Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis

Journal of Rheumatology

Volumn 24, Issue 7, 1997, Pages 1324-1331

  Zernicke, Ronald F ^a   Wohl, Gregory R ^a   Greenwald, Robert A ^b   Moak, Susan A ^b   Leng, Winnie ^a   Golub, Lorne M ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Adjuvant arthritis; Biomechanics; Bone; Collagenase; Tetracycline

Indexed keywords

FLURBIPROFEN; MATRIX METALLOPROTEINASE INHIBITOR; TENIDAP; TETRACYCLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BIOMECHANICS; BONE METABOLISM; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; BODY WEIGHT; COLLAGENASES; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; FEMUR NECK; FLURBIPROFEN; INDOLES; MALE; METALLOENDOPEPTIDASES; RATS; RATS, INBRED LEW; TETRACYCLINES; WEIGHT-BEARING;

EID: 0030857355     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Towheed TE, Brouillard D, Yendt E, Anastassiades T: Osteoporosis in rheumatoid arthritis: Findings in the metacarpal, spine, and hip and a study of the determinants of both localized and generalized osteopenia. J Rheumatol 1995;22:440-3.
2. Brinckerhoff CE: Joint destruction in arthritis; Metalloproteinases in the spotlight. Arthritis Rheum 1991;34:1073-5.
3. Greenwald RA, Moak SA, Ramamurthy NS, Golub LM: Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage. J Rheumatol 1992;19:927-38.
4. Bauer EA, Eisen AZ, Jeffrey JJ: Studies on purified rheumatoid synovial collagenase in vitro and in vivo. J Clin Invest 1964;50:2056-64.
5. Al-Haik N, Lewis DA, Struthers G: Neutral protease, collagenase, and elastase activities in synovial fluids from arthritic patients. Agents Actions 1984;15:436-42.
6. Gravallese EM, Darling JM, Lad AL, Katz JN, Glimcher LM: In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum 1991;34:1076-84.
7. Macachren SS: Expression of metalloproteinases and metalloproteinase inhibitor in human arthritic synovium. Arthritis Rheum 1991;34:1085-93.
8. Okada Y, Gonoji Y, Nakanishi I, Nagase H, Hayakawa T: Immunohistochemical demonstration of collagenase and tissue inhibitor of metalloproteinases in synovial lining cells of rheumatoid synovium. Virchow Archiv (B) 1990;59:305-12.
9. Wooley DE, Crossley MJ, Evanson JM: Collagenase at sites of cartilage erosion in the rheumatoid joint. Arthritis Rheum 1977;20:1231-9.
10. Harris ED Jr, Welsug HG, Krane SM: Regulation of the mammalian collagenases. Collagen Related Res 1984;4:493-512.
11. Chang KM, Ramamurthy NS, McNamara TF, et al: Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism. J Periodont Res 1994;29:242-9.
12. Golub LM, McNamara RF, D'Angelo G, Greenwald RA, Ramamurthy NS: A non-antibacterial chemically modified tetracycline inhibits mammalian collagenase activity. J Dental Res 1987;66:1310-4.
13. Golub LM, Lee HM, Nemiroff A, McNamara TF, Kaplan R, Ramamurthy NS: Minocycline reduces gingival collagenolytic activity during diabetes; preliminary observations and a proposed new mechanism of action. J Periodont Res 1983;18:516-26.
14. Golub LM, Wolff M, Lee HM, et al: Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources. J Periodont Res 1985;20:12-23.
15. Golub LM, Greenwald RA, Ramamurthy NS, McNamara TF, Rifkin BR: Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991;2:297-321.
16. Golub LM, Ramamurthy NS, Kaneko H, Sasaki T, Rifkin B, McNamara TF: Tetracycline administration prevents diabetes-induced osteopenia in the rat - initial observations. Res Commun Chem Pathol 1990;68:27-40.
17. Gomes BC, Golub LM, Ramamurthy NS: Tetracyclines inhibit parathyroid hormone-induced bone resorption in organ culture. Experientia 1984;40:1273-5.
18. Greenwald RA, Simonson BG, Moak SA, et al: Inhibition of epiphyseal cartilage collagenase by tetracyclines in low phosphate rickets in rats. J Orthop Res 1988;6:695-703.
19. Greenwald RA, Golub LM, Lavietes B, et al: Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J Rheumatol 1987;14:28-32.
20. Yu LP, Smith GN, Brandt KD: Doxycycline inhibits Type XI collagenolytic activity of extracts from human osteoarthritis cartilage and of gelatinase. J Rheumatol 1991;18:1450-2.
21. Lanigan EP, Bain SD, Rubin CT: Structural quality of the proximal femur in diabetic rat treated with minocycline. Proc Am Soc Biomech 1990;14:23-4.
22. Chang KM, Ramamurthy NS, McNamara TF, et al: Tetracyclines inhibit Porphyromonas gingivalis induced alveolar bone loss in rats by a non-antimicrobial mechanism. J Periodont Res 1994;29:242-9.
23. Sasaki T, Kaneko H, Ramamurthy NS, Golub LM: Tetracycline administration restores osteoblast structure and function during experimental diabetes. Anat Rec 1991;231:25-34.
24. Sasaki T, Ramamurthy NS, Golub LM: Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats: A quantitative autoradiographic study. Calcif Tissue Int 1992;50:411-9.
25. Kaneko H, Sasaki T, Ramamurthy NS, Golub LM: Tetracycline administration normalizes the structure and acid phosphatase activity of osteoclasts in streptozotocin-induced diabetic rats. Anat Rec 1990;227:427-36.
26. Rifkin BR, Vernillo AT, Golub LM, Ramamurthy NS: Modulation of bone resorption by tetracyclines. Ann NY Acad Sci 1994;732:165-80.
27. Greenwald RA, Moak SA, Ramamurthy NS, Golub LM: Metalloproteinase inhibitors suppress pathologically excessive collagen crosslink excretion in adjuvant arthritis (abstr). Arthritis Rheum 1993;(suppl)36:S45.
28. Yu Z, Ramamurthy NS, Leung M, Chang KM, McNamara TF, Golub LM: Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: A dose-response study. J Periodont Res 1993;28:420-8.
29. Seyedin SM, Kung VT, Daniloff YN, et al: Immunoassay for urinary pyridinoline: The new marker of bone resorption. J Bone Miner Res 1993;8:635-41.
30. Kamel S, Brazier M, Picard C, et al: Urinary excretion of pyridinolines crosslinks measured by immunoassay and HPLC technique in normal subjects and in elderly patients with vitamin D deficiency. Bone & Mineral 1994;26:197-208.
31. Fledelius C, Riis BJ, Overgaard K, Christiansen C: The diagnostic validity of urinary free pyridinolines to identify women at risk of osteoporosis. Calcif Tissue Int 1994;54:381-4.
32. Hou JC-H, Zernicke RF, Barnard RJ: Effects of diabetes severity and insulin on femoral neck morphology and mechanics. J Orthop Res 1993;11:263-71.
33. Zernicke RF, Salem GJ, Barnard RJ, Schramm E: Long-term, high-fat-sucrose diet alters rat femoral neck and vertebral morphology, bone mineral content, and mechanical properties. Bone 1995;16:25-31.
34. Gies AA, Carter DR, Sartoris DJ, Sommer FG: Femoral neck strength predicted from dual energy projected radiography (abstr). Trans Orthop Res Soc 1985;10:357.
35. Atteh JO, Leeson S, Julian JR: Effects of dietary levels and types of fat on performance and mineral metabolism of broiler chicks. Poultr Sci 1983;62:2403-11.
36. Mohr W, Wild A, Wolf HP: Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats. Ann Rheum Dis 1981;40:171-6.
37. Coffey JW, Salvador RA: Levels of collagenolytic activity, β-glucuronidase and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis. Biochim Biophys Acta 1981;677:243-52.
38. Kuberasampath T, Bose SM: Effect of adjuvant arthritis on collagenase and certain lysosomal enzymes in relation to the catabolism of collagen. Agents Actions 1980;10:78-84.
39. Otterness IG, Larson DK, Lombardino JG: An analysis of piroxicam in rodent models of arthritis. Agents Actions 1982;12:308-12.
40. Williams RC, Jeffcoat MK, Howell TH, et al: Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. J Periodontol 1989;60:485-90.
41. Williams RC, Jeffcoat MK, Kaplan ML, Goldhaber P, Johnson HG, Wechter WJ: Flurbiprofen: A potent inhibitor of alveolar bone resorption in beagles. Science 1985;227:640-2.
42. Otterness IG, Bliven ML: Laboratory models for testing non-steroidal anti-inflammatory drugs. In: JG Lombardino, ed. Non-Steroidal Anti-Inflammatory Drugs. New York: Wiley, 1985.
43. Fernandes JC, Martel-Pelletier J, Otterness IG, et al: Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis. Arthritis Rheum 1995;38:1290-303.
44. Ramamurthy NS, Golub LM: Diabetes increases collagenase activity in extracts of rat gingiva and skin. J Periodont Res 1983;18:23-30.
45. Nicoll GA, Gollapudi GM, Ramamurthy NS, Golub LM: Suppressed collagenolytic activity in polymorphonuclear leukocytes from diabetic humans. Experientia 1981;37:315-7.
46. Golub LM, Ciancio S, Ramamurthy NS, Leung M, McNamara TF: Low dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans. J Periodont Res 1990;25:321-30.
47. Donahue HJ, Iijima K, Goligorsky MS, Rubin CT, Rifkin BR: Regulation of cytoplasmic calcium concentration in tetracycline-treated osteoclasts. J Bone Miner Res 1992;7:1313-8.