Dietary carrot results in diminished ovarian progesterone secretion, whereas a metabolite, retinoic acid, stimulates progesterone secretion in the in vitro perfused rabbit ovary

Fertility and Sterility

Volumn 68, Issue 2, 1997, Pages 358-363

  Keenan, David L ^a,b   Dharmarajan, Arunasalam M ^a,c   Zacur, Howard A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Southeastern Fertility Institute   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Corpus luteum; Progesterone; Rabbit; Retinoic acid; carotene

Indexed keywords

BETA CAROTENE; CAROTENE; CHORIONIC GONADOTROPIN; PROGESTERONE; PROSTAGLANDIN E2; RETINOIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARROT; CONTROLLED STUDY; CORPUS LUTEUM; DIET; DIET SUPPLEMENTATION; FEMALE; NONHUMAN; OVARY; PRIORITY JOURNAL; PROGESTERONE RELEASE; PSEUDOPREGNANCY; RABBIT; STEROID RELEASE; STEROIDOGENESIS;

EID: 0030859062     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(97)81529-4     Document Type: Article

References (20)

1. Kemmann E, Pasquale SA, Skaf R. Amenorrhea associated with carotenemia. J Am Med Assoc 1983;249:926-9.
2. Page SW. Golden ovaries. Aust N Z J Obstet Gynaecol 1971; 11:32-6.
3. Pops MA, Schwabe AD. Hypercarotenemia in anorexia nervosa. J Am Med Assoc 1968;205:121-2.
4. Frumar AM, Meldrum DR, Judd HL. Hypercarotenemia in hypothalamic amenorrhea. Fertil Steril 1979;32:261-4.
5. Talavera F, Chew BP. Comparative role of retinol, retinoic acid and β-carotene on progesterone secretion by pig corpus luteum in vitro. J Reprod Fertil 1988;82:611-5.
6. Juneja HS, Murthy SK, Ganguly J. The effect of vitamin A deficiency on the biosynthesis of steroid hormones in rats. Biochem J 1966:99:138-45.
7. Bagavandoss P, Midgley AR. Lack of difference between retinoic acid and retinol in stimulating progesterone production by luteinizing granulosa cells in vitro. Endocrinology 1987; 121:420-8.
8. Bagavandoss P, Midgley AR. Biphasic action of retinoids on gonadotropin receptor induction in rat granulosa cells in vitro. Life Sci 1988;43:1607-14.
9. Schweigert FJ, Zucker H. Concentrations of vitamin A, β-carotene and vitamin E in individual bovine follicles of different quality. J Reprod Fertil 1988;82:575-9.
10. Folman Y, Ascarelli I, Kraus D, Barash H. Adverse effect of β-carotene in diet on fertility of dairy cows. J Dairy Sci 1987; 70:357-66.
11. Dharmarajan AM, Yoshimura Y, Sueoka K, Atlas SJ, Dubin NH, Ewing LL, et al. Progesterone secretion by corpora lutea of the isolated perfused rabbit ovary during pseudopregnancy. Biol Reprod 1988;38:1137-43.
12. Sporn MB, Roberts AB, Goodwin DS, editors. The retinoids. New York: Raven Press, 1994:229-55, 319-44, 455-6.
13. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988;240:889-95.
14. 3 signalling. Nature 1992;355:446-9.
15. Keyes PL, Armstrong DT. Endocrine role of follicles in the regulation of corpus luteum function in the rabbit. Endocrinology 1968;83:509-15.
16. Holt JA, Keyes PL, Brown JM, Miller JB. Premature regression of corpora lutea in pseudopregnant rabbits following the removal of polydimethylsiloxane capsules containing 17β-estradiol. Endocrinology 1975;97:76-82.
17. Lee C, Keyes PL, Jacobson HI. Estrogen receptor in the rabbit corpus luteum. Science 1971; 173:1032-3.
18. Ganguly J, Pope GS, Thompson SY, Toothill J, Edwards-Webb JD, Waynforth HB. Studies on the metabolism of vitamin A: the effect of vitamin A status on the content of some steroids in the ovaries of pregnant rats. Biochem J 1971; 123:669-70.
19. Folman Y, Russell RM, Tang GW, Wolf G. Rabbits fed on β-carotene have higher serum levels of all-transretinoic acid than those receiving no β-carotene. Br J Nutr 1989;62:195-201.
20. Dharmarajan AM, Mastroyannis C, Yoshimura Y, Atlas SJ, Wallach EE, Zirkin BR. Quantitative light microscopic analysis of corpus luteum growth during pseudopregnancy in the rabbit. Biol Reprod 1988;38:863-70.