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Volumn 16, Issue 14, 1997, Pages 4421-4432

Identification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing

Author keywords

3' splice site; Mammalian pre mRNA splicing; Protein splicing factors; Second step of splicing; UV crosslinking

Indexed keywords

DINUCLEOTIDE; MESSENGER RNA PRECURSOR; POLYPEPTIDE; PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

EID: 0030855063     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.14.4421     Document Type: Article
Times cited : (45)

References (65)
  • 1
    • 0344142407 scopus 로고
    • Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
    • Abmayr, S.M., Reed, R. and Manatis, T. (1988) Identification of a functional mammalian spliceosome containing unspliced pre-mRNA. Proc. Natl Acad. Sci. USA, 85, 7216-7220.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 7216-7220
    • Abmayr, S.M.1    Reed, R.2    Manatis, T.3
  • 2
    • 0022974809 scopus 로고
    • Sequence requirements for splicing of higher eukaryotic nuclear premRNA
    • Aebi, M. Hornig, H., Padgett, R.A., Reiser, J. and Weissmann, C. (1986) Sequence requirements for splicing of higher eukaryotic nuclear premRNA. Cell, 47, 555-565.
    • (1986) Cell , vol.47 , pp. 555-565
    • Aebi, M.1    Hornig, H.2    Padgett, R.A.3    Reiser, J.4    Weissmann, C.5
  • 3
    • 0023658298 scopus 로고
    • 5′ Cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU
    • Aebi, M., Hornig, M. and Weissmann, C. (1987) 5′ Cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU. Cell, 50, 237-246.
    • (1987) Cell , vol.50 , pp. 237-246
    • Aebi, M.1    Hornig, M.2    Weissmann, C.3
  • 4
    • 0026661948 scopus 로고
    • Protein components specifically associated with prespliceosome and spliceosome complexes
    • Bennett, M., Michaud, S., Kingston, J. and Reed, R. (1992) Protein components specifically associated with prespliceosome and spliceosome complexes. Genes Dev., 6, 1986-2000.
    • (1992) Genes Dev. , vol.6 , pp. 1986-2000
    • Bennett, M.1    Michaud, S.2    Kingston, J.3    Reed, R.4
  • 5
    • 0020036471 scopus 로고
    • Anti-RNP monoclonal antibodies derived from a mouse strain with lupus-like autoimmunity
    • Billings, P.B., Allen, R.W., Jensen, F.C. and Hoch, S.O. (1982) Anti-RNP monoclonal antibodies derived from a mouse strain with lupus-like autoimmunity. J. Immunol., 128, 1176-1180.
    • (1982) J. Immunol. , vol.128 , pp. 1176-1180
    • Billings, P.B.1    Allen, R.W.2    Jensen, F.C.3    Hoch, S.O.4
  • 6
    • 0027440306 scopus 로고
    • Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9
    • Brosi, R., Groning, K., Behrens, S.-E., Luhrmann, R. and Kramer, A. (1993) Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9. Science, 262, 102-104.
    • (1993) Science , vol.262 , pp. 102-104
    • Brosi, R.1    Groning, K.2    Behrens, S.-E.3    Luhrmann, R.4    Kramer, A.5
  • 7
    • 0029894931 scopus 로고    scopus 로고
    • Identification of proteins that interact with exon sequences, splice site, and the branchpoint sequence during each stage of spliceosome assembly
    • Chiara, D., Gozani, O., Bennett, M., Champion-Arnaud, P., Palandjian, L. and Reed, R. (1996) Identification of proteins that interact with exon sequences, splice site, and the branchpoint sequence during each stage of spliceosome assembly. Mol. Cell. Biol., 16, 3317-3326.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3317-3326
    • Chiara, D.1    Gozani, O.2    Bennett, M.3    Champion-Arnaud, P.4    Palandjian, L.5    Reed, R.6
  • 8
    • 0026440183 scopus 로고
    • An essential splicing factor, SLU7, mediates 3′ splice site choice in yeast
    • Frank, D. and Guthrie, C. (1992) An essential splicing factor, SLU7, mediates 3′ splice site choice in yeast. Genes Dev., 6, 2112-2124.
    • (1992) Genes Dev. , vol.6 , pp. 2112-2124
    • Frank, D.1    Guthrie, C.2
  • 9
    • 0024842159 scopus 로고
    • Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns
    • Garcia-Blanco, M.A., Jamison, S.F. and Sharp, P.A. (1989) Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes Dev., 3, 1874-1886.
    • (1989) Genes Dev. , vol.3 , pp. 1874-1886
    • Garcia-Blanco, M.A.1    Jamison, S.F.2    Sharp, P.A.3
  • 10
    • 0029312249 scopus 로고
    • Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein
    • Gaur, R.K., Valcarcel, J. and Green, M.R. (1995) Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein. RNA, 1, 407-417.
    • (1995) RNA , vol.1 , pp. 407-417
    • Gaur, R.K.1    Valcarcel, J.2    Green, M.R.3
  • 11
    • 0022869672 scopus 로고
    • A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA
    • Gerke, V. and Steitz, J.A. (1986) A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA. Cell, 47, 973-984.
    • (1986) Cell , vol.47 , pp. 973-984
    • Gerke, V.1    Steitz, J.A.2
  • 12
    • 0028360767 scopus 로고
    • A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction
    • Gozani, O., Patton, J.G. and Reed, R. (1994) A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J., 13, 3356-3367.
    • (1994) EMBO J. , vol.13 , pp. 3356-3367
    • Gozani, O.1    Patton, J.G.2    Reed, R.3
  • 13
    • 0025787954 scopus 로고
    • Biochemical mechanisms of constitutive and regulated pre-mRNA splicing
    • Green, M.R. (1991) Biochemical mechanisms of constitutive and regulated pre-mRNA splicing. Annu. Rev. Cell Biol., 7, 559-599.
    • (1991) Annu. Rev. Cell Biol. , vol.7 , pp. 559-599
    • Green, M.R.1
  • 14
    • 0026423013 scopus 로고
    • Messenger RNA splicing in yeast: Clues to why the spliceosome is a ribonucleoprotein
    • Guthrie, C. (1991) Messenger RNA splicing in yeast: clues to why the spliceosome is a ribonucleoprotein. Science, 253, 157-163.
    • (1991) Science , vol.253 , pp. 157-163
    • Guthrie, C.1
  • 15
    • 0027972301 scopus 로고
    • A 69-kD protein that associates reversibly with the Sm core domain of several spliceosomal snRNP species
    • Hackl, W., Fischer, U. and Luhrmann, R. (1994) A 69-kD protein that associates reversibly with the Sm core domain of several spliceosomal snRNP species. J. Cell Biol., 124, 261-272.
    • (1994) J. Cell Biol. , vol.124 , pp. 261-272
    • Hackl, W.1    Fischer, U.2    Luhrmann, R.3
  • 16
    • 0027923620 scopus 로고
    • Role of U6 snRNA in 5′ splice site selection
    • Kandel-Lewis, S. and Seraphin, B. (1993) Role of U6 snRNA in 5′ splice site selection. Science, 262, 2035-2039.
    • (1993) Science , vol.262 , pp. 2035-2039
    • Kandel-Lewis, S.1    Seraphin, B.2
  • 17
    • 0027761185 scopus 로고
    • Disruption of base pairing between the 5′ splice site and the 5′ end of U1 snRNA is required for spliceosome assembly
    • Konforti, B.B., Koziolkiewicz, M.J. and Konarska, M.M. (1993) Disruption of base pairing between the 5′ splice site and the 5′ end of U1 snRNA is required for spliceosome assembly. Cell, 75, 863-873.
    • (1993) Cell , vol.75 , pp. 863-873
    • Konforti, B.B.1    Koziolkiewicz, M.J.2    Konarska, M.M.3
  • 18
    • 0022135603 scopus 로고
    • Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro
    • Krainer, A.R. and Maniatis, T. (1985) Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell, 42, 725-736.
    • (1985) Cell , vol.42 , pp. 725-736
    • Krainer, A.R.1    Maniatis, T.2
  • 19
    • 0029891101 scopus 로고    scopus 로고
    • The structure and function of proteins involved in mammalian pre-mRNA splicing
    • Kramer, A. (1996) The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem., 65, 367-409.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 367-409
    • Kramer, A.1
  • 20
    • 0027278703 scopus 로고
    • Non-snRNP protein splicing factors
    • Lamm, G.M. and Lamond, A.I. (1993) Non-snRNP protein splicing factors. Biochim. Biophys. Acta, 1173, 247-265.
    • (1993) Biochim. Biophys. Acta , vol.1173 , pp. 247-265
    • Lamm, G.M.1    Lamond, A.I.2
  • 21
    • 0023390960 scopus 로고
    • A mutational analysis of spliceosome assembly: Evidence for splice site collaboration during spliceosome formation
    • Lamond, A.I., Konarska, M.M. and Sharp, P.A. (1987) A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation. Genes Dev., 1, 532-543.
    • (1987) Genes Dev. , vol.1 , pp. 532-543
    • Lamond, A.I.1    Konarska, M.M.2    Sharp, P.A.3
  • 22
    • 0027739852 scopus 로고
    • Mutations in U6 snRNA that alter splice site specificity: Implications for the active site
    • Lesser, C.F. and Guthrie, C. (1993) Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science, 262, 1982-1988.
    • (1993) Science , vol.262 , pp. 1982-1988
    • Lesser, C.F.1    Guthrie, C.2
  • 23
    • 0028556367 scopus 로고
    • Dynamic RNA-RNA interactions in the spliceosome
    • Madhani, H.D. and Guthrie, C. (1994) Dynamic RNA-RNA interactions in the spliceosome. Annu. Rev. Genet., 28, 1-26.
    • (1994) Annu. Rev. Genet. , vol.28 , pp. 1-26
    • Madhani, H.D.1    Guthrie, C.2
  • 24
    • 0023651444 scopus 로고
    • Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
    • Milligan, J.F., Groebe, D.R., Witherell, G.W. and Uhlenbeck, O.C. (1987) Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res., 15, 8783-8798.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8783-8798
    • Milligan, J.F.1    Groebe, D.R.2    Witherell, G.W.3    Uhlenbeck, O.C.4
  • 25
    • 0027184339 scopus 로고
    • Chemical Cleveland mapping: A rapid technique for characterization of crosslinked nucleic acid-protein complexes
    • Mirfakhrai, M. and Weiner, A.M. (1993) Chemical Cleveland mapping: a rapid technique for characterization of crosslinked nucleic acid-protein complexes. Nucleic Acids Res., 21, 3591-3592.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3591-3592
    • Mirfakhrai, M.1    Weiner, A.M.2
  • 26
    • 0026680843 scopus 로고
    • Site-specific modification of pre-mRNA: The 2′ hydroxyl groups at the splice sites
    • Moore, M.J. and Sharp, P.A. (1992) Site-specific modification of pre-mRNA: the 2′ hydroxyl groups at the splice sites. Science, 256, 992-997.
    • (1992) Science , vol.256 , pp. 992-997
    • Moore, M.J.1    Sharp, P.A.2
  • 27
    • 0001877802 scopus 로고
    • Splicing of precursors to messenger RNAs by the spliceosome
    • Gestland, R.I. and Atkins, J.F. (eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Moore, M.J., Query, C.C. and Sharp, P.A. (1993) Splicing of precursors to messenger RNAs by the spliceosome. In Gestland, R.I. and Atkins, J.F. (eds), The RNA World. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 1-30.
    • (1993) The RNA World , pp. 1-30
    • Moore, M.J.1    Query, C.C.2    Sharp, P.A.3
  • 28
    • 0028308696 scopus 로고
    • RNA-RNA interactions in the spliceosome: Unraveling the ties that bind
    • Neilsen, T.W. (1994) RNA-RNA interactions in the spliceosome: unraveling the ties that bind. Cell, 78, 1-4.
    • (1994) Cell , vol.78 , pp. 1-4
    • Neilsen, T.W.1
  • 29
    • 0022384478 scopus 로고
    • Molecular consequence of specific intron mutations on yeast mRNA splicing in vivo and in vitro
    • Newman, A.J., Lin, R., Cheng, S. and Abelson, J. (1985) Molecular consequence of specific intron mutations on yeast mRNA splicing in vivo and in vitro. Cell, 42, 335-344.
    • (1985) Cell , vol.42 , pp. 335-344
    • Newman, A.J.1    Lin, R.2    Cheng, S.3    Abelson, J.4
  • 30
    • 0027408848 scopus 로고
    • Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron
    • Parker, R. and Siliciano, P.G. (1993) Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron. Nature, 361, 660-662.
    • (1993) Nature , vol.361 , pp. 660-662
    • Parker, R.1    Siliciano, P.G.2
  • 31
    • 0023663370 scopus 로고
    • Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA
    • Parker, R., Siliciano, P.G. and Guthrie, C. (1987) Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell, 49, 229-239.
    • (1987) Cell , vol.49 , pp. 229-239
    • Parker, R.1    Siliciano, P.G.2    Guthrie, C.3
  • 32
    • 0027245959 scopus 로고
    • Cloning and characterization of PSF, a novel pre-mRNA splicing factor
    • Patton, J.G., Porro, E.B., Galceran, J., Tempst, P. and Nadal-Ginord, B. (1993) Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev., 7, 393-406.
    • (1993) Genes Dev. , vol.7 , pp. 393-406
    • Patton, J.G.1    Porro, E.B.2    Galceran, J.3    Tempst, P.4    Nadal-Ginord, B.5
  • 33
    • 0024603237 scopus 로고
    • A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein
    • Query, C.C., Bentley, R.C. and Keene, J.D. (1989) A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell, 57, 89-101.
    • (1989) Cell , vol.57 , pp. 89-101
    • Query, C.C.1    Bentley, R.C.2    Keene, J.D.3
  • 34
    • 0024808994 scopus 로고
    • The organization of 3′ splice-site sequences in mammalian introns
    • Reed, R. (1989) The organization of 3′ splice-site sequences in mammalian introns. Genes Dev., 3, 2113-2123.
    • (1989) Genes Dev. , vol.3 , pp. 2113-2123
    • Reed, R.1
  • 35
    • 0021887989 scopus 로고
    • Intron sequences involved in lariat formation during pre-mRNA splicing
    • Reed, R. and Maniatis, T. (1985) Intron sequences involved in lariat formation during pre-mRNA splicing. Cell, 41, 95-105.
    • (1985) Cell , vol.41 , pp. 95-105
    • Reed, R.1    Maniatis, T.2
  • 36
    • 0024290434 scopus 로고
    • Purification and visualization of native spliceosomes
    • Reed, R., Griffith, J. and Maniatis, T. (1988) Purification and visualization of native spliceosomes. Cell, 53, 949-961.
    • (1988) Cell , vol.53 , pp. 949-961
    • Reed, R.1    Griffith, J.2    Maniatis, T.3
  • 37
    • 0023007277 scopus 로고
    • Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies
    • Reuter, R. and Luhrmann, R. (1986) Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies. Proc. Natl Acad. Sci. USA, 83, 8689-8693.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 8689-8693
    • Reuter, R.1    Luhrmann, R.2
  • 38
    • 0023834880 scopus 로고
    • A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly
    • Ruskin, E., Zamore, P.D. and Green, M.R. (1988) A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell, 52, 207-219.
    • (1988) Cell , vol.52 , pp. 207-219
    • Ruskin, E.1    Zamore, P.D.2    Green, M.R.3
  • 39
    • 0026453396 scopus 로고
    • Evidence for a base-pairing interaction between U6 small nuclear RNA and the 5′ splice site during the splicing reaction in yeast
    • Sawa, H. and Abelson, J. (1992) Evidence for a base-pairing interaction between U6 small nuclear RNA and the 5′ splice site during the splicing reaction in yeast. Proc. Natl Acad. Sci. USA, 89, 11269-11273.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 11269-11273
    • Sawa, H.1    Abelson, J.2
  • 40
    • 0025742772 scopus 로고
    • Alterations of RNase H sensitivity of the 3′ splice site region during the in vitro splicing reaction
    • Sawa, H. and Shimura, Y. (1991) Alterations of RNase H sensitivity of the 3′ splice site region during the in vitro splicing reaction. Nucleic Acids Res., 19, 3953-3958.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 3953-3958
    • Sawa, H.1    Shimura, Y.2
  • 41
    • 0026524532 scopus 로고
    • Association of U6 snRNA with the 5′-splice site region of pre-mRNA in the spliceosome
    • Sawa, H. and Shimura, Y. (1992) Association of U6 snRNA with the 5′-splice site region of pre-mRNA in the spliceosome. Genes Dev., 6, 244-254.
    • (1992) Genes Dev. , vol.6 , pp. 244-254
    • Sawa, H.1    Shimura, Y.2
  • 42
    • 0027065506 scopus 로고
    • A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis
    • Schwer, B. and Guthrie, C. (1992) A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J., 11, 5033-5039.
    • (1992) EMBO J. , vol.11 , pp. 5033-5039
    • Schwer, B.1    Guthrie, C.2
  • 43
    • 0025087346 scopus 로고
    • Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing
    • Seraphin, B. and Rosbash, M. (1990) Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing. Cell, 63, 619-629.
    • (1990) Cell , vol.63 , pp. 619-629
    • Seraphin, B.1    Rosbash, M.2
  • 44
    • 0024062611 scopus 로고
    • A U1 snRNA:pre-mRNA base-pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site
    • Seraphin, B., Kretzner, L. and Rosbash, M. (1988) A U1 snRNA:pre-mRNA base-pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site. EMBO J., 7, 2533-2538.
    • (1988) EMBO J. , vol.7 , pp. 2533-2538
    • Seraphin, B.1    Kretzner, L.2    Rosbash, M.3
  • 45
    • 0024100924 scopus 로고
    • 5′ Splice site selection in yeast: Genetic alterations in base-pairing with U1 reveal additional requirements
    • Siliciano, P.G. and Guthrie, C. (1988) 5′ Splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev., 2, 1258-1267.
    • (1988) Genes Dev. , vol.2 , pp. 1258-1267
    • Siliciano, P.G.1    Guthrie, C.2
  • 46
    • 0029055472 scopus 로고
    • Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
    • Singh, R., Valcarcel, J. and Green, M.R. (1995) Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science, 268, 1173-1176.
    • (1995) Science , vol.268 , pp. 1173-1176
    • Singh, R.1    Valcarcel, J.2    Green, M.R.3
  • 47
    • 0024470631 scopus 로고
    • Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns
    • Smith, C.W.J., Porro, E.B., Patton, J.G. and Nadal-Ginard, B. (1989) Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns. Nature, 342, 243-247.
    • (1989) Nature , vol.342 , pp. 243-247
    • Smith, C.W.J.1    Porro, E.B.2    Patton, J.G.3    Nadal-Ginard, B.4
  • 48
    • 0027739853 scopus 로고
    • The U5 and U6 small nuclear RNAs as active site components of the spliceosome
    • Sontheimer, E. and Steitz, J.A. (1993) The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science, 262, 1989-1995.
    • (1993) Science , vol.262 , pp. 1989-1995
    • Sontheimer, E.1    Steitz, J.A.2
  • 49
    • 0023603553 scopus 로고
    • The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding
    • Spritz, R.A., Strunk, K., Surowy, C.S., Hoch, S.O., Barton, D.E. and Franke, U. (1987) The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding. Nucleic Acids Res., 15, 10373-10391.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 10373-10391
    • Spritz, R.A.1    Strunk, K.2    Surowy, C.S.3    Hoch, S.O.4    Barton, D.E.5    Franke, U.6
  • 50
    • 0028006713 scopus 로고
    • Direct interactions between pre-mRNA and six U2 small ribonucleoproteins during spliceosome assembly
    • Staknis, D. and Reed, R. (1994) Direct interactions between pre-mRNA and six U2 small ribonucleoproteins during spliceosome assembly. Mol. Cell. Biol., 14, 7670-7682.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7670-7682
    • Staknis, D.1    Reed, R.2
  • 51
    • 0028825765 scopus 로고
    • Members of a family of proteins (the RD family) detected by a U1-70K monoclonal antibody are present in spliceosomal complexes
    • Staknis, D. and Reed, R. (1995) Members of a family of proteins (the RD family) detected by a U1-70K monoclonal antibody are present in spliceosomal complexes. Nucleic Acids Res., 23, 4081-4086.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 4081-4086
    • Staknis, D.1    Reed, R.2
  • 52
    • 0022894691 scopus 로고
    • A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein
    • Tazi, J., Alibert, C., Temsamani, J., Reveilland, I., Cathala, G., Brunel, C. and Jeanteur, P. (1986) A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein. Cell, 47, 755-766.
    • (1986) Cell , vol.47 , pp. 755-766
    • Tazi, J.1    Alibert, C.2    Temsamani, J.3    Reveilland, I.4    Cathala, G.5    Brunel, C.6    Jeanteur, P.7
  • 53
    • 0029031713 scopus 로고
    • Extensive interactions of PRP8 protein with the 5′ and 3′ splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA
    • Teigelkamp, S., Newman, A.J. and Beggs, J.D. (1995a) Extensive interactions of PRP8 protein with the 5′ and 3′ splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA. EMBO J., 14, 2602-2612.
    • (1995) EMBO J. , vol.14 , pp. 2602-2612
    • Teigelkamp, S.1    Newman, A.J.2    Beggs, J.D.3
  • 54
    • 0028923647 scopus 로고
    • Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing
    • Teigelkamp, S., Whittaker, E. and Beggs, J.D. (1995b) Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing. Nucleic Acids Res., 23, 320-326.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 320-326
    • Teigelkamp, S.1    Whittaker, E.2    Beggs, J.D.3
  • 55
    • 0029349060 scopus 로고
    • Prp16p, Slu7p, and Prp8p interact with the 3′ splice site in two distinct stages during the second catalytic step of pre-mRNA splicing
    • Umen, J.G. and Guthrie,C. (1995a) Prp16p, Slu7p, and Prp8p interact with the 3′ splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. RNA, 1, 584-597.
    • (1995) RNA , vol.1 , pp. 584-597
    • Umen, J.G.1    Guthrie, C.2
  • 56
    • 0028960809 scopus 로고
    • A novel role for a U5 snRNP protein in 3′ splice site selection
    • Umen, J.G. and Guthrie, C. (1995b) A novel role for a U5 snRNP protein in 3′ splice site selection. Genes Dev., 9, 855-868.
    • (1995) Genes Dev. , vol.9 , pp. 855-868
    • Umen, J.G.1    Guthrie, C.2
  • 57
    • 0029397324 scopus 로고
    • The second catalytic step of pre-mRNA splicing
    • Umen, J.G. and Guthrie, C. (1995c) The second catalytic step of pre-mRNA splicing. RNA, 1, 869-885.
    • (1995) RNA , vol.1 , pp. 869-885
    • Umen, J.G.1    Guthrie, C.2
  • 58
    • 0026670431 scopus 로고
    • Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing
    • Wassarman, D.A. and Steitz, J.A. (1992) Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing. Science, 257, 1918-1925.
    • (1992) Science , vol.257 , pp. 1918-1925
    • Wassarman, D.A.1    Steitz, J.A.2
  • 59
    • 0024743838 scopus 로고
    • Mammalian pre-mRNA branch site selection by U2 snRNP involves base-pairing
    • Wu, J. and Manley, J.L. (1989) Mammalian pre-mRNA branch site selection by U2 snRNP involves base-pairing. Genes Dev., 3, 1553-1561.
    • (1989) Genes Dev. , vol.3 , pp. 1553-1561
    • Wu, J.1    Manley, J.L.2
  • 60
    • 0027059033 scopus 로고
    • Site-specific cross-linking of mammalian U5 snRNP to the 5′ splice site before the first step of pre-mRNA splicing
    • Wyatt, J.R., Sontheimer, E.J. and Steitz, J.A. (1992) Site-specific cross-linking of mammalian U5 snRNP to the 5′ splice site before the first step of pre-mRNA splicing. Genes Dev., 6, 2542-2553.
    • (1992) Genes Dev. , vol.6 , pp. 2542-2553
    • Wyatt, J.R.1    Sontheimer, E.J.2    Steitz, J.A.3
  • 61
    • 0026026981 scopus 로고
    • Biochemical characterization of U2 snRNP auxiliary factor: An essential pre-mRNA splicing factor with a novel intranuclear distribution
    • Zamore, P.D. and Green, M.R. (1991) Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. EMBO J., 10, 207-214.
    • (1991) EMBO J. , vol.10 , pp. 207-214
    • Zamore, P.D.1    Green, M.R.2
  • 62
    • 0022550119 scopus 로고
    • A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation
    • Zhuang, Y. and Weiner, A.M. (1986) A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation. Cell, 46, 827-835.
    • (1986) Cell , vol.46 , pp. 827-835
    • Zhuang, Y.1    Weiner, A.M.2
  • 63
    • 0024744567 scopus 로고
    • A compensatory base change in human U2 snRNA can suppress a branch site mutation
    • Zhuang, Y. and Weiner, A.M. (1989) A compensatory base change in human U2 snRNA can suppress a branch site mutation. Genes Dev., 3, 1545.
    • (1989) Genes Dev. , vol.3 , pp. 1545
    • Zhuang, Y.1    Weiner, A.M.2
  • 64
    • 0025076272 scopus 로고
    • The conserved dinucleotide AG of the 3′ splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors
    • Zhuang, Y. and Weiner, A.M. (1990) The conserved dinucleotide AG of the 3′ splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors. Gene, 90, 263-269.
    • (1990) Gene , vol.90 , pp. 263-269
    • Zhuang, Y.1    Weiner, A.M.2
  • 65
    • 0023845346 scopus 로고
    • Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles
    • Zillmann, M., Zapp, M.L. and Berget, S.M. (1988) Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles. Mol. Cell. Biol., 8, 814-821.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 814-821
    • Zillmann, M.1    Zapp, M.L.2    Berget, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.