Ischemic optic neuropathy: Models for mechanism of disease

Clinical Neuroscience

Volumn 4, Issue 5, 1997, Pages 264-269

  Potarazu, Sreedhar V ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Northern Virginia Ophthalmology Associates   (United States)

Author keywords

AION; Axonal injury; Calcium channels

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; NIMODIPINE;

AUTOREGULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; EYE BLOOD FLOW; HUMAN; INTRAOCULAR PRESSURE; ION CURRENT; ISCHEMIC OPTIC NEUROPATHY; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; OPTIC DISK; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; VASCULAR ENDOTHELIUM;

BLOOD PRESSURE; CALCIUM CHANNELS; HUMANS; INTRAOCULAR PRESSURE; ISCHEMIA; MODELS, BIOLOGICAL; OPTIC DISK; OPTIC NEUROPATHY, ISCHEMIC; RISK FACTORS;

EID: 0030851846     PISSN: 10656766     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

1. Astrup J, Siesjo BK, Symon L (1981): Thresholds in cerebral ischemia - the ischemic penumbra. Stroke 12:733-725.
2. Boghen DR, Glaser JS (1975): Ischaemic optic neuropathy: The clinical profile and natural history. Brain 98:689-708.
3. Burde RM (1994): Optic disk risk factors for nonarteritic ischemic optic neuropathy. Am J Opthalmol 117:822.
4. Chan PH (1996): Role of oxidants in ischemic "brain" damage. Stroke 6:1124-1129.
5. Choi DW (1988b): Calcium mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci 11:465-469.
6. Glaser JS (1990): Neuro-Ophthalmology, 2nd ed. Philadelphia: JB Lippincott.
7. Guyer DR, Miller NR, Auer CL, Fine SL (1985): The risk of cerebrovascular and cardiovascular disease in patients with anterior ischemic optic neuropathy. Arch Ophthalmol 103:1136.
8. Hansen AJ (1985): Effect of anoxia on ion distribution in the brain. Physiol Rev 65:101-148.
9. Hayreh SS, Zimmerman MB, Podjajsky P, Alward WL (1994): Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthal 15:603-624.
10. Heiss WD, Hayakawa T, Waltz AG (1976): Cortical neuronal function during ischemia. Effects of occlusion of one middle cerebral artery on single-unit activity in cats. Arch Neurol 33:813-820.
11. Kelman SE (1995): Optic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful: The ischemic optic neuropathy decompression trial research group. JAMA 273:666-667.
12. Levine GN, Keaney JF Jr, Vita JA (1995): Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med 332:481-187.
13. McLeod D, Marshall J, Kohner EM (1980): Role of axoplasmic transport in the pathophysiology of ischaemic disc swelling. Br J Ophthalmol 64:247.
14. Miller NR (1982): Anterior ischemic optic neuropathy. In Miller NR (ed): Walsh and Hoyt's Clinical Neuro-Ophthalmology. 4th ed. Baltimore, MD: Williams & Wilkins, pp 212-226.
15. Quigley HA, Flower RW, Addicks EM, McLeod DS (1980): The mechanism of optic nerve damage in experimental acute intraocular pressure elevation. Invest Opthalmol Vis Sci 19:505-517.
16. Ransom BR, Walz W, Davis PK, Carlini WG (1992): Anoxia-induced changes in extracellular K+ and pH in mammalian central white matter. J Cereb Blood Flow Metab. 103:23-28.
17. Schanne FA, Kane AB, Young EE, Farber JL (1979): Calcium-dependence of toxic cell death: A final common pathway. Science 206:700-702.
18. Siesjö BK (1986): Calcium and ischemic brain damage. Eur Neurol 25:45-56.
19. Stys PK, Ransom BR, Waxman SG, Davis PK (1990): The role of extracellular calcium in anoxic injury in mammalian white matter. Proc Natl Acad Sci USA 87:4212-4216.
20. Stys PK, Ransom BR, Waxman SG (1991): Compound action potential of nerve recorded by suction electrode: A theoretical and experimental analysis. Brain Res 546:18-32.
21. Stys PK, Waxman SG, Ransom BR (1992): Ionic mechanisms of anoxic injury in mammalian CNS white matter: Role of Na+ channels and Na+-Ca2+ exchanger. J Neurosci 1:430-439.
22. Waxman SG, Ritchie JM (1985): Organization of ion channels in the myelinated nerves. Science 228:1502-1507.