Targeted drug delivery to the skin and deeper tissues: Role of physiology, solute structure and disease

Clinical and Experimental Pharmacology and Physiology

Volumn 24, Issue 11, 1997, Pages 874-879

  Roberts, M S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Dermatology; Enhancers; Iontophoresis; Regional drug delivery; Skin absorption; Skin penetration; Stratum corneum; Structure penetration relationships; Topical therapy; Transdermal delivery

Indexed keywords

ARTICLE; DERMATOLOGY; DRUG DELIVERY SYSTEM; DRUG TARGETING; DRUG TRANSPORT; HUMAN; IONTOPHORESIS; NONHUMAN; PSORIASIS; SKIN ABSORPTION; SKIN BLOOD FLOW; SKIN DISEASE; SKIN PENETRATION; SKIN PERMEABILITY; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030848511     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1997.tb02708.x     Document Type: Article

References (23)

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3. Barry BW. Transdermal drug delivery. In: Johnson P, Lloyd-Jones JG (eds). Drug Delivery Systems. Ellis Horwood, Chichester. 1987; Ch. 12.
4. Asokan P, Das M, Bik DP et al. Comparative effects of topically applied nitrated arenes and their nonnitrated parent arenes on cutaneous and hepatic drug and carcinogen metabolism in neonatal rats. Toxicol. Appl. Pharmacol. 1986; 86: 33-43.
5. Scott RC, Walker M, Dugard PH. A comparison of the in vitro permeability properties of human and some laboratory animal skins. Int. J. Cosmet. Sci. 1986; 8: 189-94.
6. Walters KA, Roberts MS. Veterinary applications of skin penetration enhancers. In: Walters KA, Hadgraft J (eds). Skin Penetration Enhancement. Marcel Dekker, New York. 1993; Ch. 16.
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8. Roberts MS. Structure-permeability considerations in percutaneous absorption. In: Scott RC, Guy RH, Hadgraft J, Bodde HE (eds). Prediction of Percutaneous Penetration: Methods, Measurement and Modelling, vol. 2. IBC Technical Services Ltd, London. 1991; 210-28.
9. Friend DR, Heller J. Simple alkyl esters as skin penetration enhancers. In: Walters KA, Hadgraft J (eds). Skin Penetration Enhancement. Marcel Dekker, New York. 1993; Ch. 2.
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11. Rademacher J, Jentsch D, Scholl MA, Lustinetz T, Frolich JC. Diclofenac concentrations in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease. Br. J. Clin. Pharmacol. 1991; 31: 537-41.
12. Singh P, Roberts MS. Dermal and underlying tissue pharmacokinetics of salicylic acid after topical application. J. Pharmacokinet. Biopharm. 1993; 21: 337-73.
13. Roberts MS, Anderson RA, Swarbrick J. Permeability of human epidermis to phenolic compounds. J. Pharm. Pharmacol. 1977; 29: 677-83.
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15. Yoshida NH, Roberts MS. Prediction of cathodal iontophoretic transport of various anions across excised skin from different vehicles using conductivity measurements. J. Pharm. Pharmacol. 1995; 47: 883-90.
16. Davis AF, Hadgraft J. Supersaturated solutions as topical drug delivery systems. In: Walters KA, Hadgraft J (eds). Skin Penetration Enhancement. Marcel Dekker, New York. 1993; Ch. 11.
17. Scheuplein RJ, Blank IH. Permeability of the skin. Physiol. Rev. 1971; 51: 702-47.
18. Roberts MS, Favretto WA, Meyer A, Reckmann M, Wongseelashote T. Topical bioavailability of methyl salicylate. Aust. N.Z. J. Med. 1982; 12: 303-5.
19. Singh P, Roberts MS. Effects of vasoconstriction on dermal pharmacokinetics and local tissue distribution of compounds. J. Pharm. Sci. 1994; 83: 783-91.
20. Megwa SA, Benson HAE, Roberts MS. Percutaneous absorption of salicylates from some commercially available topical products containing methyl salicylate or salicylate salts in rats. J. Pharm. Pharmacol. 1995; 47: 891-6.
21. Hassan-Zadek D, Lai PM, Roberts MS. Comparison of AC, DC pulsed and DC constant current in iontophoretic transport of propranolol. Proc. Australas. Soc. Clin. Exp. Pharmacol. Toxicol. 1996; 3: 126.
22. Lai PM, Roberts MS. Iontophoretic drug delivery and toxicity assessment. Marcel Dekker, New York. 1997 (in press).
23. Walters KA, Hadgraft J. Pharmaceutical skin penetration enhancement. Marcel Dekker, New York. 1993.