Effects of a novel guanylate cyclase inhibitor on nitric oxide-dependent inhibitory neurotransmission in canine proximal colon

British Journal of Pharmacology

Volumn 122, Issue 6, 1997, Pages 1223-1229

  Franck, H ^a   Sweeney, K M ^a   Sanders, K M ^a   Shuttleworth, C W R ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Colon; Cyclic GMP; Enteric nervous system; Gastrointestinal motility; Guanylate cyclase; Nitric oxide; ODQ; Sodium nitroprusside

Indexed keywords

8 BROMO CYCLIC GMP; ATROPINE; GUANYLATE CYCLASE INHIBITOR; HISTAMINE; INDOMETACIN; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CONTROLLED STUDY; DOG; ELECTROSTIMULATION; FEMALE; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; COLON; CYCLIC GMP; DOGS; ELECTRIC STIMULATION; ENZYME INHIBITORS; FEMALE; GUANYLATE CYCLASE; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEURONS; NITRIC OXIDE; NITROPRUSSIDE; OXADIAZOLES; QUINOXALINES;

EID: 0030862196     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701487     Document Type: Article

References (42)

1. BARBIER, A.J.M. & LEFEBVRE, R.A. (1992). Effect of LY83583 on relaxation induced by non-adrenergic non-cholinergic nerve stimulation and exogenous nitric oxide in the rat gastric fundus. Eur. J. Pharmacol., 21, 331-334.
2. BARNETTE, M., TORPHY, T.J., GROUS, M., FINE, C. & ORMSBEE, H.S. (1989). Cyclic GMP: a potential mediator of neurally- and drug-induced relaxation of opossum lower esophageal sphincter. J. Pharmacol. Exp. Ther., 249, 524-528.
3. BOLOTINA, V.M., NAJIBI, S., PALACINO, J.J., PAGANO, P.J. & COHEN, R.A. (1994). Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature, 368, 850-853.
4. BOULTON, C.L., SOUTHAM, E. & GARTHWAITE, J. (1995). Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience, 69, 699-703.
5. BREDT, D.S. & SNYDER, S.H. (1992). Nitric oxide, a novel neuronal messenger. Neuron, 8, 3-11.
6. BRUNNER, F., SCHMIDT, K., NIELSEN, E.B. & MAYER, B. (1996). Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery. J. Pharmacol. Exp. Ther., 277, 48-53.
7. BRUNNER, F., STESSEL, H. & KUKOVETZ, W.R. (1995). Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion. FEBS Lett., 376, 262-266.
8. CELLEK, S., KASAKOV, L. & MONCADA, S. (1996). Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase. Br. J. Pharmacol., 118, 137-140.
9. CHAKDER, S. & RATTAN, S. (1993). Involvement of cAMP and cGMP in relaxation of internal anal sphincter by neural stimulation, VIP, and NO. Am. J. Physiol., 261, G702-G707.
10. CONKLIN, J.L. & DU, C. (1992). Guanylate cyclase inhibitors: effect on inhibitory junction potentials in esophageal smooth muscle. Am. J. Physiol., 263, G87-G90.
11. DALZIEL, H.H., THORNBURY, K.D., WARD, S.M. & SANDERS, K.M. (1991). Involvement of nitric oxide synthetic pathway in inhibitory junction potentials in canine proximal colon. Am. J. Physiol., 269, G789-G792.
12. GARTHWAITE, J. & BOULTON, C.L. (1995). Nitric oxide signalling in the central nervous system. Ann. Rev. Physiol., 57, 683-706.
13. GARTHWAITE, J., SOUTHAM, E., BOULTON, C.L., NIELSEN, E.B., SCHMIDT, K. & MAYER, B. (1995). Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol. Pharmacol., 48, 184-188.
14. HUIZINGA, J.D., TOMLINSON, J. & PINTIN-QUEZADA, J. (1992). Involvement of nitric oxide in nerve-mediated inhibition and action of vasoactive intestinal peptide in colonic smooth muscle. J. Pharmacol. Exp. Ther., 260, 803-808.
15. JIN, J.G., MURTHY, K.S., GRIDER, J.R. & MAKHLOUF, G.M. (1993). Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells. Am. J. Physiol., 264, G470-G477.
16. KEEF, K.D., MURRAY, D.C., SANDERS, K.M. & SMITH, T.K. (1997). Basal release of nitric oxide induces oscillatory motor pattern in canine colon. J. Physiol. (Lond.), 499, 773-786.
17. KEEF, K.D., SHUTTLEWORTH, C.W., XUE, C., BAYGUINOV, O., PUBLICOVER, N.G. & SANDERS, K.M. (1994). Relationship between nitric oxide and vasoactive intestinal polypeptide in enteric inhibitory neurotransmission. Neuropharmacology, 33, 1303-1314.
18. KOH, S.D., CAMPBELL, J.D., CARL, A. & SANDERS, K.M. (1995). Nitric oxide activates multiple potassium channels in canine colonic smooth muscle. J. Physiol. (Lond.), 489, 735-743.
19. LINCOLN, T.M. & CORNWELL, T.L. (1993). Intracellular cyclic GMP receptor proteins. FASEB J., 7, 328-338.
20. LIU, L.W., THUNEBERG, L., DANIEL, E.E. & HUIZINGA, J.D. (1993). Selective accumulation of methylene blue by interstitial cells of Cajal in canine colon. Am. J. Physiol., 264, G64-G73.
21. LUO, D., DAS, S. & VINCENT, S.R. (1995). Effects of methylene blue and LY83583 on neuronal nitric oxide synthase and NADPH-diaphorase. Eur. J. Pharmacol., 290, 247-251.
22. MAYER, B., BRUNNER, F. & SCHMIDT, K. (1993). Inhibition of nitric oxide synthesis by methylene blue. Biochem. Pharmacol., 45, 367-374.
23. MEULEMANS, A.L., HELSEN, L.F. & SCHUURKES, J.A. (1993). Role of NO in vagally-mediated relaxations of guinea-pig stomach. Naunyn Schmiedeberg's Arch. Pharmacol., 347, 225-230.
24. MONCADA, S., PALMER, R.M. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharm. Rev., 43, 109-142.
25. MULSCH, A., BUSSE, R., LIEBAU, S. & FORSTERMANN, U. (1988). LY83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J. Pharm. Exp. Ther., 247, 283-288.
26. NISHIMURA, J. & VAN BREEMEN, C. (1989). Direct regulation of smooth muscle contractile elements by second messengers. Biochem. Biophys. Res. Commun., 163, 929-935.
27. RAE, M.G. & MUIR, T.C. (1996). Neuronal mediators of inhibitory junction potentials and relaxation in the guinea-pig internal anal sphincter. J. Physiol. (Lond.), 493, 512-527.
28. SANDERS, K.M., BURKE, E.P. & STEVENS, R.J. (1989). Effects of methylene blue on rhythmic activity and membrane potential in the canine proximal colon. Am. J. Physiol., 256, G779-G784.
29. SANDERS, K.M. & SMITH, T.K. (1986). Enteric neural regulation of slow waves in circular muscle of the canine proximal colon. J. Physiol. (Lond.), 377, 297-313.
30. SANDERS, K.M. & WARD, S.M. (1992). Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am. J. Physiol., 262, G379-G392.
31. SHUTTLEWORTH, C.W.R., BURNS, A.J., WARD, S.M., O'BRIEN, W.E. & SANDERS, K.M. (1995). Recycling of L-citrulline to sustain nitric oxide-dependent enteric neurotransmission. Neuroscience, 68, 1295-1304.
32. SHUTTLEWORTH, C.W. & SANDERS, K.M. (1996). Involvement of nitric oxide in neuromuscular transmission in canine proximal colon. Proc. Soc. Exp. Biol. Med., 211, 16-23.
33. SHUTTLEWORTH, C.W., SANDERS, K.M. & KEEF, K.D. (1993a). Inhibition of nitric oxide synthesis reveals non-cholinergic excitatory neurotransmission in the canine proximal colon. Br. J. Pharmacol., 109, 739-747.
34. SHUTTLEWORTH, C.W., XUE, C., WARD, S.M., DE VENTE, J. & SANDERS, K.M. (1993b). Immunohistochemical localization of 3′,5′-cyclic guanosine monophosphate in the canine proximal colon: responses to nitric oxide and electrical stimulation of enteric inhibitory neurons. Neuroscience, 56, 513-522.
35. SMITH, T.K., REED, J.B. & SANDERS, K.M. (1987). Origin and propagation of electrical slow waves in circular muscle of canine proximal colon. Am. J. Physiol., 252, C215-C224.
36. SUTHAMNATPONG, N., MAEHARA, T., KANADA, A., TAKEUCHI, T. & HATA, F. (1993). Dissociation of cyclic GMP level from relaxation of the distal, but not the proximal colon of rats. Japn. J. Pharmacol., 62, 387-393.
37. THORNBURY, K.D., WARD, S.M., DALZIEL, H.H., CARL, A., WESTFALL, D.P. & SANDERS, K.M. (1991). Nitric oxide and nitrosocysteine mimic nonadrenergic, noncholinergic hyperpolarization in canine proximal colon. Am. J. Physiol., 261, G553-G557.
38. TORPHY, T.J., FINE, C.F., BURMAN, M., BARNETTE, M.S. & ORMSBEE, H.S. (1986). Lower esophageal sphincter relaxation is associated with increased cyclic nucleotide content. Am J Physiol., 251, G786-G793.
39. WARD, S.M., DALZIEL, H.H., BRADLEY, M.E., BUXTON, I.L., KEEF, K., WESTFALL, D.P. & SANDERS, K.M. (1992a). Involvement of cyclic GMP in non-adrenergic, non-cholinergic inhibitory neurotransmission in dog proximal colon. Br. J. Pharmacol., 107, 1075-1082.
40. WARD, S.M., DALZIEL, H.H., THORNBURY, K.D., WESTFALL, D.P. & SANDERS, K.M. (1992b). Nonadrenergic, noncholinergic inhibition and rebound excitation in canine colon depend on nitric oxide. Am. J. Physiol., 262, G237-G243.
41. YANO, S., KIYOTA, Y., YAMAMOTO, M. & WATANABE, K. (1995). Pharmacological features of non-adrenergic non-cholinergic (NANC) relaxation induced by electrical vagal stimulation in isolated mouse stomach. Japn. J. Pharmacol., 69, 9-15.
42. YOUNG, H.M., CIAMPOLI, D., JOHNSON, P.J. & STEBBING, M.J. (1996). Inhibitory transmission to the longitudinal muscle of the mouse caecum is mediated largely by nitric oxide acting via guanylyl cyclase. J. Auton. Ner. Syst., 61, 103-108.