UGP - A tumor marker of gynecologic and breast malignancies? Specificity and sensitivity in pretherapeutic patients and the influence of hormonal substitution on the expression of UGP

Anticancer Research

Volumn 17, Issue 4 B, 1997, Pages 3041-3045

  Schwarz Roeger, Ulrike ^a   Petzoldt, Bettina ^a   Waldschmidt, Rainer ^b   Walker, Roger P ^c   Bauknecht, Thomas ^a   Kiechle, Marion ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Ciba Corning Diagnostics GmbH   (Germany)

^c Ciba Corning Diagnostics Corp   (United States)

Author keywords

Gynecologic and breast cancer; Hormonal substitution; UGP

Indexed keywords

CREATININE; GONADOTROPIN; PEPTIDE; TUMOR MARKER;

BREAST CANCER; BREAST CARCINOMA; BREAST DISEASE; BREAST TUMOR; CARCINOMA IN SITU; CONFERENCE PAPER; CONTROLLED STUDY; CREATININE URINE LEVEL; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; ENDOMETRIUM CANCER; FEMALE; FEMALE GENITAL TRACT TUMOR; GYNECOLOGIC DISEASE; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; TUMOR DIAGNOSIS; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; VAGINA CANCER; VULVA CANCER;

EID: 0030852396     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (43)

1. Swaminathan N and Bahl OP: Dissociation and recombination of the subunits of human chorionic gonadotrophin. Biochem Biophys Res Commun 40: 422, 1970.
2. Morgan F and Canfield RC: Nature of the subunits of human chorionic gonadotrophin. Endocrinol 88: 1045, 1971
3. Pierce JG, Bahl OP, Cornell JS and Swaminathan N: Biologically active hormones prepared by recombination of the alpha chain of human chorionic gonadotrophin and the hormone specific chain of bovine thyreotrophin or of bovine luteinizing hormone. J Biol Chem 29 (4): 667, 1970.
4. Hussa RO: Biosynthesis of human chorionic gonadotropin. Endocr Rev 1: 268-294, 1980.
5. Blithe DL, Akar AH, Wehmann RE and Nisula BC: Purification of beta core fragment from pregnancy urine and demonstration that its carbohydrate moieties differ from those of native chorionic gonadotropin. Endocrinol 122: 173-180, 1988.
6. Blithe DC, Wehmann RE and Nisula BC: Carbohydrate composition of beta-core. Endocrinol 125: 2267-2272, 1989.
7. Endo TR, Nishimura R, Saito S and Kanazawa K: Carbohydrate structures of beta-core fragment of human chorionic gonadotropin isolated from a pregnant individual. Endocrinol 130: 2052-2058, 1992.
8. Good A, Ramos-Uribe M, Ryan RJ and Kempers RD: Molecular forms of human chorionic gonadotropin in serum, urine and placental extracts. Fertil Steril 28: 846-850, 197
9. Birken S, Amstrong EG, Gawinowicz Kolks MA, Cole LA, Agosto GM, Krichevsky A, Vaitukaitis JL and Canfield RE: Structure of the human chorionic gonadotropin ß-core fragment from pregnancy urine. Endocrinol 123: 572-583, 1988.
10. Franchimont P, Gaspar U, Reuter A and Heynen G: Polymorphism of protein and polypeptide hormones. Clin Endocrinol 1: 315-336, 1972.
11. Good A, Ramos-Uribe M, Ryan RJ and Kempers RD: Molecular forms of human chorionic gonadotropin in serum, urine and placental extracts. Fertil Steril 28: 846-850, 1977.
12. Kato Y and Braunstein GD: ß-core fragment is a major form of immunoreactive urinary chorionic gonadotropin in human pregnancy. J Clin Endocrinol and Metab 66: 1997-1201, 1988.
13. Puett D, Kenner A, Benveniste R and Rabinowitz D: Characterization of the human chorionic gonadotrophin fractions in pregnancy urine. Acta Endocrinol 89: 612-624, 1978.
14. Schroeder HR and Halter CM: Specificity of human beta-choriogonadotropin assays for the hormone and for an immunoreactive fragment present in urine during normal pregnancy. Clin Chem 29: 667-671, 1983.
15. Masure HR, Jaffee WL, Sickel MA, Birken S, Canfield RE and Vaitukaitis JL: Characterization of a small molecular size urinary immunoreactive human chorionic gonadotropin (hCG)-like substance produced by normal placenta and by hCG-secreting neoplasms. J Clin Endocrinol and Metab 53/5: 1014-1020, 1981.
16. Papapetrou PD and Nicopoulou SC: The origin of human chorionic gonadotropin ß-subunit-core fragment excreted in the urine of patients with cancer. Acta Endocinol 112: 415-422, 1986.
17. Papapetrou PD, Sakarelou NP, Braouzi H and Fessas PH: Ectopic production of human chorionic gonadotropin (hCG) by neoplasms: The value of measurements of immunoreactive hCG in the urine as a screening procedure. Cancer 45: 2583-2592, 1980.
18. Hattori M, Yoshimoto Y, Matsukura S and Fujita T: Qualitative and quantitative analyses of human chorionic gonadotropin and its subunits produced by malignant tumors. Cancer 46: 355-361, 1980.
19. Hussa RO, Fein HG, Pattillo RA, Nagelberg SB, Rosen SW, Weintraub BD, Perini F, Ruddon RW and Cole LA: A distinctive form of human chorionic gonadotropin ß-Subunit-like material produced by cervical carcinoma cells. Cancer Res 45: 1948-1954, 1986.
20. Amr S, Rosa C, Wehmann RE, Birken S and Nisula BC: Unusual molecular forms of hCG in gestational trophoblastic neoplasia. Ann Endocrinol (Paris) 45: 321-326, 1984.
21. Nishimura R, Kitajiama T, Hasegava K and Takeuchi K: Molecular forms of human chorionic gonadotropin in chorioncarcinoma serum and urine. Jpn J Cancer Res 80: 968-974, 1989.
22. Cole LA, Wang Y, Elliott M, Latif M, Chambers JT, Chambers SK and Schwartz PE: Urinary human chorionic gonadotropin free ß-subunit and ß-core fragment: A new marker of gynecological cancers. Caner Res 48: 1356-1360, 1988.
23. Nam IH, Cole LA, Chambers JT and Schwartz PE: Urinary gonadotropin fragment, a new tumor marker: I. Assay development and cancer specificity. Gynecol Oncol 36: 383-390, 1990.
24. Cole LA, Hartle RI, Laferla JJ and Ruddon RW: Detection of the Free Beta Subunit of Human Chorionic Gonadotropin (hCG) in Cultures of Normal and Malignant Trophoblast Cells, Pregnancy Sera, and Sera of Patients With Choriocarcinoma. Endocrinol 113: 1176-1178, 1983.
25. Cole LA and Birken S: Origin and occurrence of human chorionic gonadotropin ß-subunit core fragment. Mol Endocrinol 2: 825-830, 1988.
26. Franchimont P, Reuter A and Gaspard U: Ectopic production of human chorionic gonadotrophin and its alpha and beta subunits. Curr Top Exp Endocrinol 3: 301-216, 1978.
27. Wehmann RE, Blithe DL, Akar AH and Nisula BC: Disparity between ß-core levels in pregnancy urine and serum: implications for the origin of urinary ß-core. J Clin Endocrinol and Metab 70: 371-378, 1990.
28. Nisula C, Blithe DL, Akar A, Lefort G and Wehmann RE: Metabolic fate of human choriogonadotropin. J Steroid Biochem Mol Biol 33: 733-737, 1989.
29. Wehmann RE, Blithe DL, Flack MR and Akar AH: Metabolic clearance rate and urinary clearance of beta-core in humans In: International symposium on glycoprotein hormones, Newport Beach, 1988, abstract 1-12.
30. Kardana A and Cole LA: Serum hCG beta-core fragment is masked by associated macromolecules. J Clin Endocrinol and Metab 71/5: 1393-1395, 1990.
31. Braunstein GD: Beta-core fragment: structure, production, metabolism and clinical utility. In: The symposium on glycoprotein hormones: structure function and clinical implications, Santa Barbara, 1993, pp 21.
32. Walker R, Crebbin V, Stern J, Scudder S and Schwartz P: Urinary gonadotropin peptide (UGP) as a marker of gynecologic malignancies. Anticancer Res 14: 1703-1710, 1994.
33. Jaffe M: Über den Niederschlag, welchen Pikrinsäure im normalen Harn erzeugt, und über eine neue Reaktion des Kreatinins. Hoppe-Seylers Z Physiol Chem 10: 391-400, 1886.
34. Blass KG, Thibert RJ and Lam LK: A study of the mechanism of the Jaffé-reaction. Z Physiol Chem 12: 336-343, 1974.
35. Larsen K: Creatinine assay by a reaction -kinetic principle. Clin Chim Acta 42: 209, 1972.
36. Neven P, Iles RK, Lee CL, Hudson CN, Shepherd JH and Chard T: Urinary chorionic gonadotropin subunits and ß-core in nonpregnant women. Cancer 71: 4124-4130, 1993.
37. Cole A and Nam JH: Urinary gonadotropin Fragment (UGF) measurements in the diagnosis and management of ovarian cancer. Y J Biol and Med 62: 367-378, 1989.
38. Lee CL, Iles RK, Shepherd JH, Hudson CN and Chard T: The purification and development of a radioimmunoassay for ß-core fragment of human chorionic gonadotrophin in urine: application as a marker of gynecological cancer in premenopausal and postmenopausal women. J Endocrinol 130: 481-489, 1991.
39. Stenan U-H, Alfthan H, Ranta T, Vartianinen E, Jalkanen J and Seppala M: Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin-realising hormone and sex steroid. J Clin Endocrinol and Metab 64: 730-736, 1988.
40. Odell WD and Griffin J: Pulsatile secretion of human chorionic gonadotropin in normal adult. N Engl J Med 317: 1688-1695, 1987.
41. Akar AH, Gervasi G, Blacker C and Wehmann RE: Human chorionic gonadotropin-like and ß-core-like materials in postmenopausal urine. J Endocrinol 125: 477-484, 1990.
42. Neven P, Iles R, Howes I and Sharma K: Substantial urinary concentrations of material resembling ß-core fragment of chorionic gonadotropin ß-subunit in mid-menstrual cycle. Clin Chem 39/9: 1857-1860, 1993.
43. Birken S, Chen Y, Gawinowicz MA, Agosto GM, Canfield RE and Hartree AS: Structure and significance of human luteinizing hormone-beta-core fragment purified from human pituitary exstracts. Endocrinol 133/3: 985-989, 1993.