Glutathione S-transferase θ genetic polymoryhism might influence tacrine hepatotoxtcity in Alzheimer's patients

Pharmacogenetics

Volumn 7, Issue 3, 1997, Pages 251-253

  Becquemont, Laurent ^a   Lecoeur, Sylvaine ^b   Simon, Tabassome ^a   Beaune, Philippe ^b   Funck Brentano, Christian ^a   Jaillon, Patrice ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Genetic polymorphism; Glutathione S transferase ,; Hepatotoxicity; Tacrine

Indexed keywords

AMINOTRANSFERASE; GLUTATHIONE TRANSFERASE; TACRINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LIVER TOXICITY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

AGED; ALANINE TRANSAMINASE; ALZHEIMER DISEASE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; LIVER DISEASES; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS; TACRINE;

EID: 0030859342     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199706000-00011     Document Type: Article

References (8)

1. Arand M, Mühlbauer R, Hengstler J, Jäger E, Fuchs J, Winkler L, Oesch F. A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal Biochem 1996: 236, 184-186.
2. Brockmöller J, Gross D, Kerb R, Drakoulis N, Roots I. Correlation between trans-stibene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class Mu gene detected by polymerase chain reaction. Biochem Pharmacol 1992: 43, 647-650.
3. Green VJ, Pirmohamed M, Kitteringham NR, Knapp MJ, Park BK. Glutathione S-transferase μ genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis. Br J Clin Pharmacol 1995: 39, 411-415.
4. Madden S, Woolf TF, Pool WF, Park BK. An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Biochem Pharmacol 1993: 46, 13-20.
5. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB. Human glutathione N-transferase. Theta (GSTT1): cDNA cloning and the characterisation of a genetic polymorphism.. Biochem J 1994: 300, 271-276.
6. Watkins PB, Zimmerman HJ, Knapp MJ, Gracon SI, Lewis KW. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 1994: 271, 992-998.
7. Warholm M, Rane A, Alexandrie A-K, Monaghan G, Rannung A. Genotypic and phenotypic determination of polymorphic glutathione transferase T1 in a Swedish population. Pharmacogenetics 1995: 5, 252-254.
8. Woolf TF, Pool WF, Bjorge SM, Chang T, Goel OP, Purchase CF, Schroeder MC, Kunze KL, Trager WF. Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparation. Species differences. Drug Metab Dispos 1993: 21, 874-882.