A new 1,2,3-triazolo[1,2]benzodiazepine ring system

Tetrahedron Letters

Volumn 38, Issue 28, 1997, Pages 5037-5040

  Knight, David W ^a   Little, Paul B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 TRIAZOLO[1,2]BENZODIAZEPINE; ALCOHOL; BENZODIAZEPINE DERIVATIVE; MANGANESE; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; ANION TRANSPORT; ARTICLE; DRUG ALCOHOL INTERACTION; MOLECULAR DYNAMICS; OXIDATION; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 0030861812     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01064-2     Document Type: Article

References (12)

1. Li, S.K.Y.; Knight, D.W. and Little, P.B. Tetrahedron Lett., 1996, 37, 5615.
2. For a review of this type of directed metallation, see Clark, R.D. Org. React., 1995, 47, 1.
3. Birkett, M.A.; Knight, D.W. and Mitchell, M.B. Tetrahedron Lett., 1993, 34, 6935, 6939; Birkett, M.A.; Knight, D.W. and Mitchell, M.B. Synlett., 1994, 253.
4. Birkett, M.A.; Knight, D.W. and Mitchell, M.B. Tetrahedron Lett., 1993, 34, 6935, 6939; Birkett, M.A.; Knight, D.W. and Mitchell, M.B. Synlett., 1994, 253.
5. Campbell, C.D.; Rees, C.W. J. Chem. Soc., Chem. Commun., 1965, 192.
6. 4 m.p. 84°C].
7. Satisfactory spectroscopic and analytical data have been obtained for all compounds reported herein.
8. Attenburrow, J; Cameron, A.F.B; Chapman, J.H; Evans, R.M; Hems, B.A.; Jansen, A.B.A.; Walker, T. J. Chem. Soc., 1952, 1094.
9. We are grateful to Professor M.B. Hursthouse and Mr D.E. Hibbs (Cardiff University) for these data, full details of which will be published elsewhere.
10. B), 4.84 (1H, m, 5-H), 7.51 (1H, app. t, J ca. 7.9, 9-H), 8.29 (1H, d, J 7.5) and 8.32 (1H, d, J 8.2).
11. Trost, B.M. Angew. Chem., Int. Ed. Engl., 1989, 28, 1173.
12. W have recently found that even the use of ethyl acetate as a solvent for column chromatography of N-Boc-1-aminobenzotriazole derivatives is unwise, due to variable amounts of N-acetylation.