Major human cancers are preventable: Physiological stimuli induce a dopamine-thyroid-immune efficient mechanism

European Journal of Cancer Prevention

Volumn 6, Issue 3, 1997, Pages 269-276

  Gilbert, C ^a  

^a Francis Court ^*  (Cyprus)

Author keywords

Cancer prevention; Dopamine and immunity; Hormones and immunity; Neurotransmitters and immunity

Indexed keywords

ARTICLE; CANCER; CANCER RISK; DOPAMINERGIC NERVE CELL; HUMAN; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; IMMUNE SYSTEM; PRIORITY JOURNAL; TUMOR IMMUNITY;

DOPAMINE; FEMALE; HUMANS; MALE; NEOPLASMS; PREGNANCY; RISK FACTORS; THYROID GLAND; UP-REGULATION;

EID: 0030854344     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Aldercreutz H, Markkanen H, Watanabe S (1993). Plasma concentrations of phyto-oestrogens in Japanese men. Lancer 342: 1209-12.
2. Aoki K, Tominaga S, Hira T (1984). Cancer Prevention in Developing Countries. Nagoya Press. Nagoya.
3. Balsam A, Leppo LE (1975). Effect of physical training on the metabolism of thyroid hormones in man. J Appl Physiol 38: 212.
4. Berczi I (1994). Hormonal interactions between the pituitary and immune system. In Bilateral Communications between the Endocrine and Immune Systems (ed Grossman CJ); Springer-Verlag, New York, pp. 96-114.
5. Bianchine JR (1980). Clinical correlates of changes in receptors during aging. Parkinson's - a striatal dopamine deficiency syndrome. In Modern Aging Research I: Neuroregulatory Mechanisms During Aging (eds Adelman RC, Baker CT, Baskins I, Cristofalo VJ): Liss, New York, pp. 129-41.
6. Boyle P, Maisonneuve P, Doré JF (1995). Epidemiology of malignant melanoma. In Melanoma (ed Mackie RM). Br Med Bull 51: 523-47.
7. Burch JC, Byrd BF, Vaughn WK (1975). The effects of long-term estrogen administration to women following hysterectomy. In Estrogens in the Post-menopause (eds van Keep P, Lauritzen C); (In the series Frontiers in Hormonal Research), Karger, Basel, pp. 208-14.
8. Cancer Prevention Study Group (ATBC) (1994). The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330: 141-7.
9. Coetzer P, Noakes TD, Sanders B et al (1993). Superior fatigue resistance of élite black South African distance runners. Am Physiol Soc 75: 1822-7.
10. Colbourn DS, Nathanson L, Beliles E (1989). Pregnancy and malignant melanoma. Semin Oncol 161: 379-87.
11. Del Rey A, Besedowsky HG (1987). Immune-neuroendocrine feedback regulatory signals. In Hormones and Immunity (eds Berczi I, Kovacs K): MTP Press, UK, pp. 215-30.
12. Di Chiara G, Acquas E, Carhoni E (1990). Dopamine and drug-induced activation. In Advances in the Biosciences (eds Gessa GL, Serra G); Oxford University Press, Oxford, pp. 27-37.
13. Falck B, Owman CH (1969). 5-Hydroxytryptamine and related amines in endocrine cell systems. Advances Pharmacol 6: 211-31.
14. Fernandez E, La Vecchia C, D'Aranzo B et al (1996). Oral contraceptive hormone replacement therapy and the risk of colorectal cancer. Br J Cancer 73: 1431-5.
15. Fraser GE, Singh P, Bennett H (1996). Variables associated with cognitive function in elderly Californian Seventh Day Adventists. Am J Epidemiol 143: 1181-90.
16. Fuxe K, Hökfelt T, Nilsson O (1969). Factors involved in the control of the activity of the tuberoinfundibular dopamine neurons during pregnancy and lactation. Neuroendocrinology 5: 257-70.
17. Galkina OV, Al'perina EL, Podogornaia EK, Devoino LV (1990). Changes in the level of dopamine and its metabolites in brain structure and immunocompetent organs in the formation of immune responses. Bull Eksp Biol Med 110: 66-9.
18. Garland CF, Garland FC, Shaw E et al (1989). Serum 25-hydroxyvitamin D and colon cancer: eight year prospective study. Lancet 334: 1178-8.
19. Gilbert C (1984). Endemic goitre. The cassava factor. World Health Forum 5: 170-4.
20. Gilbert C (1993). Low risk to certain diseases of aging: role of the autonomic nervous system and calcium metabolism. Mech Aging Dev 70: 95-113.
21. Gilbert C (1994). Neurotransmitter status and remission of rheumatoid arthritis in pregnancy. J Rheumatol 21: 1061-4.
22. Gilbert C (1995). Optimal physical performance in athletes: key roles of dopamine in a specific neurotransmitter/hormonal mechanism. Mech Aging Dev 84: 83-102.
23. Gillum RF, Mussolino ME, Ingram DD (1996). Physical activity and stroke incidence in women and men. Am J Epidemiol 143: 960-9.
24. Goedde WH (1986). Ethnic differences in reactions to drugs and other xenobiotics: outlook of a geneticist. In Ethnic Differences in Reactions to Drugs and Xenobiotics (eds Kalow W, Goedde WH, Agarwal DP): Liss, New York, pp. 9-20.
25. Grollman A, Grollman EF (1970). Pharmacology and Therapeutics 7th Ed, Lea and Febiger, Philadelphia, p. 270.
26. Heal DJ, Pycock CJ, Youdin MBH, Green AR (1983). Actions of TRH and its analogues on the mesolimboic dopamine system. In Thyrotropic Releasing Hormone (eds Griffiths EC, Bennett GW); Raven Press, New York, pp. 271-83.
27. 3 Syndrome (ed Hesch RD); Serono Symposia 40, pp. 233-41.
28. Hill P, Wynder E, Helman P et al (1976). Plasma hormone levels in different populations of women. Cancer Res 36: 2297-301.
29. Ingbar SJ (1985). The thyroid gland. In Williams Textbook of Endocrinology 7th Ed (eds Wilson JD, Foster DW); Saunders, Philadelphia, p. 706.
30. Jackson SHD, Bannan LT, Beevers DG (1981). Ethnic differences in respiratory diseases. Post Grad Med 57: 777-8.
31. Jodal M, Lundgren O (1983). Nerves to colon. In Colon Structure and Function (ed Bustos-Fernandez L); Plenum Press, New York, pp. 187-209.
32. Kelsey JL (1979). A review of the epidemiology of human breast cancer. Epidemiol Rev 1: 74-109.
33. Landsberg L, Young JB (1985). Catecholamines and the adrenal medulla. In Williams Textbook of Endocrinology 7th Ed (eds Wilson JD, Foster DW); Saunders, Philadelphia, pp. 944-5.
34. Lerner MR, Goldman RS (1987). Skin colour, MPTP and Parkinson's disease. Lancet 330: 212.
35. Leupold E (1945). Quoted by Theurer KE (1985). Chrono-biorhythymic theory. In Experimental and Clinical Studies with Xenogenic Peptides and Proteins (eds Gillissen G et al); Karger, pp. 1-8.
36. Lynch J, Helmrich SP, Lakka TA (1996). Moderately intense physical activity and high levels of cardiorespiratory fitness reduce the risk of non-insulin dependent diabetes in middle-aged men. Arch Int Med 156: 1307-13.
37. MacRae PG, Spirduso WW, Walters TJ, Farrar RP, Wilcox RE (1987). Endurance training effects on striatal D2 dopamine receptor binding and striatal dopamine metabolites in presenescent older rats. Psychopharmacology 92: 236-40.
38. Margulies PL, Imperato-McGinley J, Arthur A, Peterson RE (1983). Remission of Cushing's disease during pregnancy. Int J Gynaecol Obstet 21: 77-83.
39. Marmot MG, Davie-Smith G (1989). Why are the Japanese living longer? Br Med J 299: 1547-51.
40. Marsden CD (1987). Movement disorders. In Oxford Textbook of Medicine (eds Weatherall DJ, Ledingham JG, Warrell DA); Oxford University Press, pp. 21-219.
41. Miller RA (1995). Gerontology: the study of aging as the study of cancer. In Molecular Aspects of Aging (eds Esser K, Martin GM); Wiley. Chichester, pp. 265-78.
42. Miller RW (1978). Etiology - epidemiology. In Cancer in China (eds Kaplan HS, Tsuchitani PY); Liss, New York, pp. 39-57.
43. Mitchell MS (1989). Immunity to Cancer. II. Progress in Clinical and Biological Research. Liss, New York, Vol 288, p. 272.
44. Neff NH, HadJiconstantinou H (1987). In Progress in Catecholamine Research, Part A, Basic Aspects and Peripheral Mechanisms (eds Dahlstrom A, Belmaker BJ, Sandler M); Raven Press, New York, pp. 485-90.
45. Nelson JL, Steinberg AD (1987). Sex steroids and autonomic disease. In Hormones and Immunity (eds Berczi I, Kovacs K); MTP Press, Lancaster, pp. 107-12.
46. Nicholas NS, Panayi GS (1988). Rhematoid arthritis and pregnancy. Clin Exp Pharmacol 6: 179-82.
47. Nieman DC, Henson DA, Gusewitch G et al (1993). Physical activity and immune function in elderly women. Med Sci Sports Exercise 25: 823-31.
48. Peleg D, Arbugast L, Peleg E, Ben-Honathan N (1985). Catecholamines in maternal and fetal plasma and the amniotic fluid during late gestation in the rat. In Catecholamines as Hormonal Regulators (eds Ben-Jonathan N, Bohr JM, Weiner RT); Serono Symposia, Vol 18, Raven Press, New York, p. 350.
49. Perkins CM, Hancock RW, Cope GF, Lee MR (1981). Urine free dopamine in normal primigravid pregnancy and women taking oral contraceptives. Clin Sci 51: 423-8.
50. Piccardi MP, Martis G, Milas S, Corsini GU (1986). Down regulation of dopamine autoreceptors by oestrogen: physiological control. In Dopaminergic Systems and their Regulation (eds Woodruff GN, Poat JA, Roberts PJ); Macmillan, London, pp. 359-71.
51. Polak JM, Bishop AE, Bloom SR (1983). The regulatory peptides of the colon. In Colon Structure and Function (ed Bustos-Fernandiz L); Plenum Press, New York, pp. 167-86.
52. Potter HJD, Slattery ML, Bostick RM, Capstur SM (1993). Colon cancer: a review of the epidemiology. Epidemiol Rev 15: 499-545.
53. Ravid M, Lishner M, Zemlickis, Koren G (1996). Malignant melanoma and pregnancy. In Cancer in Pregnancy - Maternal and Fetal Risk (eds Koren G, Lishner M, Farine D); Cambridge University Press, Cambridge, pp. 134-41.
54. Riederer P, Sofic E, Konradi C et al (1989). The role of dopamine in the control of neurobiological functions. In The Role of Brain Dopamine (eds Flückiger E, Müller EE, Thorner MO); Springer-Verlag, Berlin, pp. 1-17.
55. Robuschi G, Safram M, Braverman LE, Gnudi A, Rati E (1987). Hypothyroidism in the elderly. Endocr Rev 8: 142-53.
56. Roth GS, Joseph JA (1994). Cellular and molecular mechanisms of impaired function during aging. Ann NY Acad Sci 719: 129-35.
57. Sawyer CJ (1979). Report: overview of session. IV. Interactions between hormones and neuro-transmitters in the control of peptidergic neurons. In Central Regulation of the Endocrine System. (eds Fuxe K, Hökfelt T, Luft. R); Plenum Press, New York, pp. 515-33.
58. Schofield PF, Jones DJ (1982). ABC of colorectal diseases. Br Med J 304: 1561-3.
59. Scott-Ringenberg Q, Doll DC (1989). Endocrine tumours and miscellaneous cancers in pregnancy. Semin Oncol 16: 445-9.
60. Silman AJ, Kay A, Brennan P (1992). Timing of pregnancy in relation to the onset of rheumatoid arthritis. Arthritis Rheum 35: 152-5.
61. Singaram C, Ashraf W, Gaumnitz EA et al. (1995). Dopamingergic defect of entire nervous system in Parkinson's disease patients with chronic constipation. Lancet 346: 861-4.
62. Thune I, Lund E (1996). Physical activity and risk of colorectal cancer in men and women. Br J Cancer 73: 1134-40.
63. Vanden Broucke JP, Boersma JW, Festen JJM, Valkenburg HA, Cats A, Huber-Bruning O, Rasker JJ (1982). Oral contraceptives and rheumatoid arthritis: further evidence of a preventive effect. Lancet 320: 839-43.
64. Van Kammen DF, Sternberg DE, Lake GR, Lerner P (1982). Methodological issues in spinal fluid studies of schizophrenia. Horm Res 9: 198-212.
65. Viru A (1985). Hormones in Muscular Activity. Vol II. Effect of Hormones in Exercise. CRC press. Boca Raton, p. 103.
66. Vittoratos N, Lairidas K, Zourlas PA (1996). Carcinoma of the colon during pregnancy. Int J Gynaecol Obstet 44: 72-3.
67. Walker ARP, Walker BF, Segal I (1993). Cancer patterns in three African populations compared with the United States black population. Eur J Cancer Prev 2: 313-20.
68. Walker ARP, Segal L (1989). Editorial: Puzzles in the epidemiology of colon cancer. J Clin Gastroenterol 11: 10-11.
69. Willett WC (1994) Diet and health: what should we eat? Science 264: 532-7.
70. Willett W, Sacks FM (1991). Chewing the fat: how much and what kind. Editorial comment. N Engl J Med 324: 73-7.
71. Williams CG, Goldman-Rakic PS (1995). Modulation of memory fields in prefrontal cortex. Nature 376: 572-5.
72. Wurtman RJ (1983). Behavioural effects of nutrients. Lancet 321: 1145-8.