Amrinone versus dobutamine in cardiac surgical patients with severe pulmonary hypertension after cardiopulmonary bypass: A prospective, randomized double-blinded trial

Anaesthesia and Intensive Care

Volumn 25, Issue 3, 1997, Pages 245-249

  Jenkins, I R ^a,b   Dolman, J ^a,c   O'Connor, J P ^a,c   Ansley, D M ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b FREMANTLE HOSPITAL   (Australia)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

Surgery, anaesthesia: cardiac, mitral valve, cardiopulmonary bypass, pulmonary hypertension, dobutamine, amrinone

Indexed keywords

AMRINONE; CARDIOTONIC AGENT; DOBUTAMINE;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CENTRAL VENOUS PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; FEMALE; HEART INDEX; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART RIGHT VENTRICLE EJECTION FRACTION; HEART RIGHT VENTRICLE FUNCTION; HEART STROKE VOLUME; HEART SURGERY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG ARTERY PRESSURE; LUNG PRESSURE; LUNG WEDGE PRESSURE; MALE; MEAN ARTERIAL PRESSURE; MITRAL VALVE REPLACEMENT; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; WEANING;

EID: 0030851303     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x9702500306     Document Type: Article

References (12)

1. Jackson JM, Thomas SJ. Valvular heart disease. In: Kaplan JA, ed. Cardiac Anesthesia. W. B. Saunders, Philadelphia 1993; 629-680.
2. Dupuis J-Y, Bondy R, Cattran C, Nathan HJ, Wyands JE. Amrinone and dobutamine as primary treatment of low cardiac output syndrome following coronary artery surgery: a comparison of their effects on haemodynamics and outcome. J Cardiothorac Vasc Anesth 1992;6:542-553.
3. Royster RL, Butterworth JF 4th, Prielipp RC, et al. Combined inotropic effects of amrinone and adrenaline after cardiopulmonary bypass in humans. Anesth Analg 1993;77:662-672.
4. Deeb GM, Bolling SF, Guynn TP, Nicklas JM. Amrinone versus conventional therapy in pulmonary hypertensive patients awaiting cardiac transplantation. Ann Thorac Surg 1989; 48:665-669.
5. Petry A, Dutschke P. Effects of amrinone on left and right ventricular function in patients with impaired myocardial performance during general anaesthesia. Br J Anaesth 1994; 72:567-570.
6. Cheng DCH, Asokumar B, Nakagawa T. Amrinone therapy for severe pulmonary hypertension and biventricular failure after complicated valvular heart surgery. Chest 1993; 104:1618-1620.
7. Butterworth JF 4th, Royster RL, Prielipp RC, Lawless ST, Wallenhaupt SL. Amrinone in cardiac surgical patients with left-ventricular dysfunction: A prospective, randomized placebo-controlled trial. Chest 1993; 104:1660-1667.
8. Keogh B, Priddy R, Morgan C, Gillbe C. Comparative study of the effects of enoximone and dobutamine in patients with impaired left ventricular function undergoing cardiac surgery. Cardiology 1990; 77(Suppl 3):58-61.
9. Bailey JM, Levy JH, Rogers HG, Szlam F, Hug CC Jr. Pharmacokinetics of amrinone during cardiac surgery. Anesthesiology 1991; 75:961-968.
10. Feneck RO. Effects of variable dose milrinone in patients with low cardiac output after cardiac surgery. Am Heart J 1991; 121:1995-1999.
11. Wright EM, Skoyles J, Sherry KM. Milrinone in the treatment of low output states following cardiac surgery. Eur J Anaesth 1992; Suppl 5:21-26.
12. Jenkins IR. The FIII selective phosphodiesterase inhibitors in intensive care: The emperor's new clothes or the best thing since Swan Ganz catheters? In: Keneally J, Jones M, eds. Australasian Anaesthesia 1996, Australian and New Zealand College of Anaesthetists, Melbourne 1996; 227-235.