Insulin signaling

Western Journal of Medicine

Volumn 167, Issue 3, 1997, Pages 166-173

  Goalstone, Marc L ^a,b   Draznin, Boris ^a,b  

^a Univ of Colorado Hlth Sci Center ^*

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANS TRANSFERASE; GERANYLTRANSFERASE; GROWTH FACTOR; INSULIN; INSULIN RECEPTOR; MEVALONIC ACID;

CONFERENCE PAPER; ENZYME ACTIVATION; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HYPERINSULINEMIA; LIPOGENESIS; SIGNAL TRANSDUCTION;

BLOOD GLUCOSE; HUMANS; INSULIN; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSFERASES;

EID: 0030861636     PISSN: 00930415     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. Fiakoll P, Carlson MG, Cherrington A. Physiologic action of insulin. In LeRoith D, Taylor SI, Olefsky JM, (Eds): Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott-Raven, 1996, pp 121-132
2. Kahn CR. The molecular mechanism of insulin action. Ann Rev Med 1985; 36:429-451
3. Olefsky JM. The insulin receptor: A multi-functional protein. Diabetes 1990; 39:1009-1016
4. Kahn CR, White MF. The insulin receptor and the molecular mechanism of insulin action. J Clin Invest 1988; 82:1151-1156
5. Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, et al. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signaling. Cell 1985; 40:747-758
6. Kasuga MF, Karlsson A, Kahn CR. Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science 1982; 215:185-186
7. White MF, Shoelson SE, Kentmann H, Kahn CR. A cascade of tyrosine autophosphorylation in the β subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 1993; 268:4092-4098
8. S. Sun XJ, Miralpeix M, Myers MG Jr, Glasheen EM, Backer JM, Kahn CR, et al. The expression and function of IRS-1 in insulin signal transmission. J Biol Chem 1992; 267:22662-22672
9. Sasaoka T, Draznin B, Leitner JW, Langlois WJ, Olefsky JM. She is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. J Biol Chem 1994; 269:10734-10738
10. Pawson T, Gish GD. SH2 and SH3 domains: from structure to function. Cell 1992; 71:359-362
11. Myers MG Jr. White MF. Insulin signal transduction and the IRS proteins. Ann Rev Pharmacol Toxicol 1996; 36:615-658