Metabolism of cAMP to adenosine in the renal vasculature

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 1, 1997, Pages 177-182

  Jackson, Edwin K ^a   Mi, Zaichuan ^a   Gillespie, Delbert G ^a   Dubey, Raghvendra K ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE PHOSPHATE; CYCLIC AMP; INOSINE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; PROBENECID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ISOLATED KIDNEY; KIDNEY BLOOD VESSEL; KIDNEY METABOLISM; MALE; MESENTERY BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; PURINE METABOLISM; RAT; VASCULAR SMOOTH MUSCLE;

1-METHYL-3-ISOBUTYLXANTHINE; ADENOSINE; ANIMALS; CELLS, CULTURED; CYCLIC AMP; MALE; MUSCLE, SMOOTH, VASCULAR; PERFUSION; PROBENECID; RATS; RATS, SPRAGUE-DAWLEY; RENAL VEINS;

EID: 0030856004     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. + ATPase in rat vascular smooth muscle cells grown in vitro. Am. J. Physiol. 244: C227-C233, 1983.
2. BARBER, R. AND BUTCHER, R. W.: The egress of cyclic AMP from metazoan cells. Adv. Cyclic Nucleotide Res. 15: 119-138, 1983.
3. CAMPBELL, W. B. AND JACKSON, E. K.: Modulation of adrenergic transmission by angiotensins in the perfused rat mesentery. Am. J. Physiol. 236: H211-H217, 1979.
4. COULSON, R. AND BOWMAN, R. H.: Excretion and degradation of exogenous adenosine 3′,5′-monophosphate by isolated perfused rat kidney. Life Sci. 14: 545-556, 1974.
5. COULSON, R., BOWMAN, R. H. AND ROCH-RAMEL, F.: The effects of nephrectomy and probenecid on in vivo clearance of adenosine-3′,5′-monophosphate from rat plasma. Life Sci. 15: 877-886, 1974.
6. CUNNINGHAM, R. F., ISRAILI, Z. H. AND DAYTON, P. G.: Clinical pharmacokinetics of probenecid. Clin. Pharmacokinet. 6: 135-151, 1981.
7. DUBEY, R. K., ROY, A., OVERBECK, H. W.: Culture of renal arteriolar smooth muscle cells. Mitogenic responses to angiotensin II. Circ. Res. 71: 1143-1152, 1992.
8. DUBEY, R. K., MI, Z., GILLESPIE, D. G. AND JACKSON, E. K.: Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth. Hypertension 28: 765-771, 1996.
9. GOGEL, E., HALLORAN, B. P. AND STREWLER, G. J.: Probenecid inhibits the secretion of nephrogenous adenosine 3′,5′-monophosphate in normal man. J. Clin. Endocrinol. Metab. 57: 689-693, 1983.
10. GORDON, E. L., PEARSON, J. D., DICKINSON, E. S., MOREAU, D. AND SLAKEY, L. L.: The hydrolysis of extracellular adenine nucleotides by arterial smooth muscle cells. Regulation of adenosine production at the cell surface. J. Biol. Chem. 264: 18986-18995, 1989.
11. GORDON, E. L., PEARSON, J. D. AND SLAKEY, L. L.: The hydrolysis of extracellular adenine nucleotides by cultured endothelial cells form pig aorta. Feed-forward inhibition of adenosine production at the cell surface. J. Biol. Chem. 261: 15496-15507, 1986.
12. JACKSON, E. K.: Adenosine: A physiological brake on renin release. Annu. Rev. Pharmacol. Toxicol. 31: 1-35, 1991.
13. JACKSON, E. K.: Renal actions of purines. In Purinergic Approaches in Experimental Therapeutics, ed. by K. A. Jacobson and M. F. Jarvis, Wiley-Liss, New York, NY, pp. 217-250, 1997.
14. JACKSON, E. K. AND CAMPBELL, W. B.: Inhibition of angiotensin II potentiation of sympathetic nerve activity by beta-adrenergic antagonists. Hypertension 2: 90-96, 1980.
15. JACKSON, E. K., MI, Z., KOEHLER, M. T., CARCILLO, J. A., JR. AND HERZER, W. A.: Injured erythrocytes release adenosine deaminase into the circulation, J. Pharmacol. Exp. Ther. 279: 1250-1260, 1996.
16. LE HIR, M. L. AND KAISSLING, B.: Distribution and regulation of renal ecto-5′-nucleotidase: implications for physiological functions of adenosine. Am. J. Physiol. 264: F377-F387, 1993.
17. MCGREGOR, D. D.: The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat. J. Physiol. 177: 21-30, 1965.
18. MI, Z., HERZER, W. A., ZHANG, Y. AND JACKSON, E. K.: 3-Isobutyl-1-methylxanthine decreases renal cortical interstitial levels of adenosine and inosine. Life Sci. 54: PL-277-PL-282, 1994.
19. MI, Z. AND JACKSON, E. K.: Metabolism of exogenous cyclic AMP to adenosine in the rat kidney. J. Pharmacol. Exp. Ther. 273: 728-733, 1995.
20. MOLLER, J. V. AND SHEIKH, M. I.: Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol. Rev. 34: 315-358, 1982.
21. PODEVIN, R. A., BOUMENDIL-PODEVIN, E. F., BUJOLI-ROCHE, J. AND PRIOL, C.: Effects of probenecid on transport and metabolism of cyclic AMP by isolated rabbit renal tubules. Biochim. Biophys. Acta 629: 135-142, 1980.
22. STEFANOVIC, V., SAVIC, V., VLAHOVIC, P., ARDAILLOU, N. AND ARDAILLOU, R.: Macrophages selectively stimulate ecto-5′-nucleotidase activity of cultured mesangial cells. Kidney Int. 36: 249-256, 1989.
23. ULLRICH, K. J., RUMRICH, G., PAPAVASSILIOU, F., KLOSS, S. AND FRITZSCH, G.: Contraluminal p-aminohippurate transport in the proximal tubule of the kidney. VII. Specificity: cyclic nucleotides, eicosanoids. Pflugers Arch. Eur. J. Physiol. 418: 360-370, 1991.