Platelet-derived growth factor in human brain tumors

Journal of Neuro-Oncology

Volumn 35, Issue 3, 1997, Pages 289-301

  Kirsch, Matthias ^a,b   Wilson, John C ^a   Black, Peter ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; NIFEDIPINE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; SURAMIN; VERAPAMIL;

ANTINEOPLASTIC ACTIVITY; ASTROCYTOMA; BRAIN TUMOR; HUMAN; HYPOPHYSIS ADENOMA; MENINGIOMA; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN NEOPLASMS; HUMANS; PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 0030856861     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005872718547     Document Type: Review

References (103)

1. Cross M, Dexter TM: Growth factors in development, transformation, and tumorigenesis. Cell 64: 271-280, 1991
2. Weinberg RA : The molecular basis of oncogenes and tumor suppressor genes. Ann NY Acad Sci 758: 331-338, 1995
3. Antoniades HN: PDGF: a multifunctional growth factor. Baillieres Clin Endocrinol Metabol 5: 595-613, 1991
4. Kaplan DR, Chao FC, Stiles CD, Antoniades HN and Scher CD : Platelet alpha granules contain a growth factor for fibroblasts. Blood 53: 1043-1052, 1979
5. Antoniades HN, Scher CD, Stiles CD : Purification of human platelet-derived growth factor. Proc Natl Acad Sci USA 76: 1809-1813, 1979
6. Bowen-Pope DF, Hart CE, Seifert RA : Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor. J Biol Chem 264: 2502-2508, 1989
7. Yarden Y, Escobedo JA, Kuang WJ, Yang-Feng TL, Daniel TO, Tremble PM, Chen EY, Ando ME, Harkins RN, Francke U, et al.: Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323: 226-232, 1986
8. Hsieh CL, Navankasattusas S, Escobedo JA, Williams LT, Francke U : Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice. Cytogenet Cell Genet 56: 160-163, 1991
9. Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S: Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243: 800-804, 1989
10. Heldin CH, Backstrom G, Ostman A, Hammacher A, Ronnstrand L, Rubin K, Nister M, Westermark B: Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J 7: 1387-1393, 1988
11. Hart CE, Forstrom JW, Kelly JD, Seifert RA, Smith RA, Ross R, Murray MJ, Bowen-Pope DF: Two Classes of PDGF Receptor Recognize Different Isoforms of PDGF. Science 240: 1529-1531, 1988
12. Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T: Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science 250: 979-982, 1990
13. Ellis C, Moran M, McCormick F, Pawson T: Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature 343: 377-381, 1990
14. Khosravi-Far R, Der CJ : The Ras signal transduction pathway. Cancer Metastasis Rev 13: 67-89, 1994
15. Trahey M, McCormick F: A cytoplasmicprotein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238: 542-545, 1987
16. Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG : Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc Natl Acad Sci USA 91: 7335-7339, 1994
17. Morrison DK, Kaplan DR, Escobedo JA, Rapp UR, Roberts TM, Williams LT: Direct activation of the serine/ threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell 58: 649-657, 1989
18. Morrison DK, Kaplan DR, Rapp U, Roberts TM: Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci USA 85: 8855-8859, 1988
19. Todo T, Fahlbusch R: Involvement of protein kinase C in growth regulation of human meningioma cells. Acta Neurochir 131: 282-288, 1994
20. Ahmad S, Mineta T, Martuza RL, Glazer RI: Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. Neurosurgery 35: 904-8, 1994
21. Pollack IF, Randall MS, Kristofik MP, Kelly RH, Selker RG, Vertosick, FT J: Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways. J Neurosurg 73: 98-105, 1990
22. Fisch TM, Prywes R, Simon MC, Roeder RG : Multiple sequence elements in the c-fos promoter mediate induction by cAMP. Genes Dev 3: 198-211, 1989
23. Tsai CH, Hung LM, Chen JK: Perturbation of the platelet-derived growth factor receptor signaling by dibutyryl-cAMP in human astrocytoma cells. J Cell Physiol 164: 108-116, 1995
24. Harsh GR, Kavanaugh WM, Starksen NF, Williams LT: Cyclic AMP blocks expression of the c-sis gene in tumor cells. Oncogene Research 4: 65-73, 1989
25. Tsai CH, Hung LM, Cheng HP, Chen JK: Increased intracellular cyclic AMP levels suppress the mitogenic responses of human astrocytoma cells to growth factors. J Neuro-Oncol 23: 41-52, 1995
26. Mundschau LJ, Forman LW, Weng H, Faller DV: Platelet-derived growth factor (PDGF) induction of egr-1 is independent of PDGF receptor autophosphorylation on tyrosine. J Biol Chem 269: 16137-16142, 1994
27. Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S: Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381: 800-803, 1996
28. Surmacz E, Reiss K, Sell C, Baserga R : Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts. Cancer Res 52: 4522-4525, 1992
29. Lillien LE, Raff CM: Differentiation signals in the CNS: Type-2 astrocyte development in vitro as a model system. Neuron 5: 111-119, 1990
30. Linskey MS: The Developmental Biology of Glial and its Relation to the Study of Glioma Biology. Apuzzo LJ (ed) Benign Cerebral Glioma, American Association of Neurological Surgeons, Park Ridge, Illinois, 1995 pp. 13-54
31. Watkins B, Bevan K, Venter D, Noble M: Glial cell markers in the study of CNS development and human gliomas. Thomas GTT (ed) Neuro-oncology: Primary malignant brain tumors, The Johns Hopkins University Press, Baltimore, 1990 pp. 40-50,
32. Bailey P, Cushing H : A classification of the tumors of the glioma group on a histogenetic basis with a correlated study of prognosis. J.B.Lippincott Company, Philadelphia. 1926
33. Bogler O, Wren D, Barnett SC, Land H, Noble M: Cooperation between two growth factors promotes extended selfrenewal and inhibits differentiation of oligodendrocytetype-2 astrocyte (O-2A) progenitor cells. Proc Nat Acad Sci USA 87: 6368-6372, 1990
34. Vemuri GS, McMorris FA: Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development 122: 2529-2537, 1996
35. Barres BA, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WDR, MC.: Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70: 31-46, 1992
36. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD : Programmed cell death and the control of cell survival: lessons from the nervous system. [Review]. Science 262: 695-700, 1993
37. LaRochelle WJ, Giese N, May-Siroff M, Robbins KC, Aaronson SA : Molecular localization of the transforming and secretory properties of PDGF A and PDGF B. Science 248: 1541-1544, 1990
38. Beckmann MP, Betsholtz C, Heldin CH, Westermark B, Di Marco E, Di, Fiore PP, Robbins KC, Aaronson SA : Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 241: 1346-1349, 1988
39. Smart I, Leblond CP: Evidence for division and transformation of neuroglia cells in the mouse brain as derived from autoradiography after injection of thymidine H-3. J Comp Neurol 116: 349-367, 1961
40. Dalton MM, Hommes OR, Leblond CP: Correlation of glial proliferation with age in the mouse brain. J Comp Neurol 134: 397-400, 1968
41. Korr H : Proliferation of different cell types in the brain. Adv Anat Embryol Cell Biol 61: 1-72, 1980
42. Sasahara M, Fries JW, Raines EW, Gown AM, Westrum LE, Frosch MP, Bonthron DT, Ross R, Collins T: PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell 64: 217-227, 1991
43. Yeh HJ, Ruit KG, Wang YX, Parks WC, Snider WD, Deuel TF: PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell 64: 209-216, 1991
44. Yeh HJ, Silos-Santiago I, Wang YX, George RJ, Snider WD, Deuel TF: Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system. Proc Natl Acad Sci USA 90: 1952-1956, 1993
45. Smits A, Kato M, Westermark B, Nister M, Heldin CH, Funa K: Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. Proc Natl Acad Sci USA 88: 8159-8163, 1991
46. Hart IK, Richardson WD, Heldin CH, Westermark B, Raff MC: PDGF receptors on cells of the oligodendrocytetype-2 astrocyte (O-2A) cell lineage. Development 105: 595-603, 1989
47. Pringle NP, Mudhar HS, Collarini EJ, Richardson WD: PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development 115: 535-551, 1992
48. Mudhar HS, Pollock RA, Wang C, Stiles CD, Richardson WD : PDGF and its receptors in the developing rodent retina and optic nerve. Development 118: 539-552, 1993
49. Yong VW, Kim SU, Pleasure DE : Growth factors for fetal and adult human astrocytes in culture. Brain Res 444: 59-66, 1988
50. Zetter BR, Antoniades HN: Stimulation of human vascular endothelial cell growth by a platelet-derived growth factor and thrombin. J Supramol Struct 11: 361-370, 1979
51. Antoniades HN, Galanopoulos T, Neville-Golden J, O'Hara CJ: Malignant epithelial cells in primary human lung carcinomas co-express in vivo platelet derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc Natl Acad Sci USA 89: 3942-3946, 1992
52. Kavanaugh WM, Harsh GR, 4th, Starksen NF, Rocco CM, Williams LT: Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells. J Biol Chem 263: 8470-8472, 1988
53. Harsh GR, Keating MT, Escobedo JA, Williams LT: Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. J Neuro-Oncol 8: 1-12, 1990
54. Hammacher A, Nister M, Westermark B, Heldin CH : A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet-derived growth factor. Eur J Biochem 176: 179-186, 1988
55. Nister M, Libermann TA, Betsholtz C, Pettersson M, Claesson-Welsh LH, CH, Schlessinger J, Westermark B: Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. Cancer Res 48: 3910-3918, 1988
56. Deinhardt F: Biology of primate retroviruses. In: Klein G (ed) Viral Oncology, Raven Press, New York, 1980 pp. 357-398,
57. Deuel TF, Pierce GF, Yeh HJ, Shawver LK, Milner PG, Kimura A: Platelet-derived growth factor/sis in normal and neoplastic cell growth. J Cell Physiol Suppl 5: 95-99, 1987
58. Keating MT, Williams LT: Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science 239: 914-916, 1988
59. Bejcek BE, Li DY, Deuel TF: Transformation by v-sis occurs by an internal autoactivation mechanism. Science 245: 1496-1499, 1989
60. Lens PF, Altena B, Nusse R : Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea. Mol Cell Biol 6: 3537-3540, 1986
61. Kumabe T, Sohma Y, Kayama T, Yoshimoto T, Yamamoto T: Amplification of a-platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin. Oncogene 7: 627-633, 1992
62. Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson, SA, Ali IU : Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52: 4550-4553, 1992
63. Schwechheimer K, Huang S, Cavenee WK: EGFR gene amplification-rearrangement in human glioblastomas. Int J Cane 62: 145-148, 1995
64. Burgart LJ, Robinson RA, Haddad SF, Moore SA : Oncogene abnormalities in astrocytomas: EGF-R gene alone appears to be more frequently amplified and rearranged compared with other protooncogenes. Modern Pathol 4: 183-186, 1991
65. Harsh GR, 4th, Rosenblum ML, Williams LT: Oncogene-related growth factors and growth factor receptors in human malignant glioma-derived cell lines. J Neuro-Oncol 7: 47-56, 1989
66. Nister M, Claesson-Welsh L, Eriksson A, Heldin CH, Westermark B : Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. J Biol Chem 266: 16755-16763, 1991
67. Guha A, Dashner K, Black PM, Wagner JA, Stiles CD : Expression of pdgf and pdgf receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer 60: 168-173, 1995
68. Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin CH, Westermark B, Nister M: Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res 52: 3213-3219, 1992
69. Guha A, Dashner K, Black PM, Wagner JA, Stiles CD : Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer 60: 168-173, 1995
70. Maxwell M, Naber SP, Wolfe HJ, Galanopoulos T, Hedley-Whyte ET, Black PM, Antoniades HN: Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. J Clin Invest 86: 131-140, 1990
71. Mauro A, Bulfone A, Turco E, Schiffer D : Coexpression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas. Childs Nerv Syst 7: 432-436, 1991
72. Plate KH, Breier G, Farrell CL, Risau W: Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. Lab Invest 67: 529-534, 1992
73. Hermansson M, Nister M, Betsholtz C, Heldin CH, Westermark B, Funa K: Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc Natl Acad Sci USA 85: 7748-7752, 1988
74. Black P, Carroll RS, Glowacka D : Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas. Pediatr Neurosurg 24: 74-78, 1996
75. Black PM, Carroll R, Glowacka D, Riley K, Dashner K: Platelet-derived growth factor expression and stimulation in human meningiomas. J Neurosurg 81: 388-393, 1994
76. Todo T, Adams EF, Fahlbusch R, Dingermann T, Werner H: Autocrine growth stimulation of human meningioma cells by platelet-derived growth factor. Journal of Neurosurgery 84: 852-8, 1996
77. Wang JL, Nister M, Hermansson M, Westermark B, Ponten J: Expression of PDGF beta-receptors in human meningioma cells. International Journal of Cancer 46: 772-778, 1990
78. Maxwell M, Galanopoulos T, Hedley-Whyte ET, Black PM, Antoniades HN: Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products. Int J Cancer 46: 16-21, 1990
79. Figarella-Branger D, Vagner-Capodano AM, Bouillot P, Graziani NG, D, Devictor B, Zattara-Cannoni H, Bianco N, Grisoli FP, JF.: Platelet-derived growth factor (PDGF) and receptor (PDGFR) expression in human meningiomas: correlations with clinicopathological features and cytogenetic analysis. Neuropathol Appl Neurobiol 20: 439-447, 1994
80. Leon SP, Carroll RS, Dashner K, Glowacka D, Black PM: Messenger ribonucleic acid expression of platelet-derived growth factor subunits and receptors in pituitary adenomas. J Clin Endocrinol Metabol 79: 51-55, 1994
81. Smits A, van Grieken D, Hartman M, Lendahl U, Funa K, Nister M: Coexpression of platelet-derived growth factor alpha and beta receptors on medulloblastomas and other primitive neuroectodermal tumors is consistent with an immature stem cell and neuronal derivation. Lab Invest 74: 188-198, 1996
82. Schrell UM, Gauer S, Kiesewetter F, Bickel A, Hren J, Adams EFF, R.: Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. J Neurosurg 82: 600-607, 1995
83. Tsai JC, Goldman CK, Gillespie GY: Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg 82: 864-873, 1995
84. Bando K, Kannuki S, Rokutan K, Shouno M, Matsumoto K: Effects of trapidil and suramin on growth factor-induced calcium response and tyrosine phosphorylation in human glioma cells. Neurol Med-Chir 35: 631-638, 1995
85. Firsching A, Nickel P, Mora P, Allolio B : Antiproliferative and angiostatic activity of suramin analogues. Cancer Res 55: 4957-4961, 1995
86. Kuratsu J, Ushio Y: Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro. J Neurosurg 73: 436-440, 1990
87. Hosang M: Suramin binds to platelet-derived growth factor and inhibits its biological activity. J Cell Biochem 29: 265-273, 1985
88. Middaugh CR, Mach H, Burke CJ, Volkin DB, Dabora JM, Tsai PK, Bruner, MW, Ryan JA, Marfia KE : Nature of the interaction of growth factors with suramin. Biochemistry 31: 9016-9024,1992
89. Westphal M, Ackermann E, Hoppe J, Herrmann HD : Receptors for platelet derived growth factor in human glioma cell lines and influence of suramin on cell proliferation. J Neuro-Oncol 11: 207-213, 1991
90. Vassbotn FS, Ostman A, Langeland N, Holmsen H, Westermark B, Heldin, CH, Nister M: Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. J Cell Physiol 158: 381-389, 1994
91. Coomber BL: Suramin inhibits C6 glioma-induced angiogenesis in vitro. J Cell Biochem 58: 199-207, 1995
92. Gagliardi A, Hadd H, Collins DC: Inhibition of angiogenesis by suramin. Cancer Res 52: 5073-5075, 1992
93. Takano S, Gately S, Neville ME, Herblin WF, Gross JL, Engelhard H, Perricone M, Eidsvoog K, Brem S: Suramin, an anticancer and angio suppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator. Cancer Res 54: 2654-2660, 1994
94. Tada M, Aida T, Hosokawa M, Kobayashi H, Sawamura Y, Abe H: Antiproliferative effect of trapidil on PDGF-associated growth of human glioma cell lines in vitro. Neurol Med-Chir 31: 313-317, 1991
95. Todo T, Adams EF, Fahlbusch R : Inhibitory effect of trapidil on human meningioma cell proliferation via interruption of autocrine growth stimulation. J Neurosurg 78: 463-469, 1993
96. Kovalenko M, Gazit A, Bohmer A, Rorsman C, Ronnstrand L, Heldin CH, Waltenberger J, Bohmer FD, Levitzki A : Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54: 6106-6114, 1994
97. Jensen RL, Origitano TC, Lee YS, Weber M, Wurster RD : In vitro growth inhibition of growth factor-stimulated meningioma cells by calcium channel antagonists. Neurosurgery 36: 365-73, 1995
98. Jensen RL, Lee YS, Guijrati M, Origitano TC, Wurster RD, Reichman OH : Inhibition of in vitro meningioma proliferation after growth factor stimulation by calcium channel antagonists: Part II-Additional growth factors, growth factor receptor immunohistochemistry, and intracellular calcium measurements. Neurosurgery 37: 937-46, 1995
99. MercolaM, Deininger PL, Shamah SM, Porter J, Wang CY, Stiles CD : Dominant-negative mutants of a platelet-derived growth factor gene. Genes Dev 4: 2333-2341, 1990
100. Shamah SM, Stiles CD, Guha A: Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol 13: 7203-7212, 1993
101. Vassbotn FS, Havnen OK, Heldin CH, Holmsen H : Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. J Biol Chem 269: 13874-13879, 1994
102. Strawn LM, Mann E, Elliger SS, Chu LM, Germain LL, Niederfellner G, Ullrich A, Shawver LK: Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor. J Biol Chem 269: 21215-21222, 1994
103. Guha A, Lau N, Pawson T 1996: Ras Mediated Proliferation of Human Astrocytoma Cells. American Association of Neurological Surgeons (Abstract)