Clinical neurosciences in the decade of the brain: Hypotheses in neuro- oncology: VEG/PG acts upon the actin cytoskeleton and is inhibited by dexamethasone: Relevance to tumor angiogenesis and vasogenic edema

Yale Journal of Biology and Medicine

Volumn 69, Issue 4, 1997, Pages 337-355

  Criscuolo, Gregory R ^a,b   Balledux, Jeroen P ^a  

^a YALE UNIVERSITY   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULOTROPIN; CALCIUM; DRUG DERIVATIVE; ENDOTHELIAL CELL GROWTH FACTOR; FLUORESCENT DYE; GLUCOCORTICOID; LYMPHOKINE; PHALLOIDIN; RHODAMINE; VASCULOTROPIN A;

ACTIN FILAMENT; ANGIOGENESIS; ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; BRAIN EDEMA; BRAIN TUMOR; CELL KINETICS; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; PATHOPHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FEMALE; FLUORESCENCE MICROSCOPY; LEWIS RAT; METABOLISM; ULTRASTRUCTURE; VASCULARIZATION;

ANIMALS; BRAIN NEOPLASMS; CALCIUM; CELLS, CULTURED; CYTOSKELETON; DEXAMETHASONE; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCENT DYES; GLUCOCORTICOIDS; HUMANS; LYMPHOKINES; MICROSCOPY, FLUORESCENCE; PHALLOIDINE; RATS; RATS, INBRED LEW; RHODAMINES; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0030858318     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Black, K.L. and Hoff, J.T. Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats. Ann. Neurol. 18:349-351, 1985.
2. Blackwell, G.J., Carnuccio, R., Di Rosa, M., Flower R.J., Parente, L., and Persico, P. Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature 287:147-149, 1980.
3. Chan, P.H. and Fishman, R.A. The role of arachidonic acid in vasogenic braín edema. Feder. Proc. 43:210-213, 1984.
4. Liddell, R.H., Scott, A.R.W., and Simpson, G.J. Histamine-induced changes in the endothelium of post-capillary venules: effects of chelating agents and cytochalasin B. Bibl. Anat. 20:109-112, 1981.
5. Stein-Werblowsky, R. A permeability-enhancing factor produced by tumor. The genesis of malignant effusions. J Cancer Res. Clin. Oncol. 97:315-320, 1980
6. Unterberg, A. and Baethmann, A.J, The kallikrein-kinin system as a mediator of vasogenic brain edema. Part 1: Cerebral exposure to bradykinin and plasma. J. Neurosurg. 61:87-96, 1984.
7. Berkman, R.A., Merrill, M.J., Reinhold, W.C., Monacci, W.T., Saxena, A., Clark, W.C., Robertson, J.T., Ali, I.U., and Oldfield, E.H. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest. 91:153-159, 1993.
8. Breier, G., Albrecht, U., Sterrer, S., and Risau, W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114:521-32, 1992
9. Brown, L.F., Berse, B., Jackman, R.W., Tognazzi, K., Manseau, E.J., Dvorak, H.F., Senger, D.R. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Path. 143:1255-1262, 1993.
10. Brown, L.F., Berse, B., Jackman, R.W., Tognazzi, K., Manseau, E.J., Dvorak, H.F., Senger, D.R. Expression of vascular permeability factor (vascular endothelial growth factor and it's receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res. 53:4727-4735, 1993.
11. Bruce, J.N., Criscuolo, G.R., Merrill, M.J., Moquin, R.R., Blacklock, J.B., Oldfield, E.H. Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone. J. Neurosurg. 67:880-884, 1987.
12. Chamock-Jones, D.S., Sharkey, A.M., Rajput-Williams, J., Burch, D., Schofield, J.P., Fountain, S.A., Boocock, CA., and Smith, S.K. Identification and localization of alternatively spliced rnRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol. Reproduct. 48:1120-1128, 1993.
13. Collins, P.D., Connolly, D.T., and Williams, T.J. Characterization of the increase in vascular permeability induced by vascular permeability factor in vivo. British J Phar 109:195-199, 1993.
14. Criscuolo, G.R. Possible relationship between vascular permeability factors, endothelial cells and peritumoral brain edema. In Simionescu, N. and Simionescu, M., eds. Endothelial Cell Dysfunctions. New York: Plenum Press; 1992, pp 477-493.
15. Criscuolo, G.R. The genesis of peritumoral vasogenic brain edema and tumor cysts: A hypothetical role for tumor-derived vascular permeability factor. Yale J. Biol. Med. 66:277-314, 1993.
16. Criscuolo, G.R., Lelkes, P.I., Rotrosen, D., and Oldfield, E.H. Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity. J. Neurosurg. 71:884-891, 1989.
17. Criscuolo, G.R., Merrill, M.J., Oldfield, E.H. Characterization of a protein product of human malignant glial tumors that induces microvascular permeability. Adv. Neurol. 52:469-474, 1990.
18. Criscuolo, G.R., Merrill, M.J., and Oldfield, E.H. Further characterization of malignant-glioma derived vascular permeability factor. J. Neurosurg. 69:254-262, 1988.
19. Dvorak, H.F Tumors: Wounds that do not heal. N. Eng. J. Med. 315:1650-1659, 1986.
20. Dvorak, H.F, Sioussat, T.M., Brown, L.F., Berse, B., Nagy, J.A., Sotrel, A., Manseau, E.J., Van De Water, L., and Senger, D.R. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med. 174:1275-1278, 1991.
21. Myoken ,Y., Kayada, Y., Okamoto, T., Kan, M., Sato, G.H., and Sato, J.D. Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites. Proc. Nat. Acad. Sci. USA. 88:5819-5823, 1991.
22. Park, J.E., Keller, G.A., and Ferrara, N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4. 12:1317-1326, 1993.
23. Plate, K.H., Breier, G., Millauer, B., Ullrich, A., and Risau, W. Upregulation of Vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 53:5822-5827, 1993.
24. Rotrosen, D. and Gallin, J.I. Histamine type 1 receptor occupancy increases endothelial cytosolic calcium, reduces F-actin and promotes albumin diffusion across cultured endothelial monolayers. J. Cell Bioch. 103:2379-2387, 1986.
25. Senger, D.R., Galli, Dvorak, A.M., Peruzzi, C.A., Harvey, VS., and Dvorak, H.F. Tbmor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219:983-985, 1983.
26. Senger, D.R., Peruzzi, C.A., Feder, J., and Dvorak, H.F. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 46:5629-5632, 1986.
27. Shifren, J.L., Doldi, N., Ferrara, N., Mesiano, S., Jaffe, R.B. In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action. J. Clin. Endocrin. Metab. 79:316-322, 1994.
28. Strugar, J., Rothbart, D., Harrington, W., Criscuolo, G.R. Vascular permeability factor in brain metastases: correlation with vasogenic brain edema and tumor angiogenesis. J. Neurosurg. 81:560-566, 1994.
29. Strugar, J., Criscuolo, G.R., Rothbart, D., and Harrington, W. Vascular endothelial growth/permeability factor expression in human glioma specimens: correlation with vasogenic brain edema and tumor-associated cysts. J. Neurosurg. 83:108-115, 1995.
30. Takahashi, A., Sasaki, H., Kim, S.J., Tobisu, K., Kakizoe, T., Tsukamoto, T., Kumamoto, T., Sugimura, T., and Terada, M. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placental growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 54:4233-4237, 1994.
31. Bikfalvi, A., Sauzeau, C., Moukadiri, H., Maclouf, J., Busso, N., Bryckaert, M., Plouet, J., and Toblem, G. Interaction of vasculotropin/vascular endothelial growth factor with human umbilical vein endothelial cells: binding, internalization, degradation and biological effects. J. Cell Physiol. 149:50-59, 1991.
32. Brock, T.A., Dvorak, H.F., Senger, D,R. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor in human endothelial cells. Am. J. Pathol. 38:213-221, 1991.
33. Gitay-Goren, H., Soker, S., Vlodavsky, I., and Neufeld, G. The binding of vascular endothelial growth factor to it's receptors is dependant on cell surface-associated heparin-like molecules. J. Biol. Chem. 267:6093-6098, 1992.
34. Rothbart, D., Awad, IA, Lee, J., Kim, J., Harbaugh, R., and Criscuolo, G.R. Expression of angiogenesis factors and structural proteins in central nervous system vascular malformations. Neurosurgery 38:915-925, 1996.
35. Skirgaudas, M., Awad, I.A., Kim, J., Rothbart, D., and Criscuolo, G. Expression of angiogenesis factors and selected vascular wall matrix proteins in tracranial saccular aneurysms. Neurosurgery 36:537-547, 1996.
36. Drenckhahn, D. Cell motility and cytoplasmic filaments in vascular endothelium. Prog. Appl. Microcirc. 1:53-70, 1983.
37. Northover, A.M. and Northover, B.J. Changes in vascular endothelial shape and of membrane potential in response to the ionophore A23187. Int. J. Microcirc. Clin. Exp. 6:137-148, 1987.
38. Ridley, A.J. and Hall, A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399, 1992.
39. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410, 1992.
40. Enomoto, T., Okamoto, T., and Sato, J.D. Vascular endothelial growth factor induces the disorganization of actin stress fibers accompanied by protein tyrosine phosphorylation and morphological change in Balb/C3T3 cells. Biochem. Biophys. Res. Commun. 202:1716-1723, 1994.
41. Fechheimer, M., and Zigmond, S.H. Focusing on unpolymerized actin. J. Cell Biol. 123:1-5, 1991.
42. Hartwig, J.H. and Kwiatkowski, DJ. Actin-binding proteins. Curr. Opin. Cell Biol. 3:87-97, 1991.
43. Matsudaira, P. and Janmey, P. Pieces in the actin severing protein puzzle. Cell 54:139-140, 1988.
44. Abbott, N.J., Hughes, C.C.W., Revest, P.A., and Greenwood, J. Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J. Cell Sci. 103:23-37, 1992.
45. Comair, Y.G., Schipper, H.M., and Brem, S. The prevention of oxyhemoglobin-induced endothelial and smooth muscle cytoskeletal injury by deferoxamine. Neurosurgery 32:58-65, 1993.
46. Hinshaw, D.B., Burger, J.M., Armstrong, B.C., and Hyslop, P.A. Mechanism of endothelial cell shape change in oxidant injury. J. Surg. Res. 46, 339-349, 1989.
47. Shasby, D.M., Shasby, S.S., Sullivan, R., and Peach, M.J. Role of endothelial cell cytoskeleton in control of endothelial permeability. Circ. Res. 51:657-661, 1982.
48. Wysolmerski, R.B. and Lagunoff, D. Inhibition of endothelial cell retraction by ATP depletion. Am. J. Path. 132:28-37, 1988.
49. Brightman, M.W., Klatzo, I., Olsson, Y, and Reese, T.S. The blood-brain barrier to proteins under normal and pathological conditions. J. Neurol. Sci. 10:215-239, 1970.
50. Long, D.M. Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J. Neurosurg. 32:127-144, 1970.
51. Long, D.M. Vascular ultrastructure in human meningiomas and schwannomas. J. Neurosurg. 38:409-419, 1973.
52. Long, D.M. Capillary ultrastructure in human metastatic brain tumors. J. Neurosurg. 51:53-58, 1979.
53. Oldendorf, W.H., Cornford, M.E., and Brown, J.B. The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann. Neurol. 5:409-417, 1977.
54. Balledux, J.P.W., Rothbart, D., and Criscuolo, G.R. VEG/PF actions on the endothelial cytoskeleton. J. Neurooncol. 21:205, 1994. (Abstract).
55. Bucci, C., Parton, R.G., Mather, I.H., Stunnenberg, H., Simons, K., Hoflack, B., and Zerial, M. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70:715-728, 1992.
56. Ferrara, N., King, K.L., Winer, J., and Johnson, R. Early transmembrane signaling events of vascular endohelial growth factor (VEGF) in bovine capillary endothelial cells (BCEC). FASEB J. A904:3106, 1991.
57. Goldschmidt-Clermont, P.J., Furman, M.I., Wachsstock, D., Safer, D., Nachmias, V.T,. and Pollard, T.D.: The control of nucleotide exchange by thymosine ß4 and profilin. A potential regulatory mechanism for actin polymerization in cells. Molec Biol Cell 3:1015-1024, 1992
58. Putney, Jr., J.W. Excitement about calcium signalling in inexcitable cells. Science 262:676-678, 1993.
59. Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C.H. Different signal transduction properties of KDR and Fill: Two receptors for vascular endothelial growth factor. J. Biol. Chem. 43:26988-26995, 1994.
60. Galicien, J.H. and French, L.A. Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery. Am. Pract. 12:169-174, 1961.
61. Gerber, A.M. and Savolaine, E.R. Modification of tumor enhancement and brain edema in computerized tomography by corticosteroids: case report. Neurosurgery 6:282-284, 1980.
62. Hatam, A., Zhao-Ying, Yu., Bergstrom, M., Berggren, B.M., and Greitz, T. Effect of dexamethasone treatement on peritumoral brain edema: Evaluation by computed tomography. J. Comp. Assist. Tomogr. 6:586-592, 1982.
63. Long, D.M., Hartmann, J.F., and French, L.A. The response of human cerebral edema to glucosteroid administration. An electron microscopic study. Neurology 16:521-528, 1966.
64. Yamada, K., Ushio, Y., Hayakawa, T., Kato, A., Yamada, N., and Mogami, H. Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model. J. Neurosurg. 57:394-398, 1982.
65. Yu, Z.Y., Wrange, O., Boethius, J., Hatam, H., Granholm, L., and Gustafsson, J.A. A study of glucocorticoid receptors in intracranial tumors. J. Neurosurg. 55:757-760, 1981.