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(a) Audia, J. E.; Boisvert, L.; Patten, A. D.; Villalobos, A.; Danishefsky, S. J. J. Org. Chem. 1989, 54, 3738.
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(b) Jeroncic, L. O.; Cabal, M.-P.; Danishefsky, S. J. J. Org. Chem. 1991, 56, 387. The cyclohexylidene analogue of compound 4 had been observed previously in work related to ref 6.
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8544284977
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note
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The ease with which this elimination occurs is probably due to the boat conformation of the cyclohexane ring which is imposed by the isopropylidene acetal ring. In unconstrained systems this elimination occurs less readily. See ref 13.
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8544284245
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Cerium could also function in a similar way to zinc but without the consequent ring opening
-
Cerium could also function in a similar way to zinc but without the consequent ring opening.
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34
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