In-vitro activity of spiramycin and metronidazole alone or in combination against clinical isolates from odontogenic abscesses

Journal of Antimicrobial Chemotherapy

Volumn 40, Issue 3, 1997, Pages 353-357

  Roche, Yvon ^a   Yoshimori, Robert N ^b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE; SPIRAMYCIN;

ABSCESS; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATION; BACTEROIDES; CLINICAL ARTICLE; EUBACTERIUM; FEMALE; HUMAN; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTOSTREPTOCOCCUS; PORPHYROMONAS; PREVOTELLA;

ANTI-BACTERIAL AGENTS; BACTERIA, AEROBIC; BACTERIA, ANAEROBIC; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; METRONIDAZOLE; MICROBIAL SENSITIVITY TESTS; PERIAPICAL ABSCESS; SPIRAMYCIN;

EID: 0030854326     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/40.3.353     Document Type: Article

References (21)

1. Labriola, J. D., Mascaro, J. & Alpert, B. (1983). The microbiologic flora of orofacial abscesses. Journal of Oral and Maxillofacial Surgery 41, 711-14.
2. Newman, M. G. (1984). Anaerobic oral and dental infection. Reviews of Infectious Diseases 6, Suppl. 1, S107-14.
3. Heimdahl, A., von Konow, L., Satoh, T. & Nord, C. E. (1985). Clinical appearance of orofacial infections of odontogenic origin in relation to microbiological findings. Journal of Clinical Microbiology 22, 299-302.
4. Sklavounos, A., Legakis, N. J., Ioannidou, H. & Patrikiou, A. (1986). Anaerobic bacteria in dentoalveolar abscesses. International Journal of Oral and Maxillofacial Surgery 15, 288-91.
5. Lewis, M. A. O., MacFarlane, T. W. & MacGowan, D. A. (1989). Antibiotic susceptibilities of bacteria isolated from acute dentoalveolar abscesses. Journal of Antimicrobial Chemotherapy 23, 69-77.
6. Iwu, C., MacFarlane, T. W., MacKenzie, D. & Stenhouse, D. (1990). The microbiology of periapical granulomas. Oral Surgery, Oral Medicine, Oral Pathology 69, 502-5.
7. Brook, I., Frazier, E. H. & Gher, M. E. (1991). Aerobic and anaerobic microbiology of periapical abscess. Oral Microbiology and Immunology 6, 123-5.
8. Murray, P. R. & Rosenblatt, J. E. (1977). Penicillin resistance and penicillinase production to clinical isolates of Bactteroides melaninogenicus. Antimicrobial Agents and Chemotherapy 11, 605-8.
9. Brook, I., Calhoun, L. & Yocum, P. (1980). Beta-lactamase-producing isolates of Bacteroides species from children. Antimicrobial Agents and Chemotherapy 18, 164-6.
10. Heimdahl, A., von Konow, L. & Nord, C. E. (1980). Isolation of beta-lactamase-producing Bacteroides strains associated with clinical failures with penicillin treatment of human orofacial infections. Archives of Oral Biology 25, 689-92.
11. Videau, D. (1971). Association métronidazole-spiramycine sur les germes anaérobies. Pathologie-Biologie 19, 661-6.
12. Laufer, J., Mignon, H. & Videau, D. (1974). L'association métronidazole-spiramycine. Concentrations et synergie in situ comparées aux CMI de la flore buccale. Revue de Stomatologie et de Chirurgie Maxillo-Faciale 74, 387-92.
13. Videau, D., Laufer, J. & Mignon, H. (1976). Métronidazole et spiramycine, une entité antimicrobienne originale en odontostomatologie. Revue de Stomatologie et de Chirurgie Maxillo-Faciale 77, 364-9.
14. Brook, I. (1987). Metronidazole and spiramycin in abscesses caused by Bacteroides spp. and Staphylococcus aureus in mice. Journal of Antimicrobial Chemotherapy 20, 713-18.
15. Brook, I. (1988). Synergy between spiramycin and metronidazole in the treatment of polymicrobial infections. Journal of Antimicrobial Chemotherapy 22, Suppl. B, 78-85.
16. Balows, A., Hauster, W. S., Hermann, K. L., Isermberg, H. D. & Shadomy, H. J. (1991). Manual of Clinical Microbiology, 5th edn. American Society for Microbiology, Washington, DC.
17. von Konow, L. & Nord, C. E. (1983). Ornidazole compared to phenoxymethylpenicillin in the treatment of orofacial infections. Journal of Antimicrobial Chemotherapy 11, 207-15.
18. Leung, F. C., Gardner, J. M., Paor, W. S. & Yankell, S. L. (1972). Spiramycin excretion in animals. II. Repeated oral doses in rats. Journal of Dental Research 51, 712-15.
19. Rotzetter, P. A., Le Liboux, A., Richard, E. & Cimasoni, G. (1994). Kinetics of spiramycin/metronidazole (Rodogyl®) in human gingival crevicular fluid, saliva and blood. Journal of Clinical Periodontology 21, 595-600.
20. Quee, T. C., Roussou, T. & Chan, E. C. S. (1983). In vitro activity of Rodogyl against putative periodontopathic bacteria. Antimicrobial Agents and Chemotherapy 24, 445-7.
21. Quee, T. C., Chan, E. C. S., Clark, C., Lautar-Lemay, C., Bergeron, M. J., Bourgouin, J. et al. (1987). The Role of adjunctive Rodogyl therapy in the treatment of advanced periodontal disease. Journal of Periodontology 58, 594-601.