Modulation of the clastogenic activity of bleomycin by reduced-glutathione, glutathione-ester and buthionine sulphoximine

Mutagenesis

Volumn 12, Issue 4, 1997, Pages 221-225

  Chattopadhyay, A ^a   Choudhury, S ^a   Chatterjee, A ^a  

^a NORTH EASTERN HILL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; BUTHIONINE SULFOXIMINE; CLASTOGEN; DNA; GLUTATHIONE; GLUTATHIONE DERIVATIVE;

ARTICLE; CHROMATID ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; GENE DELETION; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MUTAGENICITY; NORMAL HUMAN; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; BLEOMYCIN; BUTHIONINE SULFOXIMINE; CHROMOSOME ABERRATIONS; GLUTATHIONE; HUMANS; LYMPHOCYTES; MALE; MUTAGENS;

EID: 0030857833     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/12.4.221     Document Type: Article

References (36)

1. Biaglow,J.E., Clark,E.P., Epp,E.R., Morse-Guardio,M., Varnes,M.E. and Mitchell,J.B. (1983) Non-protein thiols and the radiation response AS49 human lung carcinoma cells. Int. J. Radiat. Biol., 44, 489-498.
2. Bornstein,R.S., Hungerford,D.A., Haller,G., Engstrom,P.F. and Varbro,J.W. (1971) Cytogenetic effects of bleomycin therapy in man. Cancer Res., 31, 2004-2007.
3. Bump,E.A., Ning,Y.Y. and Brown,J.M. (1982) Radiosensitization of hypoxic tumour cells by depletion of intracellular glutathione. Science, 217, 544-545.
4. Chatterjee,A. and Jacob-Raman,M. (1988) A comparison of aberration distribution and cell cycle progression in cells treated with bleomycin with those exposed to X-rays. Mutat. Res., 202, 51-57.
5. Chatterjee,A., Jacob-Raman,M. and Mohapatra,B. (1989) Potentiation of bleomycin induced chromosome aberrations by the radioprotector reduced glutathione. Mutat. Res., 214, 207-213.
6. Chatterjee,A. and Jacob-Raman,M. (1993) Protective effect of cysteine against X-ray and bleomycin induced chromosomal aberrations and cell cycle delay. Mutat. Res., 290, 231-238.
7. Clark,E.P. (1986) Thiol induced biochemical modification of chemo and radio responses. Int. J. Radiat. Oncol. Biol. Phys., 12, 1121-1126.
8. Clark,E.P., Biaglow,E.R., Morse-Gaudio,J.E. and Zachgo,E. (1984) Glutathione depletion, radiosensitization and misonidazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine. Radiat. Res., 98, 1370-380.
9. Dethmers,J.K. and Meisten,A. (1981) Glutathione export by human lymphoid (cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation. Proc. Natl. Acad. Sci. USA, 78, 7492-7496.
10. Evans,H.J. (1977) Molecular mechanism in the induction of chromosome aberration. In Scott,D., Bridges,B.A. and Sobels, EH. (eds), Progress in Genetic Toxicology. Elsiever/North Holland, Amsterdam, pp. 57-74.
11. Glover,D., Fox,K.R. Weiler,C., Kligerman,M.M., Turrisi,A. and Glick,J.H. (1988) Clinical trials of WR 2721 prior to alkylating agent in chemotherapy and radiotherapy. Pharmacol. Ther., 39, 3-7.
12. Goto,K., Akematsu,T., Shimagu,H. and Suigiyama,T. (1975) Simple differential Giemsa staining of sister chromatids after treatment with photosensitive dyes and exposure to light and the mechanism of staining. Chromosoma, 53, 223-230.
13. Green,J.A., Vistica,D.T., Young,R.C., Hamilton,T.C., Rogan,A.M. and Ozols,R.F. (1984) Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion. Cancer Res., 44, 5427-5431.
14. Hamilton,T.C., Winker,M.A. and Lowe,K.G. (1985) Augmentation of adriamycin, melphalan and cis-platin cytotoxicity in drug resistance and sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. Biochem. Pharmacol., 34, 2583-2587.
15. Hoffmann,G.R., Colyer,S.P. and Littlefield,L.G. (1993) Induction of micronuclei by bleomycin in Go human lymphocytes: II Potentiation by radioprotectors. Environ. Mol. Mutagenesis, 21, 136-143.
16. Lee,E.Y.F., Allunin-Turner,M.J. and Siemann,D.W. (1987) Depletion of tumour versus normal tissue glutathione by buthionine sulfoximine. Br. J. Cancer, 56, 33-38.
17. Littlefield,L.G. and Hoffmann,G.R. (1993) Modulation of the clastogenic activity of ionizing radiation and bleomycin by the aminothiol WR 1065. Environ. Mol. Mutagenesis, 22, 225-230.
18. Lown,J.W. and Sim,S.K. (1977) The mechanism of bleomycin induced cleavage of DNA. Biochem. Biophys. Res. Commun., 77, 1150-1157.
19. Mitchell,J.B., Morstyn,G., Russo,A. and Caeney,D.N. (1985) In vitro radiobiology of human lung cancer. Cancer Treat. Symposium. 2,3.
20. Nagai,K., Suzuki,H., Tanaka,N. and Unezawa,H. (1969) Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of 2-Mercaptoethanol. J. Antibiotics, 22, 569-573.
21. Ohama,K. and Kadotani,T. (1970) Cytologic effects of bleomycin on cultured human leucocyte. Jap. J. Hum. Genet., 14, 293-297.
22. Ono,K. and Shrieve,D.C. (1986) Enhancement of EMT6/SF tumour cell killing by mitomycin C and cyclophosphamide following in vivo administration of buthionine sulfoximine. Int. J. Radiat. Oncol. Biol. Phys., 12, 1175.
23. Povirk,L.F. and Austin,N.J.F. (1991) Genotoxicity of bleomycin. Mutat. Res., 257, 127-143.
24. Puri,R.N. and Meister,A. (1983) Transport of glutathione as γ-glutamyl cysteinyl glycyl ester, into liver and kidney. Proc. Natl. Acad. Sci. USA, 80, 5258-5260.
25. Promchainant,C. (1975) Cytogenetic effect of bleomycin in human lymphocytes in vitro. Mutat. Res., 28, 107-112.
26. Russo,A., Mitchell,J.B., McPherson,S.J. and Friedman,N. (1984) Alteration of bleomycin cytotoxicity by glutathione depletion or elevation. Int. J. Rad. Onco. Biol. Phys., 10, 1675-1678.
27. Russo,A., Tochner,Z. and Phillips,T. (1986) In vivo modulation of glutathione by buthionine sulfoximine: effect on marrow response to melphalan. Int. J. Radiat. Oncol. Biol. Phys., 12, 1187-1191.
28. Sausville,E.A., Peisach,J. and Horowitz,S.B. (1976) A role of ferrous ion and oxygen in the degradation of DNA by bleomycin. Biochem. Biophys. Res. Commun., 73, 814-822.
29. Scott,D. and Zampetti-Bossler,F. (1985) Relationship between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays. Mutat. Res., 151, 83-88.
30. Suzuki,H., Nagai,K., Yamaki,H., Tanaka,N. and Umezawa,H. (1969) On the mechanism of action of bleomycin: Scission of DNA strand in vitro and in vivo. J. Antibiotics, 22, 446-448.
31. Takeshita,M., Grollman,A.P., Ohtusbo,E. and Ohtsubo,H. (1978) Interaction of bleomycin with DNA. Proc. Natl. Acad. Sci. USA, 75, 5983-5987.
32. Tsutsui,K., Komuro,C., Ono,K., Nishidai,T., Shibamato,Y., Takahashi,M. and Abe,M. (1986) Chromosensitization by buthionine sulfoximine in vivo. Int. J. Radiat. Oncol. Biol. Phys., 12, 1183-1185.
33. 2 by Fusarium acylagmatine aminohydrolase. J. Antibiotics, 26, 117-119.
34. Vig,B.K. and Lewis,R. (1978) Genetic toxicology of bleomycin. Mutat. Res., 55, 121-145.
35. Wellner,V.P., Anderson,M.E., Puri,R.N., Jensen,G.L. and Meister,A. (1984) Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc. Natl. Acad. Sci. USA, 81, 4732-4735.
36. Wolf,C.R., Lewis,A.D., Carmichael,J., Adam,D.J., Allan,S.G. and Anjell,D.J. (1987) The role of glutathione in determining the response of normal and tumour cells to anticancer drugs. In Biochemical Society Transactions, 620th meeting, Dublin.