LEC rats: An overview of recent findings

Journal of Trace Elements in Experimental Medicine

Volumn 10, Issue 2, 1997, Pages 135-145

  Miyoshi, Eiji ^a   Fujii, Junichi ^a   Hayashi, Norio ^a   Taniguchi, Naoyuki ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Hepatitis; Hepatocarcinogenesis; Hepatoma; LEC rats; Wilson's disease

Indexed keywords

ADENOSINE TRIPHOSPHATASE; COPPER; IRON;

ANIMAL MODEL; ARTICLE; COPPER METABOLISM; HEPATITIS; IMMUNE DEFICIENCY; IRON METABOLISM; LIVER CELL CARCINOMA; LIVER METABOLISM; LYMPHOCYTE DIFFERENTIATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; WILSON DISEASE;

EID: 0030857789     PISSN: 0896548X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-670X(1997)10:2<135::AID-JTRA11>3.0.CO;2-S     Document Type: Article

References (62)

1. Mori M, Yoshida MC, Takeichi N, Taniguchi N: "The LEG Rat: A New Model for Hepatitis and Liver Cancer." Tokyo: Springer-Verlag, 1991.
2. Li Y, Togashi Y, Sato S, Emoto T, Kang JH, Takeichi N, Kobayashi H, Kojima Y, Une Y, Uchino J: Spontaneous hepatic copper accumulation in Long-Evans cinnamon rats with hereditary hepatitis. J Clin Invest 87:1858-1861, 1991.
3. Togashi Y, Li Y, Kang JH, Takeichi N, Fujioka Y, Nagashima K, Kobayashi H: D-Penicillamine prevents the development of hepatitis in Long-Evans Cinnamon rats with abnormal copper metabolism. Hepatology 15:82-87, 1992.
4. Sone K, Maeda M, Wakabayashi K, Takeichi N, Mori M, Sugimura T, Nagao M: Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride. Hepatology 23:764-770, 1996.
5. Kato J, Kohgo Y, Sugawara N, Katsuki S, Shintani N, Fujikawa K, Miyazaki E, Kobune M, Takeichi N, Niitsu Y: Abnormal hepatic iron accumulation in LEC rats. Jpn J Cancer Res 84:219-222, 1993.
6. Suzuki K, Miyazawa N, Nakata T, Seo HG, Sugiyama T, Taniguchi N: High copper and iron levels and expression of Mn-superoxide dismutase in mutant rats displaying hereditary hepatitis and hepatoma (LEC rats). Carcinogenesis 14:1881-1884, 1993.
7. Sugawara N, Sugawara C, Sato M, Takahashi H, Mori M: Excessive accumulation of hepatic copper in LEC rats aged 80 days without hepatitis and 130 days with hepatitis. Pharmacol Toxicol 71:321-324, 1992.
8. Takahashi N, Ortel TL, Putnam FW: Single-chain structure of human ceruloplasmin: The complete amino acid sequence of the whole molecule. Proc Natl Acad Sci USA 81:390-394, 1984.
9. Sherlock S: "Diseases of the Liver and Biliary System," 8th ed. New York: Blackwell, 1989, pp 460-469.
10. Yamada T, Agui T, Suzuki Y, Sato M, Matsumoto K: Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rats. J Biol Chem 268:8965-8971, 1993.
11. Kato J, Kobune M, Kohgo Y, Sugawara N, Hisai H, Nakamura T, Sakamaki S, Sawada N, Niitsu Y: Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans cinnamon rats. J Clin Invest 98:923-929, 1996.
12. Our recent findings: Koizumi M, Fujii J, Suzuki K, Inoue T, Inoue T, Gutteridge JMC, Taniguchi N: Levels of free copper and free iron in the plasma and liver of LEC rats.
13. Sawaki M, Enomoto K, Hattori A, Tsuzuki N, Sugawara N, Mori M: Role of copper accumulation and methallothionein induction in spontaneous liver cancer development in LEC rats. Carcinogenesis 15:1833-1837, 1994.
14. Wilson SAK: Progressive lenticular degeneration: A familial nervous disease associated with cirrhosis of the liver. Brain 34:295-509, 1912.
15. Frydman M, Bonne-Tamir B, Farrer LA, Conneally PM, Magazanik A, Ashbel S, Goldwitch Z: Assignment of the gene for Wilson disease to chromosome 13: Linkage to the esterase D locus. Proc Natl Acad Sci USA 82:1819-1821, 1985.
16. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW: The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet 5:327-337, 1993.
17. Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J: Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nat Genet 3:7-13, 1993.
18. Chelly J, Turner Z, Tonnesen T, Petterson A, Ishikawa-Brush Y, Tommerup N, Horn N, Monaco AP: Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat Genet 3:14-19, 1993.
19. Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, Devoto M, Brzustowicz LM, Cayanis E, Vitale E, Russo JJ, Matseoane D, Boukhgalter B, Wasco W, Figus AL, Loudianos J, Cao A, Sternlieb I, Evgrafov O, Parano E, Pavone L, Warburton D, Ott J, Penchaszadeh GK, Scheinberg IH, Gilliam TC: Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nat Genet 5:338-343, 1993.
20. Solioz M, Vulpe C: CPx-type ATPases: A class of P-type ATPases that pump heavy metals. Trends Biochem Sci 21:237-241, 1996.
21. Thomas GR, Forbes JR, Roberts EA, Walsher JM, Cox DW: The Wilson disease gene: Spectrum of mutations and their consequences. Nat Genet 9:210-217, 1995.
22. Wu J, Forbes JR, Chen HS, Cox DW: The LEG rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat Genet 7:541-545, 1994.
23. Yamaguchi Y, Heiny ME, Shimizu N, Aoki T, Gitlin JD: Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Biochem J 301:1-4, 1994.
24. Matsuda R, Yoshida MC, Sasaki M, Dempo K, Mori M: Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene. Lab Anim Sci 22:166-169, 1988.
25. Muramatsu Y, Yamada T, Miura M, Sakai T, Suzuki Y, Serikawa T, Tanzi RE, Matsumoto K: Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans Cinnamon Rats. Gastroenterology 107:1189-1192, 1994.
26. Sasaki N, Hayashizaki Y, Kasai N: Absence of linkage between the retinoblastoma gene and hts gene in the LEC rat: A model of human Wilson's disease. Jpn J Cancer Res 84:1019-1022, 1993.
27. Nakamura K, Endo F, Ueno T, Awata H, Tanous A, Matsuda I: Excess copper and ceruloplasmin biosynthesis in Long-term cultured hepatocytes from Long-Evans Cinnamon (LEC) rats, a model of Wilson disease. J Biol Chem 270:7656-7660, 1995.
28. Matsumoto K, Takeichi N, Izumi K, Otsuka H: Quantitative variation in immunoglobin G (Igsr-1) in LEC rats associated with spontaneous hepatitis and hepatoma. Transplant Proc 21:3259, 1989.
29. - thymocytes in a mutant strain of rat. J Exp Med 172:1615-1624, 1990.
30. - thymocytes. Eur J Immunol 21:2537-2541, 1991.
31. Ikeda Y, Sugiyama T, Takahashi M, Taniguchi N: Selective suppression of IgG2a subclass in LEC rats during development. Biochim Biophys Acta 1200:277-280, 1994.
32. + T cells in LEC mutant rats. Cell Immunol 158:414-422, 1994.
33. + T cells of LEC mutant rats. Immunology 79:491-497, 1993.
34. + T cells. Eur J Immunol 25:1399-1404, 1995.
35. Gutteridge JMC, Halliwell B: Iron toxicity and oxygen radicals. In C. Hershko (ed): "Clinical Haematology: Iron Chelating Therapy" London: Bailliere Tindall, - , p 195-256.
36. Grootveld M, Bell JD, Halliwell B, Aruoma OI, Bonford A, Sadies PJ: Non-transferrin-bound iron in plasma or serum from patients with idiopathic haemochromatosis: Characterization by HPLC and NMR spectroscopy. J Biol Chem 264:4417-4421, 1989.
37. Halliwell B, Gutteridge JMC, Cross CE: Free radicals, antioxidants, and human diseases: Where are we now? J Lab Clin Med 6:598-620, 1992.
38. Hattori A, Sawaki M, Enomoto K, Tsuzuki N, Isomura H, Kojima T, Kamibayashi Y, Sugawara N, Sugiyama T, Mori M: The high hepatocarcinogen susceptibility of LEG rats is genetically independent of abnormal copper accumulation in the liver. Carcinogenesis 16:491-494, 1995.
39. Sugiyama T, Takeichi N, Kobayashi H, Yoshida MC, Sasaki M, Taniguchi N: Metabolic predisposition of a novel mutant (LEC rats) to hereditary hepatitis and hepatoma: Alterations of the drug metabolizing enzymes. Carcinogenesis 9:1569-1572, 1988.
40. Sugiyama T, Suzuki K, Ookawara T, Kurosawa T, Taniguchi N: Selective expression and induction of cytochrome P450PB and P450MC during the development of hereditary hepatitis and hepatoma of LEC rats. Carcinogenesis 10:2155-2159, 1989.
41. Takahashi M, Hoshi A, Fujii J, Miyoshi E, Kasahara T, Suzuki K, Aozasa K, Taniguchi N: Induction of aldose reductase gene expression in LEC rats during the development of the hereditary hepatitis and hepatomas. Jpn J Cancer Res 87:337-341, 1996.
42. Zeindl-Eberhart E, Jungblut PR, Otto A, Rabes HM: Identification of tumor-associated protein variants during rat hepatocarcinogenesis: Aldose reductase. J Biol Chem 269:14589-14594, 1994.
43. Sone H, Wakabayashi K, Kushida H, Enomoto K, Mori M, Takeichi N, Tsuda H, Sugimura T, Nagao M: Hepatocellular carcinoma induction in LEC rats by a low dose of 2-amino-3, 8-dimethylimidazole[4,5-f] quinoxaline. Jpn J Cancer Res 87:25-29, 1996.
44. Fujimoto Y, Ishizaka Y, Tahira T, Sone H, Takahashi H, Enomoto K, Mori M, Sugimura T, Nagao M: Possible involvement of c-myc but not ras genes in hepatocellular carcinomas developing after spontaneous hepatitis in LEC rats. Mol Carcinogenesis 4:269-274, 1991.
45. Sawaki M, Enomoto K, Takahashi H, Nakajima Y, Mori M: Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats. Carcinogenesis 11:1857-1861, 1990.
46. Masuda R, Yoshida MC, Sasaki M: Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats. Jpn J Cancer Res 80: 1024-1027, 1989.
47. Takahashi H, Oyamada M, Fujimoto Y, Satoh MI, Hattori A, Dempo K, Mori M, Tanaka T, Watabe H, Masuda R, Yoshida MC: Elevation of serum alpha-fetoprotein and proliferation of oval cells in the livers of LEC rats. Jpn J Cancer Res 79:821-827, 1988.
48. Sakamoto H, Sawada N, Kamimura Y, Enomoto K, Mori M: High sensitivity of LEC rats with chronic hepatitis to hepatocarcinogenesis: Decreases in unscheduled and replicative DNA synthesis of the hepatocytes. Jpn J Cancer Res 84:966-971, 1993.
49. Nair J, Sone H, Nagao M, Barbin A, Bartsch H: Copper-dependent formation of miscoding ethenoDNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma. Cancer Res 56:1267-1271, 1996.
50. Doerfler W: DNA methylation and gene activity. Annu Rev Biochem 52:93-124, 1983.
51. Suzuki K, Sugiyama T, Ookawara T, Kurosawa T, Taniguchi N: High sensitivity to 5-azacytidine in LEC rats, a strain with a metabolic predisposition to hepatitis and hepatoma. Biochem Int 23:9-14, 1991.
52. Miyoshi E, Jain SK, Sugiyama T, Fujii J, Hayashi N, Fusamoto H, Kamada T, Taniguchi N: Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis. Carcinogenesis 14:603-605, 1993.
53. Simizu K, Abe M, Yokoyama S, Takahashi H, Sawada N, Mori M, Tsukada K: Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats. Life Sci 46:1837-1842, 1990.
54. Sugiyama T, Matsunaga M, Jain SK, Jain S, Ikeda Y, Taniguchi N: Enhancing effect of a cholinedeficient diet on alterations of hepatic drug metabolizing enzymes in hepatitis- and hepatomapredisposed rats (LEC rats). Jpn J Cancer Res 82:390-396, 1991.
55. Rademacher TW, Parekh RB, Dwek RA: Glycobiology. Ann Rev Biochem 57:785-838, 1984.
56. Miyoshi E, Nishikawa A, Ihara Y, Gu J, Sugiyama T, Hayashi N, Fusamoto H, Kamada T, Taniguchi N: N-Acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis. Cancer Res 53:3899-3902, 1993.
57. Gu J, Nishikawa A, Matsuura N, Sugiyama T, Taniguchi N: Deficiency of β1-6 N-acetylglucosaminyltransferase involved in the biosynthesis of blood group I antigen in the liver of LEC rats. Jpn J Cancer Res 83:878-884, 1992.
58. Nakayama N, Kashiwazaki H, Kobayashi N, Hamada J, Matsumoto K, Nakamura T, Takeichi N: Differing distribution of hepatocyte growth factor-positive cells in the liver of LEC rats with acute hepatitis, chronic hepatitis and hepatoma. Jpn J Cancer Res 86:5-9, 1995.
59. Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936-939, 1991.
60. Inui Y, Higashiyama S, Kawata S, Tamura S, Miyagawa J, Taniguchi N, Matsuzawa Y: Expression of heparin-binding epidermal growth factor in human hepatocellular carcinoma. Gastroenterology 107:1799-1804, 1994.
61. Miyoshi E, Higashiyama S, Nakagawa T, Suzuki K, Horimoto M, Hayashi N, Fusamoto H, Kamada T, Taniguchi N: High expression of heparin-binding EGF-like growth factor in rat hepatocarcinogenesis. Int J Cancer 68:215-218, 1996.
62. Yoshida Y, Tokusashi Y, Lee GH, Ogawa K: Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans Cinnamon Rats. Gastroenterology 111:1654-1660, 1996.