A new hydroxyl radical scavenger 'EPC' on cadaver heart transplantation in a canine model

Surgery Today

Volumn 27, Issue 10, 1997, Pages 930-935

  Hisamochi, Kunikazu ^a   Morimoto, Toru ^a   Bando, Ko ^a   Senoo, Yoshimasa ^a   Teramoto, Shigeru ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Cadaver heart transplantation; EPC; Radical scavenger

Indexed keywords

ASCORBIC ACID 2 [3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2 (4,8,12 TRIMETHYLTRIDECYL) 2H 1 BENZOPYRAN 6 YL HYDROGEN PHOSPHATE] POTASSIUM; DOPAMINE; SCAVENGER;

ANIMAL TISSUE; ARTICLE; CADAVER DONOR; CONTROLLED STUDY; DOG; DRUG EFFICACY; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART TRANSPLANTATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; REPERFUSION INJURY;

ANIMALS; CADAVER; CARDIOPULMONARY BYPASS; DOGS; FREE RADICAL SCAVENGERS; HEART ARREST, INDUCED; HEART TRANSPLANTATION; HEMODYNAMIC PROCESSES; HYDROXYL RADICAL; MYOCARDIAL REPERFUSION INJURY; PHOSPHORYLCHOLINE;

EID: 0030860342     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02388141     Document Type: Article

References (26)

1. Morimoto T, Hisamochi K, Teramoto S (1993) Transplantation of the canine cadaver heart using core-cooling technique. Acta Med Okayama 47:199-207
2. Stewart JR, Gerhart EB, Wehr CJ, Shuman T, Merrill WH, Hammon JW Jr, Bemder HW Jr (1986) Free radical scavenger and myocardial preservation during transplantation. Ann Thorac Surg 42:390-393
3. Jugman MG, Schemers HG, Dammenhayn L, Haverrish A (1988) Oxygen-derived free radical scavengers for amelioration of reperfusion damage in heart transplantation. J Thorac Cardiovasc Surg 95:368-373
4. Bando K, Teramoto S, Tago M, Seno S, Murakami T, Nawa S, Senoo S (1988) Oxygenated perfluorocarbon, recombinant human superoxide dismutase, and catalase ameliorate free radical induced myocardial injury during heqart preservation and transplantation. J Thorac Cardiovasc Surg 96: 930-938
5. Ding M, Dyke CM, Abd-Elfattah AS, Lehman JD, Dignan R, Wechsler AS (1992) Efficacy of a hydroxyl radical scavenger (VF233) in preventing reperfusion injury in isolated rabbit heart. Ann Thorac Surg 53:1091-1095
6. Ogata K, Yamamoto K, Tsuruoka H (1990) Chemical structure and physicochemical properties of L-ascorbic acid 2-(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran- 6-yl hydrogen) potassium salt (EPC-K1), Iyakuhin Kenkyu (Medical Drugs Research) 21:222-228
7. Mori A, Edamatsu R, Kohno M, Ohmori S (1989) A new hydroxyl radical scavenger:EPC-K1 Neurosciences 48:371-376
8. Herbert CP, Okumura A, Mochizuki M (1989) Immunopharmacological analysis of endotoxin-induced uveitis in the rat. Exp Eye Res 48:693-705
9. Baan J, van de Velde ET, de Bruin HG, Smeenk GJ, Koops J, van Duk AD, Temmerman D, Senden J, Buis B (1984) Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation 70:812-823
10. Burkhoff D, van de Velde ET, Kass D, Baan J, Maughan WL, Sagawa K (1985) Accuracy of volume measurement by conductance catheter in isolated, ejecting canine hearts. Circulation 72:440-447
11. Suga H, Sagawa K, Shoukas AA (1973) Load independence of instantaneous pressure-volume ratio of the canien left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 32:314-322
12. Suga H, Sagawa K (1974) Instantaneous pressure-volume relationships and their ratio in the excised supported canine left ventricle. Circ Res 35:117-126
13. Novitzky D, Wimcomb WN, Cooper DKC, Rose AG, Fraser RC and Bernard CN (1984) Electrocardiographic, hemodynamic, and endocrine changes occuring during experimental brain death in the checma baboon. J Heart Transplant 4:63-69
14. Novitzky D, Wimcomb WN, Cooper DKC, Rose AG, Reichart B (1986) Prevention of myocardial injury during brain death by total cardiac sympathectomy in the chacma baboon. Ann Thoras Surg 41:520-524
15. Gundry SR, de Begona JA, Kawauchi M, Baily LL (1992) Successful transplantation of hearts harvested 30 minutes after death from exsanguination. Ann Thorac Surg 53:772-775
16. Shirakura R, Hirose H, Matsuda H, Nakano S, Nakata S, Ohtani M, Kawaguchi A, Miyagawa S, Takami H, Naka Y, Kawashima Y (1989) Resuscitation and preservation of agonally arrested hearts for transplantation: A study of 24 hours stored canine hearts. Transplant Proc 21:1347-1349
17. Shirakura R, Matsuda H, Nakano S, Nakata S, Kaneko M, Kawaguchi A, Miyamoto Y, Matsuwaka R, Kitagawa S, Fukushima N, Kawashima Y (1991) 24-hour storage for asphyxiated canine hearts with use of Belzer University Wisconsin solution. Transplant Proc 23:662-663
18. Shirakura R, Matsuda H, Nakano S, Nakata S, Kaneko M, Miyamoto Y, Matsukawa R, Kitagawa S, Fukushima N, Kawashima Y (1992) Cardiac function and myocardial performance of 24-hour-preserved asphyxiated canine hearts. Ann Thorac Surg 53:440-444
19. Takagaki M, Hisamochi K, Moromoto T, Bando K, Sano S, Shimizu N (1995) Successful transplantation of cadaver heart harvested one hour after hypoxic cardiac arrest. J Heart Lung Transplant 14:S75 (Suppl. 1 pt. 2 abstract No. 159)
20. Kazuya T, Hoshida S, Kim Y, Nishida M, Fujii H, Kitabatake A, Tada M, Kamada T (1990) Detection of oxygen-derived free radical generation in the canine postischemic heart during late phase of perfusion. Circ Res 66:1160-1165
21. Garlic PB, Davies MJ, Hearse DJ, Slater TF (1987) Direct detection of free radicals in reperfused cat heart using electron spin resonance spectroscopy. Circ Res 61:757-760
22. Myers ML, Bolli R, Lekich RF, Hartley CJ, Roberts R (1985) Enhancement of recovery of myocardial function by oxygen free radical scavenger after reversible regional ischemia. Circulation 72:915-921
23. Przyklenk K, Kloner RA (1986) Superoxide dismutase plus catalase improve contractile function in the canine model the "stunned myocardium". Circ Res 58:148-156
24. Tanemoto K, Sakagami K, Orita K (1993) Beneficial effect of EPC-K1 on the survival of warm ischemic damaged graft in rat cardiac transplantation. Acta Med Okayama 47:121-127
25. Kita T (1992) The effect of EPC on warm ischemia-reperfusion injury in lung tarnsplantation (in Japanese with English abstract). Ishoku (Jpn J Transplant) 27:15-25
26. Flaherry J, Pitt B, Gruber J, Heuser R, Rothbaum D, Burwell L, George B, Kereiakes D, Deitchman D, Gustafson N, Brinker J, Becker L, Mancini J, Topol E, Werns S (1994) Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 89:1982-1991