A comparison of the effects of aspirin on bleeding time measured using the Simplate(TM) method and closure time measured using the PFA-100(TM), in healthy volunteers

British Journal of Clinical Pharmacology

Volumn 44, Issue 2, 1997, Pages 151-155

  Marshall, P W ^a   Williams, A J ^a   Dixon, R M ^a   Growcott, J W ^a   Warburton, S ^a   Armstrong, J ^a   Moores, J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Aspirin; Bleeding time; PFA 100; Simplate; Volunteers

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; PLACEBO;

ADULT; ARTICLE; BLEEDING TIME; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; MACHINE; MALE; MEASUREMENT; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TECHNIQUE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; VOLUNTEER;

EID: 0030851305     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1997.00639.x     Document Type: Article

References (13)

1. Duke WW. The relation of blood platelets to hemorrhagic disease: Description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA 1910; 55: 1185-1192.
2. Ivy AG, Nelson D, Butcher G. The standardization of certain factors in the cutaneous hemostasis bleeding time technique. J Lab Clin Med 1941; 26: 1812-1822.
3. Babson SR, Babson AL. Development and evaluation of a disposable device for performing simultaneous duplicate bleeding time determinations. Am J Clin Pathol 1978; 70: 406-408.
4. Orland E, Cartelazzo S, Marchetti M, Sanfratello R, Barbui T. Prolonged bleeding time in patients with lupus anticoagulant. Thromb Haemostas 1992; 68: 495-499.
5. Israels SJ, McNicol A, Robertson C, Gerrard JM. Platelet storage pool deficiency: Diagnosis in patients with prolonged bleeding times and normal platelet aggregation. Br J Haematol 1990; 75: 118-121.
6. Simoons ML, de Boer MJ, van den Brand MJBM, et al. Randomized trial of a GpIIb/IIIa platelet receptor blocker in refractory unstable angina. Circulation 1994; 89: 596-603.
7. Kereiakes DJ, Kleiman NS, Ambrose J, et al. Randomized, double-blind, placebo-controlled, dose-ranging study of Tirofiban (MK-383) platelet IIb/IIIa blockade in high-risk patients undergoing coronary angioplasty. J Am Coll Cardiol 1996; 27: 536-542.
8. Kundu SK, Heilmann EJ, Sio R, Garcia C, Davidson RM, Ostgaard RA. Description of and in vitro platelet function analyzer - PFA-100™. Seminars Thromb Haemostas 1995; 21(S2): 106-112.
9. Mammen EF, Alshameeri RS, Comp PC. Preliminary data from a field trial of the PFA-100™ system. Seminars Thromb Haemostas 1995; 21(S2): 113-121.
10. Mielke CH. Influence of aspirin on platelets and the bleeding time. Am J Med 1983; 74: 72-78.
11. Kratzer MAA, Born GVR. Simulation of primary hemostasis in vitro. Haemostasis 1985; 15: 357-362.
12. Alshameeri RS, Mammen EF. Performance characteristics and clinical evaluation of an in vitro bleeding time device - Thrombostat 4000. Thrombosis Res 1995; 79: 275-287.
13. Kretschmer V, Schikor B, Söhngen D, Dietrich G. In vitro bleeding test - a simple method for the detection of aspirin effects on platelet function. Thrombosis Res 1989; 56: 593-602.