Adenosine depresses transmitter release but is not the basis for 'tetanic fade' at the neuromuscular junction of the rat

Neuroscience Letters

Volumn 230, Issue 2, 1997, Pages 81-84

  Malinowski, Mark N ^a   Cannady, Steven B ^a   Schmit, Kenneth V ^a   Barr, Paul M ^a   Schrock, Jon W ^a   Wilson, David F ^a  

^a MIAMI UNIVERSITY   (United States)

Author keywords

Adenosine A1 receptor; End plate potential; Neuromodulation; P1 purinoceptors; Presynaptic receptors

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; PRESYNAPTIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; INTRACELLULAR RECORDING; MINIATURE ENDPLATE POTENTIAL; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE; ANIMALS; DIAPHRAGM; ELECTRIC STIMULATION; FEEDBACK; FEMALE; MOTOR ENDPLATE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NEUROMUSCULAR JUNCTION; PHRENIC NERVE; RATS; RECEPTORS, PURINERGIC P1; THEOPHYLLINE; XANTHINES;

EID: 0030858513     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00480-1     Document Type: Article

References (18)

1. 1 receptors in rat striatal glutamatergic nerve terminals, Neurosci. Lett., 220 (1996) 163-166.
2. Arlinghaus, L. and Lee, K.S., Endogenous adenosine mediates the sustained inhibition of excitatory synaptic transmission during moderate hypoxia, Brain Res., 724 (1996) 265-268.
3. Betz, W.J., Depression of transmitter release at the neuromuscular junction of the frog, J. Physiol. (Lond.), 206 (1970) 629-644.
4. 2a-facilitory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm, J. Neurophysiol., 76 (1996) 3910-3919.
5. Debanne, D., Guerineau, N.C., Gahwiler, B.H. and Thompson, S.M., Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release, J. Physiol. (Lond.), 491 (1996) 163-176.
6. Hamilton, B.R. and Smith, D.O., Autoreceptor-mediated purinergic and cholinergic inhibition of motor nerve terminal calcium currents in the rat, J. Physiol. (Lond.), 432 (1991) 327-341.
7. Hamilton, B.R. and Smith, D.O., Calcium currents in rat motor nerve terminals, Brain Res., 584 (1992) 123-131.
8. Hubbard, J.I. and Wilson, D.F., Neuromuscular transmission in the mammalian preparation in the absence of blocking drugs and the effect of D-tubocurarine, J. Physiol. (Lond.), 228 (1973) 307-325.
9. Ji, Z. and Liu, C., Presynaptic nature of the initial rundown of tetanic train of endplate potentials in isolated non-uniform stretched muscle preparation of rats, Chin. J. Pharmacol. Toxicol., 7 (1993) 1-5.
10. Nagy, J., Baker, M., Morris, P. and Whittaker, L., The preparation and characterization of synaptic vesicles of high purity, Brain Res., 109 (1976) 285-309.
11. Redman, R.S. and Silinsky, E.M., ATP released together with acetylcholine as the mediator of neuromuscular depression at frog motor nerve endings, J. Physiol. (Lond.), 477 (1994) 117-127.
12. Road, J., Osborne, S. and Cairns, A., Phrenic motoneuron firing rates during brief inspiratory resistive loads, J. Appl. Physiol., 79 (1995) 1540-1545.
13. Silinsky, E.M., On the association between secretion and the release of adenosine nucleotides from mammalian motor nerve terminals, J. Physiol. (Lond.), 247 (1975) 145-162.
14. Silinsky, E.M., Evidence for specific adenosine receptors at cholinergic nerve endings, Br. J. Pharmacol., 71 (1980) 191-194.
15. Silinsky, E.M., The influence of 2-chloroadenosine on potassium evoked and neurally-evoked acetylcholine secretion from normal or latent active zones in the frog, Br. J. Pharmacol., 93 (1988) 833-838.
16. Silinsky, E.M. and Hubbard, J.I., Release of ATP from rat motor nerve terminals, Nature, 243 (1973) 404-405.
17. Wilson, D.F., Depression, facilitation, and mobilization of transmitter at the rat diaphragm neuromuscular junction, Am. J. Physiol., 237 (1979) C31-C37.
18. Wilson, D.F., Influence of presynaptic receptors on neuromuscular transmission in the rat, Am. J. Physiol., 242 (1982) 366-373.