Comparison of the effects of different low molecular weight heparins on the hemostatic system activation in vivo in man

Thrombosis and Haemostasis

Volumn 78, Issue 2, 1997, Pages 876-879

  Wolzt, Michael ^a,b   Eder, Michaela ^a   Weltermann, Ansgar ^a   Entlicher, Jesusa ^a   Eichler, Hans Georg ^a   Kyrle, Paul A ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; BETA THROMBOGLOBULIN; CERTOPARIN; DALTEPARIN; ENOXAPARIN; LOW MOLECULAR WEIGHT HEPARIN; PROTHROMBIN; THROMBIN;

ADULT; ARTICLE; BLOOD CLOTTING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HEMOSTASIS; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; VENOUS BLOOD;

EID: 0030859909     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1657645     Document Type: Article

References (27)

1. Hull RD, Raskob GE, Pineo GF, Green D, Trowbridge AA, Elliott CG, Lemer GR, Hall J, Sparling T, Brettell HR, Norton J, Carter CJ, George R, Merle G, Ward J, Mayo W, Rosenbloom D, Brant R. Subcutanous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal vein thrombosis. N Engl J Med 1992; 326: 975-82.
2. Imperiale TF, Speroff T. A meta-analysis of methods to prevent venous thromboembolism following total hip replacement. JAMA 1994; 271: 1780-5.
3. Kakkar VV. Effectiveness and safety of low molecular weight heparins (LMWH) in the prevention of venous thromboembolism (VTE). Thromb Haemost 1995; 74: 364-8.
4. Leizorovicz A, Simonneau G, Decousus H, Boissel JP. Comparison of efficacy and safety of low molecular weight heparins and unfractionated heparin in initial treatment of deep venous thrombosis: a meta-analysis. BMJ 1994; 309: 299-304.
5. Lensing AW, Prins MH, Davidson BL, Hirsh J. Treatment of deep venous thrombosis with low-molecular-weight heparins. A meta-analysis. Arch Intern Med 1995; 155: 601-7.
6. Prandoni P, Lensing AW, Büller HR, Carta M, Cogo A, Vigo M, Casara D, Ruol A, ten Cate JW. Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis. Lancet 1992; 339: 441-5.
7. Gurfinkel EP, Manos EJ, Mejail RI, Cerda MA, Duronto EA, Garcia CN, Daroca AM, Mautner B. Low molecular weight heparin versus regular heparin or aspirin in the treatment of unstable angina and silent ischemia. J Am Coll Cardiol 1995; 26: 313-8.
8. Fragmin during instability in coronary artery disease (FRISC) study group. Low-molecular-weight heparin during instability in coronary artery disease. Lancet 1996; 347: 561-8.
9. Cohen M, Demers C, Gurfinkel E, Fromell G, Langer A, Turpie AGG, ESSENCE Group. Primary end point analysis from the ESSENCE trial: Enoxaparin vs unfractionated heparin in unstable angina and non-Q wave infarction. Circulation 1996; 94: I-554.
10. Meyer G, Brenot F, Pacouret G, Simonneau G, Gillet Juvin K, Charbonnier B, Sors H. Subcutaneous low-molecular-weight heparin Fragmin versus intravenous unfractionated heparin in the treatment of acute non massive pulmonary embolism: an open randomized pilot study. Thromb Haemost 1995; 74: 1432-5.
11. Collignon F, Frydman A, Caplain H, Ozoux ML, Le Roux Y, Bouthier J, Thébault JJ. Comparison of the pharmacokinetic profiles of three low molecular mass heparins - dalteparin, enoxaparin and nadroparin - administered subcutaneously in healthy volunteers (doses for prevention of thromboembolism). Thromb Haemost 1995; 73: 630-40.
12. Azizi M, Veyssier-Belot C, Alhenc-Gelas M, Chatellier G, Billaud-Mesguish E, Fiessinger JN, Aiach M. Comparison of biological activities of two low molecular weight heparins in 10 healthy volunteers. Br J Clin Pharmacol 1995; 40: 577-84.
13. Eriksson BI, Söderberg K, Widlund L, Wandeli B, Tengborn L, Risberg B. A Comparative Study of three low-molecular weight heparins (LMWH) and unfractionated heparin (UFH) in healthy volunteers. Thromb Haemost 1995; 73: 398-401.
14. Stiekema JCJ, Van Griensven JMT, Van Dinther TG, Cohen AF. A cross-over comparison of the anti-clotting effects of three low molecular weight heparins and glycosaminoglucuronan. Br J Clin Pharmacol 1993; 36: 51-6.
15. 1α in humans in response to a standardized vascular injury and the influence of aspirin. Circulation 1989; 79: 29-38.
16. Gresele P, Arnout J, Deckmyn H, Huybrechts E, Pieters G, Vermylen J. Role of proaggregatory and antiaggregatory prostaglandins in hemostasis - studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism. J Clin Invest 1987; 80: 1435-45.
17. Kyrle PA, Eichler HG, Jäger U, Lechner K. Inhibition of prostacyclin and thromboxane A, generation by low-dose aspirin at the site of plug formation in man in vivo. Circulation 1987a; 75: 1025-9.
18. Kyrle PA, Westwick J, Scully MF, Kakkar VV, Lewis GP. Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man - effect of low-dose aspirin. Thromb Haemostas 1987b; 57: 62-6.
19. Nowak J, Fitzgerald GA. Redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in man. J Clin Invest 1989; 83: 380-5.
20. Weiss HJ, Lages B. Evidence for tissue factor-dependent activation of the classic intrinsic coagulation mechanism in blood obtained from bleeding time wounds. Blood 1988; 71: 629-35.
21. Mielke CH, Kaneshiro MM, Mahler IA, Weiner J, Rapaport SI. The standardized Ivy bleeding time and its prolongation by aspirin. Blood 1969; 34: 204-15.
22. Bauer KA. Laboratory markers of coagulation activation. Arch Pathol Lab Med 1993; 117: 71-7.
23. Bendetowicz AV, Kai H, Knebel R, Caplain H, Hemker HC, Lindhout T, Beguin S. The effect of subcutaneous injection of unfractionated and low molecular weight heparin on thrombin generation in platelet rich plasma: A study in human volunteers. Thromb Haemost 1994; 72: 705-12.
24. Wolzt M, Weltermann A, Nieszpaur-Los M, Schneider B, Fassolt A, Lechner K, Eichler HG, Kyrle PA. Studies on the neutralizing effects of protamine on unfractionated and low molecular weight heparin (Fragmin®) at the site of activation of the coagulation system in man. Thromb Haemost 1995; 73: 439-43.
25. Jensen AH, Beguin S, Josso F. Factor V and VIII activation "in vivo" during bleeding. Evidence of thrombin formation at the early stage of hemostasis. Pathol Biol Paris 1976; 24 (Suppl): 6-10.
26. Eichinger S, Wolzt M, Nieszpaur-Los M, Schneider B, Lechner K, Eichler HG, Kyrle PA. Effects of a low molecular weight heparin (Fragmin®) and of unfractionated heparin on coagulation and platelet activation at the site of plug formation in vivo. Thromb Haemost 1994; 72: 831-5.
27. Eichinger S, Wolzt M, Nieszpaur-Los M, Schneider B, Heinrichs H, Lechner K, Eichler HG, Kyrle PA. Effects of r-hirudin (HBW 023). low molecular weight heparin (LMWH, Fragmin®) and unfractionated heparin (UFH) on the coagulation system and on platelet activation at the site of plug formation in vivo. Arterioscler Thromb Vase Biol 1995; 15: 886-92.