p53 mutation and protein alteration in 50 gliomas. Retrospective study by DNA-sequencing techniques and immunohistochemistry

Histology and Histopathology

Volumn 12, Issue 3, 1997, Pages 611-616

  Gries, H ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Diagnosis; DNA sequencing; Glioma; Immunohistochemistry; P53

Indexed keywords

GENE PRODUCT; PROTEIN P53;

ARTICLE; ASTROCYTOMA; CLINICAL PROTOCOL; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NEUROECTODERM TUMOR; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR CLASSIFICATION; TUMOR SUPPRESSOR GENE; WORLD HEALTH ORGANIZATION;

CENTRAL NERVOUS SYSTEM NEOPLASMS; DNA; GENES, P53; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RETROSPECTIVE STUDIES; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030848309     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Bischoff J.R., Friedman P.N., Marshak D.R., Prives C. and Beach D. (1990). Human p53 is phosphorylated by p60-cdc2 and cyclin-B-cdc2. Proc. Natl. Acad. Sci. USA 87, 4766-4770.
2. Bögler O., Huang H.-J.S., Kleihues P. and Cavenee W.K. (1995). The p53 gene and its role in human brain tumors. Glia 15, 308-327.
3. Chozick B.S., Weiker M.E., Pezzullo J.C., Jackson C.L., Finkelstein S.D., Ambler M.W., Epstein M.H. and Finch P.W. (1994). Pattern of mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis. Cancer 73, 406-415.
4. Deimling A. von, Eibl R.H., Ohgaki K., Louis D.N., von Ammon K., Petersen I., Kleihues P., Chung R.Y., Wiestler O.D. and Seizinger B.R. (1992). p53 mutations correlate with 17p allelic loss in grade II and grade lit astrocytoma. Cancer Res. 52, 2897-2900.
5. Deimling A. von, von Ammon K., Schoenfeld D., Wiestler O.D., Seizinger B.R. and Louis D.N. (1993). Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol. 3, 19-26.