Loss of body fat in lean parabiotic partners of ob/ob mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 272, Issue 6 41-6, 1997, Pages

  Harris, Ruth B S ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Leptin; Parabiosis

Indexed keywords

INSULIN; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY TEMPERATURE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GENE EXPRESSION; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; MOUSE; NONHUMAN; OBESITY; PARABIOSIS; PRIORITY JOURNAL; RECTUM TEMPERATURE;

EID: 0030850740     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.272.6.r1809     Document Type: Article

References (20)

1. Ahima, R. S., D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Mataros-Flier, and J. S. Flier. Role of leptin in the neuroendocrine response to fasting. Nature 382: 350-351, 1996.
2. Chehab, F. F., M. E. Lim, and R. Lu. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12: 318-320, 1996.
3. Chlouverakis, C. Insulin resistance of parabiotic obesehyperglycemic mice (obob). Harm. Metab. Res. 4: 143-148, 1972.
4. Coleman, D. L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9: 294-298, 1973.
5. Coleman, D. L., and K. Hummel. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 217: 1298-1304,1969.
6. Finerty, J. C., and T. C. Panos. Parabiosis intoxication. Proc. Soc. Exp. Biol. Med. 76: 833-835, 1951.
7. Frisch, R. Fatness, menarche, and female fertility. Perspect. Biol. Med. 28: 611-633, 1985.
8. Haessler, H. A., and J. D. Crawford. Alterations in the fatty acid composition of depot fat associated with obesity. Ann. NY Acad. Sci. 131: 476-484, 1965.
9. Hamilton, B. S., D. Paglia, A. Y. M. Kwan, and M. Deitel. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med. 1: 953-955, 1995.
10. Harris, R. B. S., and R. J. Martin. Specific depletion of body fat in parabiotic partners of tube-fed obese rats. Am. J. Physiol. 247 (Regulatory Integrative Comp. Physiol. 16): R380-R386, 1984.
11. Harris, R. B. S., T. G. Ramsay, S. R. Smith, and R. C. Bruch. Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. J. Clin. Invest. 97: 2020-2026, 1996.
12. Harris, R. B. S., J. Zhou, D. S. Weigle, and J. L. Kuijper. Recombinant leptin exchanges between parabiosed mice but does not reach equilibrium. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R1780-R1788, 1997.
13. Hausberger, F. X. Parabiosis and transplantation experiments in hereditary obese mice (Abstract). Anat. Rec. 130: 313, 1958.
14. Hervey, G. R. Effects of lesions in the hypothalamus in parabiotic rats. J. Physiol. (Lond.) 145: 336-352, 1959.
15. Levin, N., C. Nelson, A. Gurney, R. Vandelen, and F. DeSauvage. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc. Natl. Acad. Sci. USA 93: 1726-1730, 1996.
16. Lonnqvist, F., P. Arner, L. Nordfors, and M. Schalling. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat. Med. 1: 950-953, 1995.
17. Parameswaran, S. V., A. B. Steffens, G. R. Hervey, and L. de Ruiter. Involvement of a humoral factor in regulation of body weight in parabiotic rats. Am. J. Physiol. 232 (Regulatory Integrative Comp. Physiol. 1): R150-R157, 1977.
18. Pellymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
19. Saladin, R., P. De Vos, M. Guerre-Millo, A. Leturque, J. Girard, B. Staels, and J. Auwerx. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529, 1995.
20. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.