Platelet function in cirrhosis and the role of humoral factors

European Journal of Gastroenterology and Hepatology

Volumn 9, Issue 10, 1997, Pages 989-992

  Younger, Hazel M ^a   Hadoke, Patrick W F ^a   Dillon, John F ^a   Hayes, Peter C ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Aggregation; Cirrhosis; Plasma factors; Platelets

Indexed keywords

BIOLOGICAL FACTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LIVER CIRRHOSIS; MALE; PLASMA; PRIORITY JOURNAL; TEACHING HOSPITAL; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE ANOMALY; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA;

EID: 0030852387     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199710000-00012     Document Type: Article

References (19)

1. Thomas DP, Ream VP, Stuart RK: Platelet aggregation in patients with Laennec's cirrhosis of the liver. N Engl J Med 1967, 276:1344-1348.
2. Mammen EF: Coagulation defects in liver disease. Med Clin North Am 1994, 78:545-554.
3. Thomas DP: Abnormalities of platelet aggregation in patients with alcoholic cirrhosis. Ann NY Acad Sci 1972, 201:243-250.
4. Grose RD, Hayes PC: The pathophysiology and pharmacological treatment of portal hypertension. Aliment Pharmacol Ther 1992, 6:521-540.
5. Holmsen H: Significance of testing platelet functions in vitro. Eur J Clin Invest 1994, 24(suppl. 1):3-8.
6. Brass LF, Hoxie JA, Manning DR: Signaling through G-proteins and C-protein-coupled receptor during platelet activation. Thromb Haemost 1993, 70:217-223.
7. Rubin MH, Weston MJ, Langley PC, et al.: Platelet function in chronic liver disease - relationship to disease severity. Dig Dis Sci 1979, 24:197-202.
8. Owen JS, Hutton RA, Day RC, et al.: Platelet lipid composition and platelet aggregation in human liver disease. J Lipid Res 1981, 22:423-430.
9. Laffi G, Cominelli F, Ruggiero M, et al.: Molecular mechanism underlying impaired platelet responsiveness in liver cirrhosis. FEBS Lett 1987, 220:217-219.
10. Laffi G, Cominelli F, Ruggiero M, et al.: Altered platelet function in cirrhosis of the liver: Impairment of inositol, lipid and arachidonic acid metabolism in response to agonists. Hepatology 1988, 8:1620-1626.
11. Desai K, Mistry P, Bagget C, et al.: Inhibition of platelet aggregation by abnormal high density lipoprotein particles in plasma from patients with hepatic cirrhosis. Lancet 1989, i:693-694.
12. Laffi G, Marra F, Failli P, et al.: Defective signal transduction in platelets from cirrhotics is associated with increased cyclic nucleotides. Gastroenterology 1993, 105:148-156.
13. Forrest EH, Henderson NC, Newsome PN, et al.: Impaired platelet aggregation in cirrhosis may be due to a circulating factor [abstract]. Scott Med J 1994, 40(3):95.
14. Forrest EH, Dillon JF, Campbell TJ, et al.: Platelet basal cytosolic calcium: the influence of plasma factors in cirrhosis. J Hepatol 1996, 25:312-315.
15. De Mikulic LEP, Auclair M-C, Vernimmen C, et al.: Plasma from cirrhotic patients induces inotropic changes on cultured rat heart cells. Life Sci 1987, 41:2177-2184.
16. Pugh RNH, Murray-Lyon IM, Dawson JL, et al.: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973, 60:646-649.
17. Roper BP, Drewinko B, Hasler D, et al.: Effects of time, platelet concentration and sex on the human platelet aggregation response. Am J Clin Pathol 1979, 71:263-268.
18. Zucker M: Platelet aggregation measured photometrically. Methods Enzymol 1989, 169:117-133.
19. Bloom D, McCalden TA, Rosendorff C: Effects of jaundiced plasma on vascular sensitivity to noradrenalin. Kidney Int 1975, 8:149-157.