1β-methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 3. Synthesis and antibacterial activity of BO-2727 and its related compounds

Journal of Antibiotics

Volumn 50, Issue 7, 1997, Pages 598-613

  Ohtake, Norikazu ^a   Okamoto, Osamu ^a   Mitomo, Ryuji ^a   Kato, Yoshiaki ^a   Yamamoto, Katsumi ^a   Haga, Yuji ^a   Fukatsu, Hiroshi ^a   Nakagawa, Susumu ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; IMIPENEM; KIDNEY ENZYME; LENAPENEM; MEROPENEM;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0030856782     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.598     Document Type: Article

References (9)

1. OKAMOTO, O.; H. FUKATSU, S. NAKAGAWA & N. TAKNAKA: BO-2727 and its related compounds, new β-methylcarbapenems. Program and Abstracts of 33rd Intersci. Conf. on Antimicrob. Agents Chemother., No. 898, New Orleans, 1993
2. SHIH, D. H.; F. BAKER, L. CAMA & B. G. CHRISTENSEN: Synthetic carbapenem antibiotics I, 1β-methylcarbapenem. Heterocycles 21: 29-40, 1984
3. OHTAKE, N.; O. OKAMOTO, S. KATO, R. USHIJIMA, H. FUKATSU & S. NAKAGAWA: 1β-methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 2. Synthesis and antibacterial activity of 5-aminopropyl and 5-aminopropenyl derivatives. J. Antibiotics 50: 586-597, 1997
4. MORI, S.; T. OHNO, H. HARADA, T. AOYAMA & T. SHIOIRI: New methods and reagents in organic synthesis. 92. A stereoselective synthesis of tilivalline and its analogs. Terahedron 47: 5051-5079, 1991
5. HANSON, G. J.; J. S. BARAN &T. LINDBERG: Stereoselective addition of lithioethyl acetate to Boc-L-prolinal. A conveinient chiral synthetic building block for the pyrrolizidine alkaloid ring system.Terahedron Lett. 27: 3577-3580, 1986
6. SOAI, K.; H. OYAMADA & M. TAKASE: The preparation of N-protected amino alcohols and N-protected peptide alcohol by reduction of the corresponding esters with sodium borohydride. An improved procedure involving a slow addition of a small amount of methanol. Bull. Chem. Soc. Jpn. 57: 2327-2328, 1984
7. OHTAKE, N.; K. YAMABA, O. OKAMOTO, E. MANO, R. USHIJIMA & S. NAKAGAWA: 1β-methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 1. Synthesis and antibacterial activity of BO-2502A and its related compounds. J. Antibiotics 50: 567-585, 1997
8. NAKAGAWA, S.; T. HASHIZUME, K. MATSUDA, M. SANADA, O. OKAMOTO, H. FUKATSU & N. TANAKA: In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity. Antimicrob. Agents Chemother. 37: 2756-2759, 1993
9. ASAHI, Y.; S. MIYAZAKI & K. YMAGUCHI: In vitro and in vivo antibacterial activities of BO-2727, a new carbapenem. Antimicrob. Agents Chemother. 39: 1030-1037, 1995