Evidence for Directed Metalation: A Structural Intermediate in the Formation of a Novel C-bound Adenine Complex of Ruthenium

Angewandte Chemie (International Edition in English)

Volumn 36, Issue 16, 1997, Pages 1762-1764

  Price, Clayton ^a   Elsegood, Mark R J ^a   Clegg, William ^a   Rees, Nicholas H ^a   Houlton, Andrew ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Adenine; Bioinorganic chemistry; N ligands; Nucleobases; Ruthenium

Indexed keywords

EID: 0030850532     PISSN: 05700833     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.199717621     Document Type: Article

References (22)

1. Metal Ions in Biological Systems, Vol. 32, (Eds.: A. Sigel, H. Sigel), Marcel Dekker, New York, 1996.
2. B. Lippert, Prog. Inorg. Chem. 1989, 37, 1-97.
3. S. E. Sherman, S. J. Lippard, Chem. Rev. 1987, 87, 1153-1181.
4. Nucleic Acids in Chemistry and Biology, (Eds.: G. M. Blackburn, M. J. Gait), IRL Press, Oxford, 1990.
5. C. Price, M. R. J. Elsegood, W. Clegg, A. Houlton, J. Chem. Soc. Chem. Commun. 1995, 2285-2286.
6. Metal complexes derived from nucleobase-ligand conjugates have been prepared by ourselves and other workers; however, in these cases metal - nucleo-base binding is precluded. See for example U. Koert, M. M. Harding, J.-M. Lehn, Nature 1990, 346, 339-341: J. L. Sessler, C. T Brown, R. Wang, Inorg. Chim. Acta 1996, 251, 135-140; E. C. Constable, R.-A. Fallahpour, J. Chem. Soc. Dalton Trans. 1996, 2389-2390; C. Price, M. Aslanglu, C. J. Isaac, M. R. J. Elsegood, W. Clegg, B. R. Horrocks, A. Houlton, ibid. 1996, 4115-4120.
7. Metal complexes derived from nucleobase-ligand conjugates have been prepared by ourselves and other workers; however, in these cases metal - nucleo-base binding is precluded. See for example U. Koert, M. M. Harding, J.-M. Lehn, Nature 1990, 346, 339-341: J. L. Sessler, C. T Brown, R. Wang, Inorg. Chim. Acta 1996, 251, 135-140; E. C. Constable, R.-A. Fallahpour, J. Chem. Soc. Dalton Trans. 1996, 2389-2390; C. Price, M. Aslanglu, C. J. Isaac, M. R. J. Elsegood, W. Clegg, B. R. Horrocks, A. Houlton, ibid. 1996, 4115-4120.
8. Metal complexes derived from nucleobase-ligand conjugates have been prepared by ourselves and other workers; however, in these cases metal - nucleo-base binding is precluded. See for example U. Koert, M. M. Harding, J.-M. Lehn, Nature 1990, 346, 339-341: J. L. Sessler, C. T Brown, R. Wang, Inorg. Chim. Acta 1996, 251, 135-140; E. C. Constable, R.-A. Fallahpour, J. Chem. Soc. Dalton Trans. 1996, 2389-2390; C. Price, M. Aslanglu, C. J. Isaac, M. R. J. Elsegood, W. Clegg, B. R. Horrocks, A. Houlton, ibid. 1996, 4115-4120.
9. Metal complexes derived from nucleobase-ligand conjugates have been prepared by ourselves and other workers; however, in these cases metal - nucleo-base binding is precluded. See for example U. Koert, M. M. Harding, J.-M. Lehn, Nature 1990, 346, 339-341: J. L. Sessler, C. T Brown, R. Wang, Inorg. Chim. Acta 1996, 251, 135-140; E. C. Constable, R.-A. Fallahpour, J. Chem. Soc. Dalton Trans. 1996, 2389-2390; C. Price, M. Aslanglu, C. J. Isaac, M. R. J. Elsegood, W. Clegg, B. R. Horrocks, A. Houlton, ibid. 1996, 4115-4120.
10. int = 0.0356) data, transmission: 0.815-0.962. The structure was solved by direct methods. wR = 0.0991, R = 0.0382 (3295 F values), 5 = 1.117 for 232 parameters. Coordinates of H atoms on N7, N10, and O2 were freely refined, all others were riding. Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC-100265. Copies of the data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK (fax: int. code +(1223)336-033; e-mail: deposit@chemcrys.cam.ac.uk).
11. W. S. Sheldrick, S. Heeb, Inorg. Chim. Acta 1990, 168, 93-100; P. M. Van Vliet, J. G. Haasnoot, J. Reedijk, Inorg. Chem. 1994, 33, 1934-1939.
12. W. S. Sheldrick, S. Heeb, Inorg. Chim. Acta 1990, 168, 93-100; P. M. Van Vliet, J. G. Haasnoot, J. Reedijk, Inorg. Chem. 1994, 33, 1934-1939.
13. W. S. Sheldrick, H. S. Hagen-Eckhard, S. Heeb. Inorg. Chim. Acta 1993, 206, 15-21.
14. R. Cini, A. Cinquantini, M. Sabat, L. G. Marzilli, Inorg. Chem. 1985, 24, 3903-3908; R. Cini, R. Bozzi, A. Karaulov, M. B. Hursthouse, A. M. Calafat, L. G. Marzilli, J. Chem. Soc., Chem. Commun. 1993, 899-901.
15. R. Cini, A. Cinquantini, M. Sabat, L. G. Marzilli, Inorg. Chem. 1985, 24, 3903-3908; R. Cini, R. Bozzi, A. Karaulov, M. B. Hursthouse, A. M. Calafat, L. G. Marzilli, J. Chem. Soc., Chem. Commun. 1993, 899-901.
16. H. J. Krentzien, M. J. Clarke, H. Taube, Bioinorg. Chem. 1975, 4, 143-151.
17. M. J. Clarke, H. Taube, J. Am. Chem. Soc. 1975, 97, 1397-1403.
18. R. J. Sundberg, R. F. Bryan, I. F. Taylor, Jr., H. Taube, J. Am. Chem. Soc. 1974, 96, 381-392.
19. H. Schöllhorn, U. Thewalt, B. Lippert, J. Chem. Soc. Chem. Commun. 1986, 258-260.
20. M. Hopp, A. Erxleben, I. Rombeck, B. Lippert, Inorg. Chem. 1996, 35, 397-403.
21. F. Zamora, M. Sabat, B. Lippert, Inorg. Chem. 1996, 35, 4858-4864.
22. E. Alessio, G. Balducci, M. Calligaris, G. Costa, W M. Attia, G. Mestroni, Inorg. Chem. 1991, 30, 609-618.