Permeability of a neuroprotective compound NS-7 into brain: Comparison between normal and middle cerebral artery-occluded rats

Life Sciences

Volumn 61, Issue 10, 1997, Pages 957-966

  Itoh, Yoshinori ^a   Aoki, Yasuaki ^a   Nonaka, Kiyoko ^a   Ukai, Yojiro ^a   Yoshikuni, Yoshiaki ^a   Kimura, Kiyoshi ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

Middle cerebral artery occlusion; Neuroprotectant; NS 7

Indexed keywords

4 (4 FLUOROPHENYL) 2 METHYL 6 (5 PIPERIDINOPENTYLOXY)PYRIMIDINE; NEUROPROTECTIVE AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CALCIUM CHANNEL BLOCKERS; CEREBRAL ARTERIES; CEREBRAL CORTEX; CORPUS STRIATUM; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; NEUROPROTECTIVE AGENTS; PERMEABILITY; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS;

ANIMALIA;

EID: 0030852824     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)00600-0     Document Type: Article

References (26)

1. Y. AOKI, Y, R. SHIBAHARA, Y. ITOH, Y. UKAI, Y. YOSHIKUNI and K. KIMURA, Jpn. J. Pharmacol. 73 (suppl.) 90P (1997).
2. Y. TAKAGAKI, Y. ITOH, Y. AOKI, Y. UKAI, Y. YOSHIKUNI and K. KIMURA, J. Neurochem., in press.
3. T. SHIMIDZU, Y. ITOH, S. TATSUMI, S. HAYASHI, Y. UKAI, Y. YOSHIKUNI and K. KIMURA, Naunyn-Schmiedeberg's Arch. Pharmacol., in press.
4. C. SUMA, S. HAYASHI, T. SHIMIZU, Y. UKAI, Y. YOSHIKUNI and K. KIMURA, Jpn. J. Pharmacol. 73 (suppl.) 193P (1997).
5. S. ORRENIUS, D.J. MCCONKEY, G. BELLOMO and P. NICOTERA, Trends Pharmacol. Sci. 10 281-285 (1989).
6. D.W. CHOI, J. Neurosci. 10 2493-2501 (1990).
7. A.M. BUCHAN, S.Z. GERTLER, H. LI, D. XUE, Z.-G. HUANG, K.E. CHAUNDY, K. BARNES and H.J. LESIUK, J. Cereb. Blood Flow Metab. 14 903-910 (1994).
8. P.G. LYSKO, C.L. WEBB, T.-L. YUE, J.-L. GU and G. FEUERSTEIN, Stroke 25 2476-2482 (1994).
9. J.J. LYNCH III, S.P. YU, L.M.T. CANZONIERO, S.L. SENSI and D.W. CHOI, J. Pharmacol. Exp. Ther. 273 554-560 (1995).
10. J. GLOWINSKI and L.L. IVERSEN, J. Neurochem. 13 655-669 (1966).
11. G. PAXINOS and C. WATSON, Academic Press, Sydney, 1982.
12. Y. ITOH, T. SUGIMOTO, Y. UKAI, A. MORINO and K. KIMURA, J. Pharm. Pharmacol. 47 833-836 (1995).
13. T. TERASAKI, Y. DEGUCHI, Y. KASAMA, W.M. PARDRIDGE and A. TSUJI, Int. J. Pharmaceu. 81 143-152 (1992).
14. A. TAMURA, D. I. GRAHAM, J. MCCULLOCH and G. M. TEASDALE, J. Cereb. Blood Flow Metab. 1 53-60 (1981).
15. L. BITO, H. DAVSON, E. LEVIN, M. MURRAY and N. SNIDER, J. Neurochem. 13 1057-1067 (1966).
16. U. UNGERSTEDT and A. HALLSTRÖM, Life Sci. 41 861-864 (1987).
17. U. UNGERSTEDT, M. HERRERA-MARSCHITZ, U. JUNGNELIUS, L. STÅHLE, U. TOSSMAN and T. ZETTERSTRÖM, Advances in Dopamine Research, M. Kohsaka, T. Shohmori, Y. Tsukada and G.N. Woodruff (Eds), 219-231, Pergamon Press, New York (1982).
18. H. BENVENISTE J. Neurochem. 52 1667-1679 (1989).
19. S. TATSUMI, Y. ITOH, F.-H. MA, Y. UKAI, Y. YOSHIKUNI and K. KIMURA, Jpn. J. Pharmacol. 73 (suppl.) 193P (1997).
20. W.A. CATTERALL, Science 242 50-61 (1988).
21. W.A. CATTERALL, Physiol. Rev. 72 S15-S48 (1992).
22. M.J. LEACH, J.H. SWAN, D. EISENTHAL, M. DOPSON and M. NOBBS, Stroke 24 1063-1067 (1993).
23. S.H. GRAHAM, J. CHEN, J. LAN, M.J. LEACH and R.P. SIMON, J. Pharmacol. Exp. Ther. 269 854-859 (1994).
24. F.C. BARONE, P.G. LYSKO, W.J. PRICE, G FEUERSTEIN, K.A. AL-BARACANJI, C.D. BENHAM, D.C. HARRISON, M.H. HARRIES, S.J. BAILEY and A.J. HUNTER, Stroke 26 1683-1690 (1995).
25. S.E. SMITH and B.S. MELDRUM, Stroke 26 117-122 (1995).
26. A. TAMURA, D. I. GRAHAM, J. MCCULLOCH and G. M. TEASDALE, J. Cereb. Blood Flow Metab. 1 61-69 (1981).