Intra-individual variation in serum AZT concentration is not related to intestinal absorption or small intestinal inflammatory changes in human immunodeficiency virus-infected subjects

Antiviral Chemistry and Chemotherapy

Volumn 8, Issue 4, 1997, Pages 327-332

  Sherwood, R A ^a   Marsden, J T ^a   Stein, C A ^b   Somasundaram, S ^a   Aitken, C ^b   Oxford, J S ^b   Menzies, I S ^a   Bjarnason, I ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

AZT therapy; AZT glucuronide; Cryptosporidial diarrhoea; Intestinal inflammation; Intestinal permeability; Xylose

Indexed keywords

3 METHYLGLUCOSE; DRUG METABOLITE; LACTULOSE; LEUKOCYTE IN 111; RHAMNOSE; XYLOSE; ZIDOVUDINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENTERITIS; GASTROINTESTINAL DISEASE; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTESTINE ABSORPTION; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; URINARY EXCRETION; VARIANCE;

EID: 0030847925     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029700800405     Document Type: Article

References (28)

1. Anonymous (1988) Leads from the MMWR. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Journal of the American Medical Association 258: 1143-1154.
2. Bjarnason I, Zanelli G, Smith T, Prouse P, Williams P, Smethurst P, Delacey G, Gumpel MJ & Levi AJ (1987) Non-steroidal anti-inflammatory drug induced intestinal inflammation in man. Gastroenterology 93: 480-489.
3. Bjarnason I, MacPherson A & Menzies IS (1994) Intestinal permeability: the basics. In Inflammatory Bowel Disease. Basic Research, Clinical Implications and Trends in Therapy. Edited by LR Sutherland, SM Collins, F Martin, RS McLeod, SR Targan, JLK Wallace & CN Williams. Dordrecht: Kluwer Academic Publishers, pp. 53-70.
4. Bjarnason I, Macpherson A & Hollander D (1995) Intestinal permeability: an overview. Gastroenterology 108: 1566-1581.
5. Cload PA (1988) A review of the pharmacokinetics of zidovudine in man. Journal of Infection 18: (Supplementum) 15-21.
6. Concorde Co-ordinating Committee (1994) Concorde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom free HIV infection. Lancet 343: 871-881.
7. Connolly MG, Forbes A, Gleeson JA & Gazzard BG (1989) Investigation of upper gastrointestinal symptoms in patients with AIDS. AIDS 3: 453-456.
8. Cooper DA, Gatell JM, Kroon S, Clumeck N, Millard J, Goebel F-D, Bruun JN, Stingl G, Melville RL, Gonzalez-Lahoz J, Stevens JW & Fiddian AP (1993) Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter. New England Journal of Medicine 329: 297-303.
9. Gazzard BG (1990) Practical advice for the gastroenterologist dealing with symptomatic HIV disease. Gut 31: 733-735.
10. Gillin JS, Shike M, Alcock N, Urmacher C, Krown S, Kurtz RC, Lightdale CJ & Winawer SJ (1985) Malabsorption and mucosal abnormalities of the small intestine in the acquired immunodeficiency syndrome. Annals of Internal Medicine 102: 619-622.
11. Isolauri E, Juntunen M, Wirens S, Vuirien P & Koivula T (1989) Intestinal permeability changes in acute gastroenteritis: effects of clinical factors and nutritional management. Journal of Pediatric Gastroenterology and Nutrition 8: 466-473.
12. Kapembwa MS, Fleming SC, Griffin GE, Caun K, Pinching AJ &. Harris JRW (1990) Fat malabsorption and exocrine pancreatic function in human immunodeficiency infection. Quarterly Journal of Medicine 74: 49-56.
13. Kapembwa MS, Fleming SC, Sewankambo N, Serwadda D, Lucas S, Moody A & Griffin GE (1991) Altered small intestinal permeability associated with diarrhoea in human immunodeficiency virus infected Caucasian and African subjects. Clinical Science 81: 327-334.
14. Keating J, Bjarnason I, Somasundaram S, McPherson A, Francis N, Price AB, Sharpstone D, Smithson J, Menzies IS & Gazzard BG (1995) Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea. Gut 37: 623-629.
15. Kotler DP, Francisco A, Clayton F, Scholes JV & Orenstein JM (1990) Small intestinal injury and parasitic disease in AIDS. Annals of Internal Medicine 113: 444-449.
16. Laskin OL, de Miranda P & Blum MR (1989) AZT steady-state pharmacokinetics in patients with AIDS and AIDS-related complex. Journal of Infectious Diseases 159: 745-747.
17. Lawson GR, Nelson R, Laker MF, Ghakei MA, Bloom SR & Aynsley GA (1992) Gut regulatory peptides and intestinal permeability in acute infantile gastroenteritis. Archives of Diseases in Childhood 67: 272-276.
18. Lim SG, Menzies IS, Lee CA, Johnson MA &. Pounder RE (1993) Intestinal permeability and function in patients infected with human immunodeficiency virus. Scandinavian Journal of Gastroenterology 28: 573-580.
19. McLeod GX & Hammer SM (1992) Zidovudine: five years later. Annals of Internal Medicine 117: 487-501.
20. Miller ARO, Griffin GE, Batman P, Farquar C, Forster SM, Pinching AJ & Harris JRW (1988) Jejunal mucosal architecture and fat malabsorption in male homosexuals infected with human immunodeficiency virus. Quarterly Journal of Medicine 69: 1009-1019.
21. Miller TL, Orav EJ, Martin SR, Cooper ER, McIntosh K & Winter HS (1991) Malnutrition and carbohydrate malabsorption in children with vertically transmitted HIV1 infection. Gastroenterology 100: 1296-1302.
22. Morse GD, Olson J, Portmore A, Taylor C, Plank C & Reichman RC (1989) Pharmacokinetics of orally administered zidovudine among patients with hemophilia and asymptomatic human immunodeficiency virus (HIV) infection. Antiviral Research 11: 57-66.
23. Ott M, Lembecke B, Staszewski S, Helm EB & Caspary WF (1991) Intestinal permeability in patients with acquired immunodeficiency syndrome (AIDS). Klinische Wochenschrift 69: 715-721.
24. Singlas E, Pioger JC, Taburet AM, Colin JN & Fillastre JP (1994) Zidovudine disposition in patients with severe renal impairment: influence of hemodialysis. Clinical Pharmacology and Therapeutics 46: 190-197.
25. Stretcher BN (1991) State-of-the-art of zidovudine monitoring. Journal of Clinical Laboratory Analysis 5: 60-68.
26. Teahon K, Smethurst P, Levi AJ, Menzies IS & Bjarnason I (1992) Intestinal permeability in patients with Crohn's disease and their first degree relatives. Gut 33: 320-323.
27. Travis S & Menzies I (1992) Intestinal permeability: functional assessment and significance. Clinical Science 82: 471-488.
28. Ullrich R, Zeitz M, Heise W, L'age M, Hoffken G & Riecken EO (1989) Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy. Annals of Internal Medicine 111: 15-21.