Purpose and guidelines for toxicokinetic studies within the National Toxicology Program

Environmental Health Perspectives

Volumn 105, Issue 5, 1997, Pages 468-471

  Buchanan, J Robert ^a   Burka, Leo T ^b   Melnick, Ronald L ^b  

^a MILLERSVILLE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

PBPK modeling; Study design; Toxicokinetics

Indexed keywords

CARCINOGENICITY; METABOLISM; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK ASSESSMENT; SHORT SURVEY; TOXICITY TESTING;

ANIMALIA;

EID: 0030861539     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.2307/3433566     Document Type: Short Survey

References (4)

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2. Gargas ML. Chemical-specific constants for physiologically-based pharmacokinetic models. Technical report 11. Research Triangle Park, NC:Chemical Industry Institute of Toxicology, 1991.
3. Sato A, Nakajima T. A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons. Toxicol Appl Pharmacol 47:41-46 (1979).
4. Jepson GW, Hoover DK, Black RK, McCafferty JD, Mahle DA, Gearhart JM. A partition coefficient determination method for nonvolatile chemicals in biological tissues. Fundam Appl Toxicol 22:519-524 (1994).