Biol. 1993;4:19-26.
4. Gullick WJ. The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancer. Int J Cancer. 1990;suppl 5:55-61.
5. Corbett IP, Henry JA, Angus B, et al. NCL-CB11: a new monoclonal antibody recognizing the internal domain of the c-erbB-2 oncogene protein effective for use on formalin-fixed, paraffin-embedded tissue. J Pathol 1990;161:15-25.
6. Singleton TP, Niehans GA, Gu F, et al. Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry. Hum Pathol 1992;23:1141-1150.
7. DePotter CR, Van Daele S, Van De Vijver MJ, et al. The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues. Histopathology. 1989;15:351-362.