Protoporphyrin-IX distribution and photodynamic effect in rat oesophagus after aminolaevulinic acid administration

Scandinavian Journal of Gastroenterology

Volumn 32, Issue 7, 1997, Pages 633-637

  Makinen K ^a   Gronlund Pakkanen S ^b   Tiirikainen, M ^b   Nuutinen, P ^b   Kuusisto, A ^b   Alhava, E ^b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

Aminolaevulinic acid; Cancer; Oesophagus; Photochemotherapy; Protoporphyrins

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; ESOPHAGUS INJURY; FLUORESCENCE MICROSCOPY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOMETRY; PRIORITY JOURNAL; RAT; THERMAL INJURY;

EID: 0030861830     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365529708996510     Document Type: Article

References (13)

1. Evrard S, Aprahamian M, Marescaux J. Intra-abdominal photodynamic therapy: from theory to feasibility. Br J Surg 1993;80: 298-303.
2. Chatlani PT, Nuutimen PJO, Toda N, Barr H, MacRoberts AJ, Bedwell J, et al. Selective necrosis in hamster pancreatic tumours using photodynamic therapy with phtalocyanine photosensitization. Br J Surg 1992;79:786-90.
3. Murray RK. Porphyrins & bile pigments. In: Murray RK, Granner DK, Mayes PA, Rodwell VW, editors. Harper's biochemistry. East Norwalk (CT): Appleton & Lange; 1990. p. 318-31.
4. Loh CS, Vernon D, MacRobert AJ, Bedwell J, Bown SG, Brown SB. Endogenous porphyrin distribution induced by 5-aminolevulinic acid in the tissue layers of the gastrointestinal tract. J Photochem Photobiol [Biol] 1993;20:47-54.
5. Loh CS, MacRobert AJ, Bedwell J, Regula J, Krasner N, Bown SG. Oral versus intravenous administration of 5-aminolevulinic acid for photodynamic therapy. Br J Cancer 1993;68:41-51.
6. Bedwell J, MacRobert AJ, Phillips D, Bown SG. Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model. Br J Cancer 1992;65:818-24.
7. Savitski AP, Vorobyova EV, Berezin IV, Ugarova NN. Acid-base properties of protoporphyrin IX; its dimethyl ester and heme solubilized on surfactant micelles: spectrophotometric and fluorometric titration. J Colloid Interface Sci 1981;84:175-81.
8. Loh CS, Bedwell J, MacRobert AJ, Krasner N, Phillips D, Bown SG. Photodynamic therapy of the normal rat stomach: a comparative study between disulphonated aluminium phtalocyanine and 5-aminolevulinic acid. Br J Cancer 1992;66:452-62.
9. Karanov S, Shopova M, Getov H. Photodynamic therapy in gastrointestinal cancer. Lasers Surg Med 1991;11:395-8.
10. Overholt B, Panjehpour M, Tefftellar E, Rose M. Photodynamic therapy for treatment of early adenocarcinoma in Barrett's esophagus. Gastrointest Endosc 1993;39:73-6.
11. Overholt BF, Panjehpour M. Photodynamic therapy for Barrett's esophagus: Clinical update. Am J Gastroenterol 1996;91:1719-23.
12. Regula J, MacRobert AJ, Gorchein A, Buonaccorsi GA, Thorpe SM, Spencer GM, et al. Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolevulinic acid induced protoporphyrin IX - a pilot study. Gut 1995;36:67-75.
13. Barr H, Tralau CJ, MacRobert AJ, Krasner N, Boulos PB, Clark CG, et al. Photodynamic therapy in the normal rat colon with phthalocyanine sensitation. Br J Cancer 1987;56:111-8.