Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity

Toxicology

Volumn 123, Issue 3, 1997, Pages 185-195

  Neuhaus Steinmetz, Ulrich ^a   Rensing, Ludger ^a  

^a UNIVERSITY OF BREMEN   (Germany)

Author keywords

C6 rat glioma; Cytotoxicity; Heat shock protein; Induction; Lipophilicity; Protein denaturation

Indexed keywords

2 PROPANOL; ACETYLSALICYLIC ACID; ALCOHOL; BUTANOL; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; DIETHYLSTILBESTROL; HEAT SHOCK PROTEIN; METHANOL; PARACETAMOL; PHENOL; PHENOL DERIVATIVE; PROPANOL; ROTENONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GLIOMA CELL; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN SYNTHESIS; RAT;

ACTINS; ANIMALS; AUTORADIOGRAPHY; BLOTTING, WESTERN; CELL SURVIVAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLIOMA; HEAT-SHOCK PROTEINS; LIPID METABOLISM; PHARMACEUTICAL PREPARATIONS; PROTEIN DENATURATION; RATS; TUMOR CELLS, CULTURED;

EID: 0030860505     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)00124-8     Document Type: Article

References (28)

1. Alexandrescu A.T., Ng Y.-L., Dobson C.M. Characterization of a TFE-induced partially folded state of α-lactalbumin. J. Mol. Biol. 235:1994;587-599.
2. Arakawa T., Godedette D. The mechanism of helical transition of proteins by organic solvents. Arch. Biochem. Biophys. 240:1985;21-32.
3. Babich H., Borenfreund E. Structure-activity relationship (SAR): models established in vitro with the neutral red cytotoxicity assay. Toxicol. In Vitro. 1:1987;3-9.
4. Bredan P.G.C., Khalawan S.A. Alcohols lower the threshold temperature for the maximal activation of a heat shock expression vector in the yeast Saccharomyces cerevisiae. Microbiol. 140:1994;2225-2228.
5. Dearden, J.C., 1990. Molecular structure and drug transport. In: Hansch, C., Sammes, P.G., Taylor, J.B., Ramsden, C.A. (Eds.), Comprehensive Medicinal Chemistry, vol. 4. Pergamon Press, Oxford, pp. 375-412.
6. 50 tests in rodents. Altern. Lab. Anim. 17:1989;83-100.
7. Gröpper T., Rensing L. Inhibitors of proteases and other stressors induce low-molecular weight heat shock-proteins in Saccharomyces cerevisiae. Exp. Mycol. 17:1993;46-54.
8. Gutknecht J., Tosteson D.C. Ionic permeability of thin lipid membranes. Effects of n-alkyl alcohols, polyvalent cations and a secondary amine. J. Gen. Microbiol. 137:1970;1701-1708.
9. Hahn G.M., Shiu E.C., West B., Goldstein L., Li G. Mechanistic implications of the induction of thermotolerance in Chinese hamster cells by organic solvents. Cancer Res. 45:1985;4138-4143.
10. Hansch, C., Leo, A., 1979. Substituent Constants for Correlation Analysis in Chemistry and Biology. Wiley Interscience, New York.
11. Herskovits T.T., Gadegbeku B., Jaillet H. On the structural stability and solvent denaturation of proteins. J. Biol. Chem. 245:1970;2588-2598.
12. Jurivich D.A., Sistonen L., Sarge K.D., Morimoto R.I. Arachidonate is a potent modulator of human heat shock gene transcription. Proc. Natl. Acad. Sci. USA. 91:1994;2280-2284.
13. + exchange and metabolism. Am. J. Physiol. 259:1990;C727-C737.
14. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
15. Lipnick R.L. Narcosis, electrophile and proelectrophile toxicity mechanisms: application of SAR and QSAR. Environ. Tox. Chem. 8:1989;1-12.
16. Meyer U., Schweim P., Fracella F., Rensing L. Close correlation between heat shock response and cytotoxicity in Neurospora crassa treated with aliphatic alcohols and phenols. Appl. Environ. Microbiol. 61:1995;979-984.
17. Mosser D.D., Kotzbauer P.T., Sarge K.D., Morimoto R.I. In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proc. Natl. Acad. Sci. USA. 87:1990;3748-3752.
18. Mosser D.D., Duchaine J., Massie B. The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by HSP 70. Mol. Cell Biol. 13:1993;5427-5438.
19. Neuhaus-Steinmetz U., Xu C., Fracella F., Oberheitmann B., Richter-Landsberg C., Rensing L. Heat shock response and cytotoxicity in rat glioma cells. Structure-activity relationship of different alcohols. Mol. Pharmacol. 45:1994;36-41.
20. Neuhaus-Steinmetz U., Skrandies S., Rensing L. Heat shock protein synthesis is affected by intracellular pH: inhibition by monensin-induced alkalosis in C6 rat glioma cells. Brain Res. 724:1996;16-24.
21. Nguyen V.T., Morange M., Bensaude O. Protein denaturation during heat shock and related stress. J. Biol. Chem. 264:1989;10487-10492.
22. Nover, L., 1991. Heat Shock Response. CRC Press, Boca Raton, FL.
23. Ritossa F.M. A new puffing pattern induced by a temperature shock and DNP in Drosophila. Experientia. 18:1962;571-573.
24. Skrandies S., Bremer B., Pilatus U., Meyer A., Neuhaus-Steinmetz U., Rensing L. Heat shock- and ethanol-induced ionic changes in C6 rat glioma cells determined by NMR and fluorescence spectroscopy. Brain Res. 746:1997;220-230.
25. +-ATPase regulation by ethanol and noradrenergic manipulations in vivo. In: Rubin, E. (Ed.), Alcohol and the Cell. The New York Academy of Sciences, New York, pp. 401-402.
26. Thomas P.D., Dill K.A. Local and nonlocal interaction in globular proteins and mechanisms of alcohol denaturation. Protein Sci. 2:1993;2050-2065.
27. Towbin H., Staehelin T.M., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
28. Wu, C., Clos, J., Giorgi, G., Haroun, R.I., Kim, S.-J., Rabindran, S.K., Westwood, J.T., Wisniewski, J., Yin, G., 1994. Structure and regulation of heat shock transcription factor. In: Morimoto, R.I., Tissieres, A., Georgopoulos, C. (Eds.), The Biology of Heat Shock Proteins and Molecular Chaperones. Monograph 26, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 395-416.