Evolving concepts in the pathophysiology of thrombosis in acute ischaemic syndromes

International Journal of Clinical Practice, Supplement

Volumn , Issue 90, 1997, Pages 7-12

  Darius, H ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; NITRIC OXIDE; PROSTACYCLIN; SELECTIN; THROMBOPLASTIN; THROMBOXANE A2; VASCULAR CELL ADHESION MOLECULE 1;

ATHEROSCLEROTIC PLAQUE; CONFERENCE PAPER; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM INJURY; MACROPHAGE; MONOCYTE; NEUTROPHIL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOSIS; VASCULAR SMOOTH MUSCLE;

EID: 0030851008     PISSN: 1368504X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (33)

1. Fuster V, Lewis O. Conner Memorial Lecture: Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 1994; 90: 2126-2146.
2. Badimon L, Chesebro JR, Badimon JJ. Thrombus formation on ruptured atherosclerotic plaques and rethrombosis on evolving thrombi. Circulation 1992; 86: III-74-III-85.
3. Van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994; 89: 36-44.
4. Zeiher AM, Schächinger V, Hohnloser SH et al. Coronary atherosclerotic wall thickening and vascular reactivity in humans: elevated high density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 1994; 89: 2525-2532.
5. Zeiher AM, Schächinger V, Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. Circulation 1995: 92: 1094-1100.
6. Frink RJ. Chronic ulcerated plaques: new insights into the pathogenesis of acute coronary disease. J Invas Cardiol 1994; 6: 173-185.
7. Farb A, Burke AP, Tang AL et al. Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death. Circulation 1996; 93: 1354-1363.
8. Moreno PR, Falk E, Palacios IF et al. Macrophage infiltration in acute coronary syndromes: implications for plaque rupture. Circulation 1994; 90: 775-778.
9. Falk E. Why do plaques rupture? Circulation 1992; 86: III-30-III-40
10. Brady AJB. Neutrophils in heart disease - stormtroopers of the immune system. Eur Heart J 1995; 16: 151-152.
11. Mazzone A, DeServi S, Ricevuti G et al. Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease. Circulation 1993; 88: 358-363.
12. DeServi S, Mazzone A, Ricevuti G et al. Clinical and angiographic correlates of leukocyte activation in unstable angina. J Am Coll Cardiol 1995; 26: 1146-1150.
13. Frenette PS, Wagner DD. Adhesion molecules (Part 1). N Engl J Med 1996; 334: 1526-1529.
14. Frenette PS, Wagner DD. Adhesion molecules (Part 2). N Engl J Med 1996; 335: 43-45.
15. Jang Y, Lincoff M, Plow EF, Topol EJ. Cell adhesion molecules in coronary artery disease. J Am Coll Cardiol 1994; 24: 1591-1601.
16. Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest 1991; 88: 1121-1127.
17. Liuzzo G, Biasucci LM, Gallimore JR et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med 1994; 331: 417-424.
18. Brown DL, Hibbs MS, Kearny M et al. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: association of active enzyme synthesis with unstable angina. Circulation 1995; 91: 2125-2131.
19. Shah PK, Falk E, Badimon JJ et al. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques: potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation 1995; 92: 1565-1569.
20. Rupprecht HJ, Sohn HY, Kearney P et al. Clinical predictors of unstable coronary lesion morphology. Eur Heart J 1995; 16: 1526-1534.
21. Stary HC, Chandler AB, Dinsmore RE et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995; 92: 1355-1374.
22. Fernandez-Ortiz A, Badimon JJ, Falk E et al. Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture. J Am Coll Cardiol 1994; 23: 1562-1569.
23. Spiecker M, Darius H, Meyer J. Synergistic platelet antiaggregatory effects of the adenylate cyclase activator iloprost and the guanylate cyclase activating agent SIN-I in vivo. Thromb Res 1993; 70: 405-415.
24. Fisch A, Michael-Hepp J, Meyer J, Darius H. Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-I on platelet cyclic AMP. Eur J Pharmacol (Molecular Pharmacol Section) 1995; 289: 455-461.
25. De Caterina R, Libby P, Peng HB et al. Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995; 96: 60-68.
26. Spiecker M, Darius H, Hubner F et al. Nitric oxide donors inhibit cytokine induced adhesion molecule expression on human endothelial cells. Circulation 1995; 92 (Suppl): 2419.
27. Niu XF, Smith CW, Kubes P. Intracellular oxidative stress induced by nitric oxide synthesis inhibition induces endothelial cell adhesion to neutrophils. Circ Res 1994; 74: 1133-1140.
28. Darius H, Grodzinska L, Meyer J. The effects of the nitric oxide-donors molsidomine and SIN-I on polymorphonuclear leukocyte function in vitro and ex vivo. Eur J Clin Pharmacol 1992; 43: 629-633.
29. Darius H, Brehm K, Klecker P et al. Activation of primed neutrophils by thrombin-stimulated autologous platelets is mediated by ADP. Naunyn Schmiederberg's Arch Pharmacol 1996; 353 (Suppl.): R81.
30. Fisch A, Klecker P, Brehm K, Darius H. Thrombin-stimulated platelets induce neutrophil oxygen burst and L-selectin shedding but no degranulation of neutrophil granules. Naunyn Schmiederberg's Arch Pharmacol 1996; 353 (Suppl.): R80.
31. Kahn NN, Mueller HS, Sinha AK. Impaired prostaglandin E1/prostacyclin receptor activity of platelets in acute ischemic heart disease. Circ Res 1990; 66: 932-940.
32. Darius H, Binz C, Veit K et al. Platelet receptor desensitization induced by elevated prostacyclin causes platelet - endothelial cell adhesion. J Am Coll Cardiol 1995; 26: 800-806.
33. Fisch A, Tobusch K, Darius H et al. Prostacyclin receptor desensitization is a reversible phenomenon in human platelets. Circulation 1997 (In press).