GnRH inhibits neuronal activity in the ventral tegmental area of the estrogen-primed ovariectomized rat

Neuroscience Letters

Volumn 228, Issue 1, 1997, Pages 13-16

  Suga, Sechiko ^a   Akaishi, Takao ^b   Sakuma, Yasuo ^c  

^a HIROSAKI UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Estrogen; Gonadotropin releasing hormone; Gonadotropin releasing hormone analog; Lordosis reflex; Microiontophoresis; Ventral tegmental area

Indexed keywords

ESTROGEN; GONADORELIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; GONADOTROPIN RELEASE; NERVE CONDUCTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VENTRAL TEGMENTUM;

ANIMALS; ESTROGENS; FEMALE; GONADOTROPIN-RELEASING HORMONE; NEURAL INHIBITION; NEURONS; OVARIECTOMY; RATS; RATS, WISTAR; SEXUAL BEHAVIOR, ANIMAL; TEGMENTUM MESENCEPHALI;

EID: 0030855636     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00348-0     Document Type: Article

References (20)

1. Badr, M., Marchetti, B. and Pelletier, G., Modulation of hippocampal LHRH receptors by sex steroids in the rat, Peptides, 9 (1988) 441-442.
2. Bauer-Dantoin, A.C., Weiss, J. and Jameson, J.L., Roles of estrogen, progesterone, and gonadotropin-releasing hormone (GnRH) in the control of pituitary GnRH receptor gene expression at the time of the preovulatory gonadotropin surges, Endocrinology, 136 (1995) 1014-1019.
3. Beckstead, R.M., Domesick, V.B. and Nauta, W.J., Efferent connections of the substantia nigra and ventral tegmental area in the rat, Brain Res., 175 (1979) 191-217.
4. Chen, Y., Wong, M. and Moss, R.L., Effects of a biologically active LHRH fragment on CA1 hippocampal neurons, Peptides, 14 (1993) 1079-1081.
5. Don Carlos, L.L., Monroy, E. and Morrell, J.I., Distribution of estrogen receptor-immunoreactive cells in the forebrain of the female guinea pig, J. Comp. Neurol., 305 (1991) 591-612.
6. Gargiulo, P.A. and Donoso, A.O., Interaction between glutamate and luteinizing hormone-releasing hormone (LHRH) in lordosis behavior and luteinizing hormone release (LH): further studies on NMDA receptor mediation, Physiol. Behav., 58 (1995) 169-173.
7. Hasegawa, T. and Sakuma, Y., Developmental effect of androgen on estrogen sensitivity of the rat preoptic neurons with axons to the ventral midbrain, Brain Res., 611 (1993) 1-6.
8. Hasegawa, T., Takeo, T., Akitsu, H., Hoshina, Y. and Sakuma, Y., Interruption of the lordosis reflex of female rats by ventral midbrain stimulation, Physiol. Behav., 50 (1991) 1033-1038.
9. Jennes, L. and Conn, P.M., Gonadotropin-releasing hormone and its receptors in rat brain, Front. Neuroendocrinol., 15 (1994) 51-77.
10. 2+ concentration without inducing gonadotropin secretion, Mol. Endocrmol., 4 (1990) 678-684.
11. McArdle, C.A., Schomerus, E., Groner, I. and Poch, A., Estradiol regulates gonadotropin-releasing hormone receptor number, growth and inositol phosphate production in αT3-1 cells, Mol. Cell. Endocrinol., 87 (1992) 95-103.
12. A receptor activation enhances, and blockade reduces, sexual behavior in the female rat, Exp. Brain Res., 86 (1991) 108-116.
13. Merchenthaler, I., Gores, T., Sétâlo, G., Petrusz, P. and Flerkó, B., Gonadotropin-releasing hormone (GnRH) neurons and pathways in the rat brain, Cell Tissue Res., 237 (1984) 15-29.
14. Sakamoto, Y., Suga, S. and Sakuma, Y., Estrogen-sensitive neurons in the female rat ventral tegmental area: a dual route for the hormone action, J. Neurophysiol., 70 (1993) 1469-1475.
15. Sakuma, Y. and Pfaff, D.W., Modulation of the lordosis reflex of female rats by LHRH, its antiserum and analogs in the mesencephaHc central gray, Neuroendocrinology, 36 (1983) 218-224.
16. Shivers, B.D., Harlan, R.E., Morrell, J.I. and Pfaff, D.W., Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurons, Nature, 304 (1983) 345-347.
17. Schiess, M.C., Dudley, C.A. and Moss, R.L., Estrogen priming affects the sensitivity of midbrain central gray neurons to microiontophoretically applied LHRH but not β-endorphin, Neuroendocrinology, 46 (1987) 24-31.
18. Sirinathsinghji, D.J.S., Whittington, P.E. and Audsley, A.R., Regulation of mating behaviour in the female rat by gonadotropin-releasing hormone in the ventral tegmental area: effects of selective destruction of the AlO dopamine neurones, Brain Res., 374 (1986) 167-173.
19. Takeo, T., Chiba, Y. and Sakuma, Y., Suppression of the lordosis reflex of female rats by efferents of the medial preoptic area, Physiol. Behav., 53 (1993) 831-838.
20. Zadina, J.E., Kastin, A.J., Fabre, L.A. and Coy, D.H., Facilitation of sexual receptivity in the rat by an ovulation-inhibiting analog of LHRH, Pharmacol. Biochem. Behav., 15 (1981) 961-964.