Social interaction: Responses to chlordiazepoxide and the loss of isolation-reared effects with paired-housing

Psychopharmacology

Volumn 133, Issue 2, 1997, Pages 127-132

  Vale, A L ^a   Montgomery, A M J ^a,b  

^a LONDON METROPOLITAN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

Chlordiazepoxide; Group reared; Isolated; Loss of isolation effects; Pair housed former isolates; Social interaction

Indexed keywords

CHLORDIAZEPOXIDE;

AGGRESSION; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; SOCIAL INTERACTION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; CHLORDIAZEPOXIDE; MALE; MOTOR ACTIVITY; RATS; SOCIAL BEHAVIOR; SOCIAL ISOLATION;

EID: 0030846779     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050382     Document Type: Article

References (25)

1. Berlyne DE (1960) Conflict, arousal and curiosity. McGraw Hill, New York, pp 31-40
2. Bickerdike MJ, Wright IK, Marsden CA (1993) Social isolation attenuates rat forebrain 5-HT release induced by KCI stimulation and exposure to a novel environment. Behav Pharmacol 4:231-236
3. Einon DF, Morgan MJ (1977) A critical period for social isolation in the rat. Dev Psychobiol 10:123-132
4. Einon DF, Tye NC (1975) Chlordiazepoxide and isolation-induced timidity in rats . Psychopharmacologia 44:85-88
5. File SF (1978) Exploration, distraction and habituation in rats reared in isolation. Dev Psychobiol 11:73-81
6. 2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology 123:346-352
7. Fulford AJ, Butler S, Heal DJ, Kendall DA, Marsden CA (1994) Evidence for altered alpha 2-adrenoceptor function following isolation-rearing in the rat. Psychopharmacology 116:183-190
8. Gardner CR, Guy AP (1984) A social interaction model of anxiety sensitive to acutely administered benzodiazepines. Drug Devel Res 4:207-216
9. Garzon J, Del Rio J (1981) Hyperactivity induced in rats by long-term isolation: further studies on a new animal model for the detection of antidepressants. Eur J Pharmacol 74:287-294
10. Gentsch C, Lichsteiner M, Frischknecht HR, Feer H, Siegfried B (1988) Isolation-induced locomotor hyper-activity and hypo-analgesia in rats are prevented by handling and reversed by resocialisation. Physiol Behav: 43:13-16
11. Jones GH, Marsden CA, Robbins TW (1990) Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens. Psychopharmacology 102:364-372
12. Jones GH, Hernandez TD, Kendall DA, Marsden CA, Robbins TW (1992) Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and post-mortem and invivo neurochemistry. Pharmacol Biochem Behav 43:17-35
13. Kraemer GW, Ebert MH, Lake CR, McKinney WT (1984) Hypersensitivity to d-amphetamine several years after early social deprivation in rhesus monkeys. Psychopharmacology 82: 266-271
14. Morgan MJ (1973) Effects of post-weaning environment on learning in the rat. Anim Behav 21:429-442
15. Morinan A, Parker V (1985) Are socially-isolated rats anxious? Br J Pharmacol 86:460P
16. Morley BL, Worsham E (1978) The effects of prolonged handling, scopolamine and physostigmine on the activity of isolated and socially reared rats. Physiol Psychol 6:83-88
17. Phillips GD, Howes SR, Whitelaw RB, Wilkinson LS, Robbins TW, Everitt BJ (1994) Isolation-rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine. Psychopharmacology 115:407-418
18. Robbins TW, Jones GH, Wilkinson LS (1996) Behavioural and neurochemical effects of early social deprivation in the rat. J Psychopharmacol 10:39-47
19. Sahakian BJ, Robbins TW, Iversen SD (1977) The effects of isolation rearing on exploration in the rat. Anim Learn Behav 5: 193-198
20. Treit D, Menard J, Royan C (1993) Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 44:463-469
21. Weinstock M, Speiser Z (1973) The effect of d-propranolol and practolol on the hyperactivity induced in rats by prolonged isolation. Psychopharmacologia 30:241-250
22. Wongwitdecha N, Marsden CA (1995) Isolation rearing reduces the anxiolytic effects of diazepam in the rat: social interaction test. Behav Pharmacol 6 [Suppl 9]:47-48
23. Wongwitdecha N, Marsden CA (1996) Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test. Behav Brain Res 75:27-32
24. Wood WE, Greenough WT (1974) Effect of grouping and crowding on learning in isolation-reared adult rats.Bull Psychonom Sci 3:65-67
25. Wright IA, Upton N, Marsden CA (1991) Resocialisation of isolation-reared rats does not alter their anxiogenic profile on the elevated X-maze model of anxiety. Physiol Behav 50: 1129-1132