Gepirone and diazepam in generalized anxiety disorder: A placebo-controlled trial

Journal of Clinical Psychopharmacology

Volumn 17, Issue 4, 1997, Pages 272-277

  Rickels, Karl ^a   Schweizer, Edward ^a   Demartinis, Nicholas ^a   Mandos, Laura ^a,b   Mercer, Cheryl ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAL HYDRATE; DIAZEPAM; GEPIRONE; PLACEBO;

ADULT; AGED; ANXIETY NEUROSIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; FATIGUE; FEMALE; HAMILTON SCALE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VERTIGO;

ADULT; ANTI-ANXIETY AGENTS; ANXIETY; DIAZEPAM; DOUBLE-BLIND METHOD; HUMANS; PSYCHIATRIC STATUS RATING SCALES; PYRIMIDINES; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0030860740     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-199708000-00006     Document Type: Article

References (18)

1. Eison MS, Yevich JP, Farney RF. Gepirone hydrochloride. Drugs of the future. J Clin Psychopharmacol 1985;10:456-7.
2. Eison MS, Taylor DP, Riblet LA, New JS, Temple DL Jr. A potential nonbenzodiazepine anxiolytic [abstract]. Neurosci Abstr 1982;8:470.
3. Eison AS, Eison MS, Riblet LA, Temple DL Jr. Indications of serotonergic involvement in the actions of a potential nonbenzodiazepine anxiolytic [abstract]. Neurosci Abstr 1983;9:436.
4. 2 receptor sensitivity after continuous gepirone treatment. Eur J Pharmacol 1985;111:389-92.
5. Csanalosi I, Schweizer E, Case WG, Rickels K. Gepirone in anxiety: a pilot study. J Clin Psychopharmacol 1987;7:31-3.
6. Amsterdam JD, Berwish N, Potter L, Rickels K. Open trial of gepirone in the treatment of major depressive disorder. Curr Ther Res 1987;41:185-93.
7. McGrath PJ, Stewart JW, Quitkin FM, Wager S, Jenkins SW, Archibald DG, Stringfellow JC, Robinson DS. Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. J Clin Psychopharmacol 1994;14:347-52.
8. Hamilton M. The assessment of anxiety by rating. Br J Med Psychol 1959;32:50-5.
9. Guy W. ECDEU assessment manual for psychopharmacology. Rockville, MD: National Institute of Mental Health, US Department of Health, Education, and Welfare; Publication ADM 76-338, 1976.
10. Rickels K, Schweizer E, Case WG, Greenblatt DJ. Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation. Arch Gen Psychiatry 1990;47:899-907.
11. Statistical analysis system, version 6. Cary, NC. SAS Institute, Inc., 1990.
12. Rickels K, Hesbacher P, Fisher E, Norstad N. The Private Practice Research Group (PPRG): a working model from psychopharmacology for clinical research in family practice. Clin Pharmacol 1977;17:541-1.
13. Cutler NR, Sramek JJ, Keppel Hesselink JM, Rickels K, Graham E, Krol A, Roeschen J. A double-blind placebo-controlled study comparing the efficacy and safety of ipsapirone versus lorazepam in patients with generalized anxiety disorder: a prospective multicenter trial. J Clin Psychopharmacol 1993; 13:429-37.
14. Rickels K, Derivan A, Kunz N, Pallay A, Schweizer E. Zalospirone in major depression. A placebo-controlled multicenter study. J Clin Psychopharmacol 1996;16:212-7.
15. Rickels K, Wiseman K, Norstad N, Singer M, Stoltz D, Brown A, Danton J. Buspirone and diazepam in anxiety: a controlled study. J Clin Psychiatry 1982;43:81-6.
16. Rickels K, Schweizer E, Csanalosi I, Case WG, Chung H. Long-term treatment of anxiety and risk of withdrawal: prospective comparison of clorazepate and buspirone. Arch Gen Psychiatry 1988;45:444-50.
17. Kahn RJ, McNair DM, Lipman RS, Covi L, Rickels K, Downing R, Fisher S, Frankenthaler LM. Imipramine and chlordiazepoxide in depressive and anxiety disorders. II. Efficacy in anxious outpatients. Arch Gen Psychiatry 1986;43:79-85.
18. Rickels K, Downing R, Schweizer E, Hassman H. Antidepressants for the treatment of generalized anxiety disorder a placebo-controlled comparison of imipramine, trazodone and diazepam. Arch Gen Psychiatry 1993;50:884-95.