Degradation of suramin in aqueous solutions

International Journal of Pharmaceutics

Volumn 155, Issue 1, 1997, Pages 27-34

  Kettenes van Den Bosch, J J ^a   Hop, E ^a   Overbeek, W ^a   Underberg, W J M ^a   Beijnen, J H ^a   Bult, A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Degradation products; Stability; Suramin

Indexed keywords

SURAMIN; UREA DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; DRUG DEGRADATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0030849496     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00166-X     Document Type: Article

References (5)

1. Beijnen, J.H., van Gijn, R., de Clippeleir, J.J.M., Vlasveld, L.Th., Horenblas, S., Underberg, W.J.M., 1990a. Rapid determination of suramin in micro-volumes of plasma by using ion-pair high performance liquid chromatography. J. Drug Dev. 3 (1), 21-26.
2. Beijnen, J.H., van Gijn, R., Horenblas, S., Underberg, W.J.M., 1990b. Chemical stability of suramin in commonly used infusion fluids. DICP Ann. Pharmacother. 24, 1056-1058.
3. Hawking, F., 1978. Suramin: with special reference to onchocerciasis. Adv. Pharmacol. Chemother. 15, 289-322.
4. Mitsuya, H., Popovic, M., Yarchoan, R., Matshushita, S., Gallo, R.C., Broder, S., 1984. Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III. Science 226, 172-174.
5. Stein, C.A., LaRocca, R.V., Thomas, R., McAtee, N., Myers, C.E., 1989. Suramin: an anticancer drug with a unique mechanism of action. J. Clin. Oncol. 17, 499.