Pharmacological reversal of advanced glycation-end-product-mediated protein crosslinking

Diabetologia

Volumn 40, Issue SUPPL. 2, 1997, Pages

  Ulrich, P ^a   Zhang, X ^a  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; PHENACYLTHIAZOLIUM BROMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ATHEROGENESIS; ATHEROSCLEROSIS; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN GLYCOSYLATION; RAT;

ANIMALS; DIABETES MELLITUS; ERYTHROCYTES; GLYCOSYLATION END PRODUCTS, ADVANCED; IMMUNOGLOBULIN G; RATS; THIAZOLES;

EID: 0030850881     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051437     Document Type: Conference Paper

References (11)

1. Ledl F, Schleicher E (1990) New aspects of the Maillard reaction in foods and in the human body. Angew Chem Int Ed Engl 29: 565-594
2. Horiuchi S (1996) Advanced glycation end products (AGE)-modified proteins and their potential relevance to atherosclerosis. Trends Cardiov Med 6: 163-168
3. Palinski W, Koschinsky T, Butler SW, Miller E, Vlassara H, Cerami A, Witztum JL (1995) Immunological evidence for the presence of advanced glycosylation end products in atherosclerotic lesions of euglycemic rabbits. Arteriosc Thromb Vasc Biol 15: 571-582
4. Brownlee M, Vlassara H, Kooney A, Ulrich P, Cerami A (1986) Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232: 1629-1632
5. Dyer DG, Blackledge JA, Katz BM et al. (1991) The Maillard reaction in vivo. Zeitschr Ernahrungswiss 30: 29-45
6. Vasan S, Zhang X, Zhang X et al. (1996) An agent cleaving glucose-derived protein crosslinks in vitro and in vivo. Nature 382: 275-278
7. Huber B, Ledl F (1990) Formation of 1-amino-1,4-dideoxy-2,3-hexodiuloses and 2-aminoacetylfurans in the Maillard reaction. Carbohyd Res 204: 215-22 0
8. Chen HJC, Cerami A (1993) Mechanism of inhibition of advanced glycosylation by aminoguanidine in vitro. J Carbohyd Chem 12: 731-7 42
9. Estendorfer S, Ledl F, Severin T (1990) Formation of an aminoreductone from glucose. Angew Chem Int Ed Engl 29: 536-537
10. Vovk AI, Murav'eva IV, Yasnikov AA (1985) Mechanism of the cleavage of acetylbenzoyl in methanol catalyzed by thiazolium salts. Ukr Khim Zh, Russ Ed 51: 521-525
11. Zhang X, Ulrich P (1996) Directed approaches to reactive Maillard intermediates: Formation of a novel 3-alkyl-amino-2-hydroxy-4-hydroxymethyl-2-cyclopenten-1-one ("cypentodine"). Tetrahedron Lett 37: 4667-4670