Effects of estrogen and tamoxifen on the MAP kinase cascade in experimental rat breast cancer

International Journal of Oncology

Volumn 11, Issue 3, 1997, Pages 583-589

  Koibuchi, Yukio ^a   Iino, Yuichi ^a   Uchida, Tsutomu ^a   Nagasawa, Masahiro ^a   Morishita, Yasuo ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

17 estradiol; Breast cancer; MAP kinase; MAP kinase kinase; Raf 1; Tamoxifen

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ESTRADIOL; ESTROGEN; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; NONHUMAN; ORAL DRUG ADMINISTRATION; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR VOLUME;

EID: 0030857651     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.11.3.583     Document Type: Article

References (17)

1. Sturgill TW, Ray LB, Erikson E and Maller JL: Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 334: 715-718, 1988.
2. Kohno M: Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells. J Biol Chem 260: 1771-1779, 1985.
3. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH and Yancopoulos GD: ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insufin and NGF. Cell 65: 663-675, 1991.
4. Nishida E and Gotoh Y: Mitogen-activated protein kinase and cytoskeleton in mitogenic signal transduction. Int Rev Cytol 138: 211-238, 1992.
5. Blenis J: Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 90: 5889-5892, 1993.
6. Davis RJ: The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268: 14553-14556, 1993.
7. Crews CM, Alessandrini A and Erikson RL: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258: 478-480, 1992.
8. Seger R, Seger D, Lozeman FJ, Ahn NG, Graves LM, Campbell JS, Ericsson L, Harrylock M, Jensen AM and Krebs EG: Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J Biol Chem 267: 25628-25631, 1992.
9. Zheng CF and Guan KL: Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem 268: 11435-11439, 1993.
10. Thomas SM, DeMarco M, D'Arcangelo G, Halegoua S and Brugge JS: Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68: 1031-1040, 1992.
11. Wood KW. Sarnecki C, Roberts TM and Blenis J: ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68: 1041-1050, 1992.
12. Robbins DJ, Cheng M, Zhen E, Vanderbilt CA, Feig LA and Cobb MH: Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci USA 89: 6924-6928, 1992.
13. De-Vries Smits AM, Burgering BM, Leevers SJ, Marshall CJ and Bos JL: Involvement of p21ras in activation of extracellular signal-regulated kinase 2. Nature 357: 602-604, 1992.
14. Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR and Avruch J: Raf-1 activates MAP kinase kinase. Nature 358: 417-421, 1992.
15. Howe LR, Leevers SJ, Gomez N, Nakielny S, Cohen P and Marshall CJ: Activation of the MAP kinase pathway by the protein kinase raf. Cell 71: 335-342, 1992.
16. Lippman ME and Dickson RB: Mechanisms of growth control in normal and malignant breast epithelium. Recent Prog Horm Res 45: 383-440, 1989.
17. Yee D, Paik S, Lebovic GS, Marcus RR, Favoni RE, Cullen KJ, Lippman ME and Rosen N: Analysis of insulin-like growth factor-I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol 3: 509-517, 1989.