Extracellular Mg++ manipulation prevents the proarrhythmic activity of cromakalim in ischemic/reperfused diabetic hearts

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 309-317

  Tosaki, Arpad ^a   Das, Dipak K ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CROMAKALIM; GLIBENCLAMIDE; MAGNESIUM ION; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION; SODIUM ION;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALS; ARRHYTHMIA; BENZOPYRANS; CALCIUM; CROMAKALIM; DIABETES MELLITUS, EXPERIMENTAL; HEART; MAGNESIUM; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; POTASSIUM CHANNELS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; STREPTOZOCIN;

EID: 0030847488     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. AFZAL, N., PIERCE, G. N., ELIMBAN, V., BEAMISH, R. E. AND DHALLA, N. S.: Influence of verapamil on some subcellular defects in the diabetic cardiomyopathy. Am. J. Physiol. 256: E453-E458, 1989.
2. AHNFELT-RONNE, I.: Pinacidil: History, basic pharmacology, and therapeutic implications. J. Cardiovasc. Pharmacol. 12(Suppl. 2): S1-S4, 1988.
3. ALTO, L. E. AND DHALLA, N. S.: Myocardial cation contents during induction of calcium paradox. Am. J. Physiol. 237: 713-719, 1979.
4. ALTURA, B. M. AND ALTURA, B. T.: Magnesium, electrolyte transport and coronary vascular tone. Drugs 28(Suppl. 1): 120-142, 1984.
5. BAKTH, S., ARENA, J., LEE, W., TORRES, R., HAIDER, B., PATEL, B. C., LYONS, M. M. AND REGAN, T.J.: Arrhythmia suceptibility and myocardial composition in diabetes: Influence of physical conditioning. J. Clin. Invest. 77: 382-395, 1986.
6. BEATCH, G. N. AND MCNEILL, J. H.: Ventricular arrhythmias following coronary artery occlusion in the streptozotocin diabetic rat. Can. J. Physiol. Pharmacol. 66: 312-317, 1988.
7. BILLMAN, G., AVENDANO, C. E., HALLIWILL, J. R. AND BURROUGHS, J. M.: The effects of the ATP-dependent potassium channel antagonists, glyburide, on coronary blood flow and susceptibility to ventricular fibrillation in unanesthetized dogs. J. Cardiovasc. Pharmacol. 21: 197-204, 1993.
8. BOISSEL, J. P., CASTAIGNE, A., MERCIER, C., LION, L. AND LEIZOROVICZ, A.: Ventricular fibrillation following administration of thrombolytic treatment: the EMIP experience. Eur. Heart J. 17: 213-221, 1996.
9. 31P-NMR. Am. J. Physiol. 256: H195-H204, 1989.
10. CORONEL, R., WILMS-SCHOPMAN, F. J. G., FIOLET, J. W. T., OPTHOF, T. AND JANSE, M. J.: The relation between extracellular potassium concentration and pH in the border zone during regional ischemia in isolated porcine hearts. J. Mol. Cell. Cardiol. 27: 2069-2073, 1995.
11. CORONEL, R., WILMS-SCHOPMAN, F. J. G., OPHTHOF, T., CINCA, J., FIOLET, J. W. T. AND JANSE, M. J.: Reperfusion arrhythmias in isolated perfused pig hearts: inhomogeneities in extracellular potassium, ST and TQ potentials, and transmembrane action potentials. Circ. Res. 71: 1131-1142, 1992.
12. CURTIS, M. J. AND HEARSE, D. J.: Reperfusion-induced arrhythmias are critically dependent upon occluded zone size: Relevance to the mechanism of arrhythmogenesis. J. Mol. Cell. Cardiol. 21: 625-637, 1989.
13. CURTIS, M. J., MACLEOD, B. A. AND WALKER, M. J. A.: Models for the studies of arrhythmias in myocardial ischemia and infarction: The use of the rat. J. Mol. Cell. Cardiol. 19: 399-419, 1987.
14. DONALDSON, S. K. B. AND KERRICK, W. G. L.: Characterization of the effects of Mg on Ca-and SR-activated tensiongeneration of skinned cardiac fibers. J. Gen. Physiol. 71: 645-655, 1978.
15. Fabiato, A. and Fabiato, F.: Effects of magnesium on contractile activation of skinned cardiac cells. J. Physiol. (Lond.) 249: 497-517, 1975.
16. ATP channel modulation in working rat hearts with coronary occlusion: Effects of cromakalim, cicletainine, and glibenclamide. Cardiovasc. Res. 30: 781-787, 1995.
17. FEUVRAY, D., IDELL-WENGER, J. A. AND NEELY, J. R.: Effects of ischemia on rat myocardial function and metabolism in diabetes. Circ. Res. 44: 322-329, 1979.
18. + channels in mammalian ventricular myocytes. Am. J. Physiol. 257: H1551-H1559, 1989.
19. FISET, C., KARGACIN, M. E., KONDO, C. S., LESTER, W. M. AND DUFF, H. J.: Hypomagnesemia: Characterization of a model of sudden cardiac death. J. Am. Coll. Cardiol. 27: 1771-1776, 1996.
20. Fox, J. S., WHITEHEAD, E. M. AND SHANKS, R. G.: Cardiovascular effects of cromakalim (BRL 34915) in healthy volunteers. Br. J. Clin. Pharmacol. 32: 45-49, 1991.
21. FRIEDRICHS, G. S., CHI, L., BLACK, S. C., MANLEY, P. J., OH, J. Y. AND LUCCHESI, B. R.: Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels. J. Pharmacol. Exp. Ther. 266: 1348-1354, 1993.
22. GOLDBERG, M. R., SUSHAK, C. S., ROCKHOLD, F. W. AND THOMPSON, W. L.: Vasodilator monotherapy in the treatment of hypertension: Comparative efficacy and safety of pinacidil, a potassium channel opener, and prazosin. Clin. Pharmacol. Ther. 44: 78-92, 1988.
23. GOTZSCHE, O.: The adrenergic beta-receptor adenylate cyclase system in heart and lymphocytes from streptozotocin-diabetic rats: In vivo and in vitro evidence for a desensitized myocardial beta-receptor. Diabetes 32: 1110-1116, 1983.
24. GROSS, G. J. AND AUCHAMPACH, J. A.: Role of ATP dependent potassium channels in myocardial ischemia. Cardiovasc. Res. 26: 1011-1016, 1992.
25. ATP opner cromakalim is not correlated with ischemic myocardial action potential duration. J. Cardiovasc. Pharm. 26: 145-152, 1995.
26. GROVER, G. J., MCCULLOUGH, J. R., HENRY, D. E., CONDER, M. L. AND SLEPH, P. G.: Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with potassium channel blocker glyburide. J. Pharmacol. Exp. Ther. 251: 98-104, 1990.
27. HERZOG, W. R., ATAR, D., MAK, I. T., ALYONO, D., MACCORD, C. AND WEGLICKI, W. B.: Magnesium deficiency prolonges myocardial stunning in an open-chest swine model. Int. J. Cardiol. 47: 105-115, 1994.
28. JACKSON, C. V., MCGRATH, G. M., TAHILIANI, A. G., VADLAMUDI, R. V. S. V. AND MCNEILL, J. H.: A functional and ultrastructural analysis of experimental diabetic rat myocardium: Manifestation of a cardiomyopathy. Diabetes 34: 876-883, 1985.
29. JOHNSTON, K. M., MACLEOD, B. A. AND WALKER, M. J. A.: Responses to ligation of a coronary artery in conscious rats and the actions of antiarrhythmias. Can. J. Physiol. Pharmacol. 61: 1340-1353, 1983.
30. + exchange during ischemia and reperfusion of normal and diabetic rat hearts. Cardiovasc. Res. 24: 873-878, 1990.
31. KHANDOUDI, N., BERNARD, M., COZZONE, P. AND FEUVRAY, D.: Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts. Diabetes 44: 196-202, 1995.
32. KUSAMA, Y., HEARSE, D. J. AND AVKIRAN, M.: Diabetes and susceptibility to reperfusion-induced ventricular arrhythmias. J. Mol. Cell. Cardiol. 24: 411-421, 1992.
33. LATHROP, D. A., NANASI, P. P. AND VARRO A.: In vitro cardiac models of dog Purkinje fiber triggered and spontaneous electrical activity: Effects of nicorandil. Br. J. Pharmacol. 99: 119-123, 1990.
34. LIU, Y., THORNTON, J. D., COHEN, M. V., DOWNEY, J. M. AND SCHAFFER, S. W.: Streptozotocin-induced non-insulin-dependent diabetes protects the heart from infarction. Circulation 88: 1273-1278, 1993.
35. LOPASCHUK, G. D., TAHILIANI, A. G., VADLAMUDI, R. V. S. V., KATZ, S. AND MCNEIL, J. H.: Cardiac sarcoplasmic reticulum function in insulin-carnitine-treated diabetic rats. Am. J. Physiol. 245: H969-H976, 1983.
36. 2+ transport in streptozotocin-induced diabetic cardiomyophaty in rats. Am. J. Physiol. 253: E202-E207, 1987.
37. MCWILLIAMS, J. A.: Fibrillar contraction of the heart. J. Physiol. (Lond.) 8:296-310, 1887.
38. MISIER, A. R. R., OPTHOF, T., HEMEL, N. M., VERMEULEN, J. T., DE BARKER, J. M. T., DEFAUW, J. J. A. M., VAN CAPELLE, F. J. L. AND JANSE, M. J.: Dispersion of 'refractoriness' in noninfarcted myocardium of patients with ventricular tachycardia or ventricular fibrillation after myocardial infarction. Circulation 91: 2566-2572, 1995.
39. MIZUMURA, T., NITHIPATIKAM, K. AND GROSS, G. J.: Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. Circulation 92: 1236-1245, 1995.
40. NORTON, G. R., CANDY, G. AND WOODIWISS, A. J.: Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats. Circulation 93: 1905-1912, 1996.
41. + exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. Am. J. Physiol. 258: H255-H261, 1990.
42. POGWIZD, S. M. AND CORR, P. B.: Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: Results using three-dimensional mapping. Circ. Res. 61: 352-371, 1987.
43. PRIDJIAN, A. K., LEVITSKY, S., KRUKENKAMP, I., SILVERMAN, N. A. AND FEINBERG, H.: Developmental changes in reperfusion injury: A comparison of intracellular cation accumulation in the newborn, neonatal, and adult heart. J. Thorac. Cardiovasc. Surg. 93: 428-433, 1987.
44. 2+ transport in the heart. Nature (Lond.) 346: 841-844, 1990.
45. SANGUINETTI, M. C., SCOTT, A. L., ZINGARO, G. J. AND SIEGL, P. K. S.: BRL 34915 (cromakalim) activates ATP-sensitive potassium current in cardiac muscle. Proc. Natl. Acad. Sci. U.S.A. 85: 8360-8364, 1988.
46. SAUVIAT, M. P. AND FEUVRAY, D.: Electrophysiological analysis of the sensitivity to calcium in ventricular muscle from alloxan diabetic rats. Basic Res. Cardio. 81: 489-496, 1986.
47. SCHAFFER, S. W., WARNER, B. A. AND WILSON, G. L.: Effects of chronic glipizide treatment on the NIDD heart. Hormone Metabol. Res. 25: 348-352, 1993.
48. SCHNEIDER, A. J., MURRAY, W. B., MENTZER, S. C., MIRANDA, F., VADUVA, S.: "Helper": A critical events prompter for unexpected emergenices. J. Clin. Monitor. 11: 358-364, 1995.
49. SOLOMON, S. D., RIDKER, P. M. AND ANTMAN, E. M.: Ventricular arrhythmias in trials of thrombolytic therapy for acute myocardial infarction: A metaanalysis. Circulation 88: 2575-2581, 1993.
50. + current activated by pinacidil. Circ. Res. 68: 1127-1137, 1991.
51. STONE, P. H., MULLER, J. E., HARTWELL, T., YORK, B. J., RUTHERFORD, J. D., PARKER, C. B., TURI, Z. G., STRAUSS, H. W., WILLERSON, J. T., ROBERSTON, T., BRAUNWALD, E. AND JAFFE, A. S.: The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. J. Am. Coll. Cardiol. 14: 49-57, 1989.
52. 2+) by free radical scavengers in the rat retina. Ophthalmic. Res. 25: 1-9, 1993.
53. TOSAKI, A., ENGELMAN, D. T., ENGELMAN, R. M. AND DAS, D. K.: Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/ reperfused hearts. J. Pharmacol. Exp. Ther. 275: 1115-1123, 1995.
54. TOSAKI, A., ENGELMAN, D. T., ENGELMAN, R. M. AND DAS, D. K.: The evolution of diabetic response to ischemia/reperfusion and preconditioning in isolated working rat hearts. Cardiovasc. Res. 31: 526-536, 1996.
55. TOSAKI, A. AND HELLEGOUARCH, A.: Adenosine triphosphate-sensitive potassium channel blocker ameliorates, but the opener aggravates ischemia/ reperfusion-induced injury: Heart function studies in nonfibrillating isolated hearts. J. Am. Coll. Cardiol. 23: 487-496, 1994.
56. TOSAKI, A., KOLTAI, M. AND BRAQUET, P.: Effect of low extracellular sodium concentration on reperfusion-induced arrhythmias: Changes in the myocardial sodium, potassium and calcium contents in isolated guinea-pig hearts. Cardiovasc. Res. 23: 993-1000, 1989.
57. TOSAKI, A., KOLTAI, M., WILLOUGHBY, D. A. AND BRAQUET, P.: Effect of cicletainine on reperfusion-induced arrhythmias and ion shifts in isolated rat hearts. J. Cardiovasc. Pharmacol. 15: 218-216, 1990.
58. TOSAKI, A., SZERDAHELYI, P., ENGELMAN, R. M. AND DAS, D. K.: Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused hearts? J. Pharmacol. Exp. Ther. 267: 1355-1362, 1993.
59. + loss and cardiac function in ischemic and reperfused mammalian ventricle. Circ. Res. 71: 1324-1333, 1992.
60. WEEKE, J. AND ORSKOV, H.: Ultrasensitive radioimmunoassay for direct determination of free triiodothyronine concentration in serum. Scand. J. Clin. Lab. Invest. 35: 237-244, 1975.
61. WILDE, A. A. M.: ATP-sensitive potassium channels, transmural ischemia and the ECG implications for the non-insulin dependent diabetic patient? Cardiovasc. Res. 31: 688-690, 1996.
62. i responses to isoproterenol and cAMP in isolated cardiomyocytes from experimental diabetic rats. Am. J. Physiol. 266: H2334-H2342, 1994.