A double-masked comparison of Naprelan® and nabumetone in osteoarthritis of the knee

Clinical Therapeutics

Volumn 19, Issue 4, 1997, Pages 642-655

  Fleischmann, Roy M ^a   Flint, Kathleen ^b   Constantine, Ginger ^c   Kolecki, Barbara ^c  

^a METROPLEX CLINICAL RESEARCH CENTER   (United States)

^b PA ^*  (United States)

^c WYETH AYERST RESEARCH   (United States)

Author keywords

Nabumetone; Naprelan ; Naproxen sodium; Oseoarthritits

Indexed keywords

ACETYLSALICYLIC ACID; HISTAMINE H2 RECEPTOR ANTAGONIST; NABUMETONE; NAPROXEN; PLACEBO;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; DYSPEPSIA; FEMALE; FLATULENCE; HEADACHE; HUMAN; LEUKOCYTOSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; NEUROPATHY; OSTEOARTHRITIS; PAIN; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SKIN DISEASE; STATISTICS; SUSTAINED RELEASE FORMULATION; URINARY TRACT INFECTION;

EID: 0030854287     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(97)80090-2     Document Type: Article

References (9)

1. Devane JG, Butler J, Mulligan S. IPDAS: A novel technology brings new benefits when applied to naproxen sodium. Am J Orthop. 1996;25(Suppl 9):7-13.
2. Gaston G. A double-blind, randomized, parallel-group study of the pharmacokinetics and onset of action of Naprelan in patients following oral surgery. Am J Orthop. 1996;25(Suppl 9):37-41.
3. Todd PA, Clissold SP. Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states. Drugs. 1990;40:91-137.
4. Pisko EJ, Bockow BI, Box P, et al. Six-month multi-center study comparing nabumetone with naproxen in the treatment of osteoarthritis. Am J Med. 1987;83 (Suppl 4B):86-91.
5. Poiley JE. Nabumetone versus naproxen in the treatment of osteoarthritis. A six-month trial. Am J Med. 1987;83(Suppl 4B):82-85.
6. Pisko EJ, Strader K, Rice D, et al. A 6-month, double-blind study comparing nabumetone to naproxen in the treatment of osteoarthritis. Pharmatherapeutica. 1987; 5:90-98.
7. Schiff MH. A comparison of Naprelan and Naprosyn in the treatment of osteoarthritis of the knee. Am J Orthop. 1996;25 (Suppl 9):14-20.
8. Data on file, Wyeth-Ayerst Laboratories, 1997.
9. Allen B, Edwards IR. A safety profile of controlled release naproxen tablets. New Zealand Med J. 1989;102:310-312.